2-Amino-5-bromobenzoic acid
- CAS No.
- 5794-88-7
- Chemical Name:
- 2-Amino-5-bromobenzoic acid
- Synonyms
- 5-BROMOANTHRANILIC ACID;5-BROMO-2-AMINOBENZOIC ACID;BUTTPARK 89\07-49;RARECHEM AL BO 1183;5-bromo-anthranilicaci;2-Amino-5-bromobenzoic;5-Bromoantharanilic Acid;2-amino-5-bromo-benzoicaci;Anthranilic acid, 5-bromo-;2-AMINO-5-BROMOBENZOIC ACID
- CBNumber:
- CB7154465
- Molecular Formula:
- C7H6BrNO2
- Molecular Weight:
- 216.03
- MDL Number:
- MFCD00007823
- MOL File:
- 5794-88-7.mol
- MSDS File:
- SDS
Melting point | 213-215 °C (lit.) |
---|---|
Boiling point | 265.51°C (rough estimate) |
Density | 1.6841 (rough estimate) |
refractive index | 1.6120 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | Soluble in methanol and dimethyl sulfoxide. |
pka | 4.55±0.10(Predicted) |
form | Powder |
color | Beige |
Sensitive | Light Sensitive |
Merck | 14,1405 |
BRN | 639028 |
InChI | InChI=1S/C7H6BrNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11) |
InChIKey | CUKXRHLWPSBCTI-UHFFFAOYSA-N |
SMILES | C(O)(=O)C1=CC(Br)=CC=C1N |
CAS DataBase Reference | 5794-88-7(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | Q30190723F |
NIST Chemistry Reference | 2-Amino-5-bromobenzoic acid(5794-88-7) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H301-H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P270-P301+P310-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22-36/37 | |||||||||
Safety Statements | 26-38-36/37 | |||||||||
RIDADR | UN 2811 6.1/PG 3 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | CB2557670 | |||||||||
Hazard Note | Harmful | |||||||||
PackingGroup | 6.1/PG 3 | |||||||||
HS Code | 29224999 | |||||||||
NFPA 704 |
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2-Amino-5-bromobenzoic acid price More Price(47)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 260118 | 2-Amino-5-bromobenzoic acid 97% | 5794-88-7 | 5g | $58.4 | 2024-03-01 | Buy |
Sigma-Aldrich | 260118 | 2-Amino-5-bromobenzoic acid 97% | 5794-88-7 | 25g | $60 | 2024-03-01 | Buy |
TCI Chemical | A1254 | 5-Bromoanthranilic Acid >98.0%(HPLC)(T) | 5794-88-7 | 5g | $28 | 2024-03-01 | Buy |
TCI Chemical | A1254 | 5-Bromoanthranilic Acid >98.0%(HPLC)(T) | 5794-88-7 | 25g | $84 | 2024-03-01 | Buy |
Alfa Aesar | A11915 | 2-Amino-5-bromobenzoic acid, 98% | 5794-88-7 | 5g | $48.65 | 2024-03-01 | Buy |
2-Amino-5-bromobenzoic acid Chemical Properties,Uses,Production
Synthesis
A solution of bromine (7.2 g, 2 mL, 40 mmol) in 47 mL glacial acetic acid was added dropwise to sodium 2-aminobenzoate (6.4 g, 40 mmol) in 32 mL of glacial acetic acid at 15 °С and the mixture was stirred for 1 h at the same temperature. The product was filtered off, washed with benzene and dried in the dark. The bromobenzoic acids containing mixture (0.5 g) was added to 10 mL of boiling water followed by the addition of 1.3 mL of concentrated hydrochloric acid and hot filtration under vacuum. The insoluble material contained 2-amino-3,5-dibromobenzoic acid, whereas 2- amino-5-bromobenzoic acid precipitated upon cooling of the filtrate. IR (suspension in nujol, cm−1 ): 3497, 3383, 1675, 1616, 1587, 1548, 1423, 1377, 1316, 1292, 1239, 1160, 1127, 812, 748, 691.
Chemical Properties
slight yellow to white powder
Physical properties
2-Amino-5-bromobenzoic acid has 17 atoms, meaning 45 vibrational modes in three main parts: Carboxyl group, amine group, and benzene. The molecule's most mechanically active parts are the carboxyl and amine groups. They exhibit rocking, swinging, and every kind of mechanical motion beside H immigrations between each other. For this reason, the molecule is not a simple carboxylic acid nor a primary amine[1].
Uses
It is used in the preparation of hepatitis C virus NS5b RNA polymerase inhibitors. Also used in the determination of cobalt, copper, nickel, and zinc.
Uses
2-Amino-5-bromobenzoic acid is a brominated derivative of Antharilinic Acid (A679222). 2-Amino-5-bromobenzoic acid displays plant growth-regulator activity. 2-Amino-5-bromobenzoic acid is used in the preparation of hepatitis C virus NS5b RNA polymerase inhibitors.
Preparation
2-Amino-5-bromobenzoic acid is synthesized from o-aminobenzoic acid by bromination.
Synthesis of 2-amino-5-bromobenzoic acid (4c, CAS: 5794-88-7) and 2-amino3,5-dibromobenzoic acid (4d, CAS: 609-85-8): A solution of bromine (7.2 g, 2 mL, 40 mmol) in 47 mL glacial acetic acid was added dropwise to sodium 2-aminobenzoate (6.4 g, 40 mmol) in 32 mL of glacial acetic acid at 15 °С and the mixture was stirred for 1 h at the same temperature. The product was filtered off, washed with benzene and dried in the dark. The bromobenzoic acids containing mixture (0.5 g) was added to 10 mL of boiling water followed by the addition of 1.3 mL of concentrated hydrochloric acid and hot filtration under vacuum. The insoluble material contained 2-amino-3,5-dibromobenzoic acid, whereas 2- amino-5-bromobenzoic acid precipitated upon cooling of the filtrate.
2-Amino-5-bromobenzoic acid (4c) IR (suspension in nujol, cm?1 ): 3497, 3383, 1675, 1616, 1587, 1548, 1423, 1377, 1316, 1292, 1239, 1160, 1127, 812, 748, 691.
References
[1] Kunduracioglu, Ahmet . "Tautomeric Forms of 2–Amino–5–Bromobenzoic Acid: A DFT Study for Structural and Molecular Orbital Analysis." (2021).
2-Amino-5-bromobenzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
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Changzhou Jiuwu Chemical co., Ltd. | +86-0519-85121086 +8613775162768 | info@jiuwuchem.cn | China | 75 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12495 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20291 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21663 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 906 | 58 |
View Lastest Price from 2-Amino-5-bromobenzoic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-01-02 | 2-Amino-5-bromobenzoic acid
5794-88-7
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | ||
2023-08-08 | 2-Amino-5-bromobenzoic acid
5794-88-7
|
US $0.00 / kg | 1kg | 99% | 20ton | Hebei Mojin Biotechnology Co., Ltd | ||
2023-01-31 | 2-Amino-5-bromobenzoic acid
5794-88-7
|
US $100.00 / kg | 1kg | 99 | 300tons | Hebei Mojin Biotechnology Co., Ltd |
- 2-Amino-5-bromobenzoic acid
5794-88-7
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
- 2-Amino-5-bromobenzoic acid
5794-88-7
- US $0.00 / kg
- 99%
- Hebei Mojin Biotechnology Co., Ltd
- 2-Amino-5-bromobenzoic acid
5794-88-7
- US $100.00 / kg
- 99
- Hebei Mojin Biotechnology Co., Ltd