alpha-Methyldopa sesquihydrate
- CAS No.
- 41372-08-1
- Chemical Name:
- alpha-Methyldopa sesquihydrate
- Synonyms
- (S)-2-AMINO-3-(3,4-DIHYDROXYPHENYL)-2-METHYLPROPIONIC ACID SESQUIHYDRATE;C07194;hyperpax;IDI1_000142;Prestwick2_;KBio2_001417;KBio2_003985;KBio2_006553;KBio3_001521;SPBio_001056
- CBNumber:
- CB7135325
- Molecular Formula:
- C10H15NO5
- Molecular Weight:
- 229.23
- MDL Number:
- MFCD30179484
- MOL File:
- 41372-08-1.mol
- MSDS File:
- SDS
| Melting point | >300 °C(lit.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Slightly soluble in water, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute mineral acids. |
| form | Solid |
| color | White to Off-White |
| optical activity | [α]25/D 13°, c = 1 in H2O |
| Water Solubility | 0.1-1 g/100 mL at 23 ºC |
| Sensitive | Air & Light Sensitive |
| Merck | 13,6080 |
| BRN | 2417244 |
| Stability | Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere. |
| CAS DataBase Reference | 41372-08-1(CAS DataBase Reference) |
| FDA UNII | 56LH93261Y |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Risk Statements | 20/21-36/37/38-42/43-65 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YP2860000 | |||||||||
| F | 10-23 | |||||||||
| HS Code | 2922504500 | |||||||||
| NFPA 704 |
|
alpha-Methyldopa sesquihydrate price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2672 | Methyldopa PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial | 41372-08-1 | 1G | $334 | 2024-03-01 | Buy |
| Sigma-Aldrich | 857416 | (?)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate 99% | 41372-08-1 | 5g | $77.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1426002 | Methyldopa United States Pharmacopeia (USP) Reference Standard | 41372-08-1 | 500mg | $802 | 2024-03-01 | Buy |
| Alfa Aesar | H56704 | (-)-3,4-Dihydroxy-alpha-methyl-L-phenylalanine sesquihydrate, 99% | 41372-08-1 | 1g | $14.65 | 2024-03-01 | Buy |
| Alfa Aesar | H56704 | (-)-3,4-Dihydroxy-alpha-methyl-L-phenylalanine sesquihydrate, 99% | 41372-08-1 | 5g | $49.65 | 2024-03-01 | Buy |
alpha-Methyldopa sesquihydrate Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Potent inhibitor of invertase and glucosidase inhibitor with a different specificity of action to DNJ and castanospermine. Inhibits glucosidase I.
Uses
Antihypertensive agent.
reaction suitability
reaction type: solution phase peptide synthesis
Biological Activity
l-(-)-α-methyldopa (hydrate) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.
Purification Methods
Recrystallise methyldopa from H2O. [Reinhold et al. J Org Chem 33 1209 1968.] The L-isomer forms a sesquihydrate from H2O m 302-304o (dec), and the anhydrous crystals are hygroscopic,[] 23D -4.0o (c 1, 0.1N HCl), []546 +154.5o (c 5, CuSO4 solution). It has max at 281nm ( 2780). Its solubility in H2O at 25o is ~10mg/mL and the pH of an aqueous solution is ~5.0. It is insoluble in most organic solvents. [Stein et al. J Am Chem Soc 77 700 1955, Beilstein 4 IV 2505.]
alpha-Methyldopa sesquihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| APOLLO HEALTHCARE RESOURCES | +6596580999 | sales@apollo-healthcare.com.sg | Singapore | 399 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18137 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Casorganics US Corp | +17326109938 | sales@casorganics.com | CHINA | 174 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531153977 | allison@yan-xi.com | China | 5854 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
View Lastest Price from alpha-Methyldopa sesquihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-25 | L-Methyldopa
41372-08-1
|
US $0.00-0.00 / Kg/Drum | 1KG | 98%-102%;USP | 100KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-04-15 | alpha-Methyldopa sesquihydrate
41372-08-1
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-03-21 | alpha-Methyldopa sesquihydrate
41372-08-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd |
-
- L-Methyldopa
41372-08-1
- US $0.00-0.00 / Kg/Drum
- 98%-102%;USP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- alpha-Methyldopa sesquihydrate
41372-08-1
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- alpha-Methyldopa sesquihydrate
41372-08-1
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd