D-Pantethine | 16816-67-4

D-Pantethine Properties

alpha	D27 +13.5° (c = 3.75 in water)
Boiling point	987.2±65.0 °C(Predicted)
Density	1.1949 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	2-8°C
solubility	Methanol (Slightly), Water (Slightly)
pka	12.71±0.20(Predicted)
form	syrup
color	Crystals from MeOH/Me2CO
Stability	Hygroscopic
InChIKey	DJWYOLJPSHDSAL-ROUUACIJSA-N
SMILES	S(CCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO
FDA UNII	7K81IL792L

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H400
Precautionary statements	P273-P391-P501
WGK Germany	3
RTECS	ES4392700
Toxicity	LD50 oral in rat: > 10gm/kg

D-Pantethine price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P2125	D-Pantethine analytical standard	16816-67-4	1g	$119	2024-03-01	Buy
Sigma-Aldrich	P2125	D-Pantethine analytical standard	16816-67-4	5g	$396	2024-03-01	Buy
TRC	P205823	D-Pantethine	16816-67-4	50mg	$45	2021-12-16	Buy
ChemScene	CS-4546	Pantethine 99.39%	16816-67-4	100mg	$60	2021-12-16	Buy
ChemScene	CS-4546	Pantethine 99.39%	16816-67-4	500mg	$84	2021-12-16	Buy

Product number	Packaging	Price	Buy
P2125	1g	$119	Buy
P2125	5g	$396	Buy
P205823	50mg	$45	Buy
CS-4546	100mg	$60	Buy
CS-4546	500mg	$84	Buy

D-Pantethine Chemical Properties,Uses,Production

Description

D-Pantethine is a compound in which two molecules of D-pantetheine bind through an S-S linkage. D-Pantethine is available from commercial sources as well as from D-pantothenic acid. It is known that the sulfhydryl group is the metabolically active part of the molecule. Coenzyme A is an essential cofactor in over 70 biological pathways, such as fatty acid oxidation, carbohydrate metabolism, and amino acid catabolism. Studies conducted in vitro suggest that D-Pantethine inhibits the activity of aldehyde dehydrogenase; however, related metabolites of the compound, such as Taurine (sc-202354), D-pantetheine, Coenzyme A, and D-pantothenate activate this enzyme.

Chemical Properties

Colorless to pale yellow, clear, viscous liquid

Originator

Atarone,Vinas

Uses

antilipemic

Definition

ChEBI: An organic disulfide that consists of two molecules of pantothenic acid linked by amide bonds to a cysteamine disulfide bridging group.

Manufacturing Process

To 11 g of hydrazine hydrate (85%) cooled in an ice bath are added 11.5 g of methyl d-pantothenate and the cold mixture is stirred vigorously. After the reaction takes place and the mixture is warmed to 30°C, it is allowed to stand at room temperature for two days, and then evaporated to dryness in vacuo at 50°C. The residue (14.7 g) of pantothenyl hydrazide is a clear glassy oil.
To 7.3 g of crude d-pantothenyl hydrazide dissolved in 21 ml of water and stirred in a beaker cooled on an ice bath is added sufficient. 6 N hydrochloric acid to shift the pH to 4. Then a solution of 1.7 g of sodium nitrite in 5 ml of water is added dropwise over a period of one hour, keeping the pH at 4 by additions of 6 N hydrochloric acid. After stirring for one-half hour, 2.8 g of bis(β-aminoethyl)disulfide dihydrochloride are added. The pH is then adjusted to 8.5 with 50% aqueous sodium hydroxide solution and the solution allowed to stir for one and one-half hours. It is then acidified to pH 7.5 and concentrated in vacuo to clear colorless viscous oil. The pure product can be isolated from this oil by the next method. The crude bis(Npantothenylamidoethyl)disulfide so obtained is purified by dissolving the crude reaction product in 45 ml of anhydrous n-butanol and pouring the resulting solution through a chromatograph column containing 272 g of activated carbon. The column is washed with n-butanol and fractions are collected from time to time and the fractions containing solids assaying about 25 to 40% pure bis(N-pantothenylamidoethyl)disulfide against Lactobacillus: helveticus 80 poured onto a chromatograph column containing 136 g of an alkaline earth aluminum silicate known commercially as Super -filtrol. The column is washed thoroughly with anhydrous n-butanol and the washings and main solution discarded. N-Butanol saturated with water is poured through the column to elute the bis(N-pantothenylamidoethyl)disulfide and the resulting solution evaporated to dryness in vacuum at low temperature to obtain the desired product in pure form.
Instead of pouring the anhydrous n-butanol solution onto the alkaline earth aluminum silicate chromatograph column, one can simply repeat the treatment with a carbon chromatograph column to obtain the pure product. In some instances, the first carbon treatment produces fractions containing pure bis(N-pantothenylamidoethyl)disulfide and in those cases it is, of course, not necessary to treat the fraction with alkaline earth aluminum silicate nor again with activated carbon.

Therapeutic Function

Growth factor, Antihyperlipidemic

Safety Profile

Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.

D-Pantethine Preparation Products And Raw materials

Raw materials

Carbon Hydrazine hydrate Methyl D-Pantothenate

Preparation Products

D-Pantethine Suppliers

Global( 179)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.	+86-029-86333380 18829239519	sales06@tgybio.com	China	902	58
PNP Biotech Co. Ltd	+8618516098983	sales@pnpbiotech.com	China	1001	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8618959220845	sales@amoychem.com	China	6383	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34553	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58

Supplier	Advantage
Alfa Chemistry	58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.	58
PNP Biotech Co. Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58

View Lastest Price from D-Pantethine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-25	D-Pantethine 16816-67-4	US $0.00 / Kg/Bag	2Kg/Bag	50% up / Food grade	20 tons	Sinoway Industrial co., ltd.
2024-11-19	Pantethine 16816-67-4	US $37.00-48.00 / mg		99.53%	10g	TargetMol Chemicals Inc.
2024-11-19	Pantethine 16816-67-4	US $37.00-48.00 / mg		99.53%	10g	TargetMol Chemicals Inc.

D-Pantethine
16816-67-4
US $0.00 / Kg/Bag
50% up / Food grade
Sinoway Industrial co., ltd.

Pantethine
16816-67-4
US $37.00-48.00 / mg
99.53%
TargetMol Chemicals Inc.

Pantethine
16816-67-4
US $37.00-48.00 / mg
99.53%
TargetMol Chemicals Inc.

D-Pantethine Spectrum

D-Pantethine(16816-67-4)MS

16816-67-4(D-Pantethine)Related Search:

3-Mercaptopropionic acid Sulfuryl chloride Diallyldisulfide Ethylamine Bismaleimide

Mercaptoacetic acid 2-Ethylhexyl mercaptoacetate Thiamine disulfide Sodium thiosulfate 2-AMINOETHANETHIOL

Glycine 2-Thiobarbituric acid Dithiooxamide ALTRENOGEST 3-Aminophenol

POTASSIUM THIOGLYCOLATE Calcium thioglycolate Tris(hydroxymethyl)aminomethane

1of4

bis(pantothenamidoethyl)disulfide butyramide,n,n’-(dithiobis(ethyleneiminocarbonylethylene))bis(2,4-dihydroxy-3, d-(+)-3-dimethyl d-bis(n-pantothenyl-beta-aminoethyl)disulfide d-pantethineanhydrous lbfdisulfide PANTETHIN Butanamide, N,N-dithiobis2,1-ethanediylimino(3-oxo-3,1-propanediyl)bis2,4-dihydroxy-3,3-dimethyl-, (2R,2R)- N-[2-[2-[2-[3-[(2,4-dihydroxy-3,3-dimethyl-butanoyl)amino]propanoylamino]ethyldisulfanyl]ethylcarbamoyl]ethyl]-2,4-dihydroxy-3,3-dimethyl-butanamide Butanamide, N,N'-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-, (2R,2'R)- (9CI) Butanamide, N,N'-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-, [R-(R*,R*)]- Butyramide, N,N'-[dithiobis(ethyleneiminocarbonylethylene)]bis[2,4-dihydroxy-3,3-dimethyl-, D-(+)- (8CI) D-Bis-pantothenyl-b-aminoethyl disulfide Lipodel Panthecin PANTETHINE BLEND 40% ACTIVE DRY POWDER Bis(N-pantothenylamidoethyl) disulfide, LBF factor, Pantethein oxidized form D-Pantethine hydrate (2R)-N-[3-[2-[2-[3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide Dermorizin N,N'-[Dithiobis(ethyleneiminocarbonylethylene)]bis(2,4-dihydroxy-3,3-dimethylbutyramide) D-Pantethine,Bis(N-pantothenylamidoethyl) disulfide, LBF factor, Pantethein oxidized form Pantethine Liquid [R-(R*,R*)]-N,N'-[dithiobis[ethyleneimino(3-oxopropane-3,1-diyl)]]bis[2,4-dihydroxy-3,3-dimethylbutyramide] N,N’-[dithiobis(ethyleneiminocarbonylethylene)]bis(2,4-dihydroxy-3,3-dimethyl-,D-(+)-Butyramide pantetina pantomin LBF FACTOR BIS[N-PANTOTHENYLAMIDOETHYL] DISULFIDE D-PANTETHINE Pantethine 80%Liquid Jp Bis-pantethine D-Pantethine USP/EP/BP 99% Purity D-Pantethine D-Pantethine(16816-67-4) D-pantethine syrup pantosin Patethine Pantethine, D-(P) D-pantethine Powder PANTETHINE, D- (2R,2'R)-N,N'-(((disulfanediylbis(ethane-2,1-diyl))bis(azanediyl))bis(3-oxopropane-3,1-diyl))bis(2,4-dihydroxy-3,3-dimethylbutanamide) (2R,2'R)-N,N'-(((Disulfanediylbis(ethane-2,1-diyl))bis(azanediyl))bis(3-oxopropane-3,1-diyl))bis(2,4-dihydroxy-3,3-dimethylbutanamide) 16816-67-4 C22H42N4O8S2 PA - PEN Analytical Chromatography Product Catalog Analytical Standards Alphabetic Inhibitors