bottromycin A(2)
- CAS No.
- 15005-62-6
- Chemical Name:
- bottromycin A(2)
- Synonyms
- bottromycin A(2);b-Alanine, N-[(2S)-2-[[glycyl-(3R)-3-methyl-Lprolyl-L-valyl]amino]-1-imino-3,3-dimethylbutyl]-3-methyl-L-valyl-(bS)-b-methyl-L-phenylalanyl-3-(2-thiazolyl)-, methyl ester, cyclic (1')-imine,(3R)-;β-Alanine, N-[(2S)-2-[[glycyl-(3R)-3-methyl-L-prolyl-L-valyl]amino]-1-imino-3,3-dimethylbutyl]-3-methyl-L-valyl-(βS)-β-methyl-L-phenylalanyl-3-(2-thiazolyl)-, methyl ester, cyclic (1→1')-imine, (3R)-
- CBNumber:
- CB71399096
- Molecular Formula:
- C42H62N8O7S
- Molecular Weight:
- 823.07
- MDL Number:
- MFCD34166124
- MOL File:
- 15005-62-6.mol
bottromycin A(2) Chemical Properties,Uses,Production
Biological Activity
Bottromycin A2 is an antibiotic originally isolated from Streptomyces.1 It blocks the binding of aminoacyl-tRNA to the A site of the 50S ribosome, inhibiting protein synthesis.2 Bottromycin A2 is active against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci with MIC values of 1 and 0.5 μg/ml, respectively.
References
1.Nakamura, S., Yajima, T., Lin, Y., et al.Isolation and characterization of bottromycins A2, B2, C2J. Antibiot. (Tokyo)20(1)1-5(1967) 2.Gouda, H., Kobayashi, Y., Yamada, T., et al.Three-dimensional solution structure of bottromycin A2: A potent antibiotic active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant EnterococciChem. Pharm. Bull. (Tokyo)60(2)169-171(2012)
bottromycin A(2) Preparation Products And Raw materials
Raw materials
Preparation Products
bottromycin A(2) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
Nanjing Peptide Biotech Ltd. | 025-025-58361106-805-805 13082558573 | liugang@njpeptide.com | China | 9978 | 55 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |
Supplier | Advantage |
---|---|
BOC Sciences | 58 |
Nanjing Peptide Biotech Ltd. | 55 |
Changzhou Furuisi Biotechnology Co., Ltd | 58 |
ChemeGen 中国 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
TargetMol Chemicals Inc. | 58 |