2'-Deoxyadenosine
- CAS No.
- 958-09-8
- Chemical Name:
- 2'-Deoxyadenosine
- Synonyms
- DA;DEOXYADENOSINE;IFN-α;(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol;2'-dA;-dA CEP;2'-dA·H2O;DESOXYADENOSINE;8-Bromo-2’8-Amino-2&rsquo
- CBNumber:
- CB7162318
- Molecular Formula:
- C10H13N5O3
- Molecular Weight:
- 251.24
- MDL Number:
- MFCD00005754
- MOL File:
- 958-09-8.mol
- MSDS File:
- SDS
| Melting point | 187-189 °C |
|---|---|
| Boiling point | 394.4°C (rough estimate) |
| Density | 1.2938 (rough estimate) |
| refractive index | 1.7610 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| pka | pK1:3.8(+1) (25°C,μ=0.1) |
| form | powder |
| color | White |
| PH | 3.8 |
| Water Solubility | Soluble in water and caustic soda. |
| λmax | 258 (pH 2)；260 (pH 7) |
| Stability | Hygroscopic |
| InChI | InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 |
| InChIKey | OLXZPDWKRNYJJZ-RRKCRQDMSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)C[C@@H]1O |
| CAS DataBase Reference | 958-09-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | P582C98ULC |
| NIST Chemistry Reference | Deoxyadenosine(958-09-8) |
| EPA Substance Registry System | Adenosine, 2'-deoxy- (958-09-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AU7358600 | |||||||||
| F | 10-23 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
2'-Deoxyadenosine price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4137 | 2'-Deoxyadenosine Anhydrous >98.0%(HPLC)(T) | 958-09-8 | 5g | $131 | 2024-03-01 | Buy |
| Alfa Aesar | J63886 | 2'-Deoxyadenosine, 99% | 958-09-8 | 50g | $275 | 2024-03-01 | Buy |
| Alfa Aesar | J63886 | 2'-Deoxyadenosine, 99% | 958-09-8 | 100g | $515 | 2024-03-01 | Buy |
| Alfa Aesar | J63886 | 2'-Deoxyadenosine 99% | 958-09-8 | 5g | $28.65 | 2024-03-01 | Buy |
| Alfa Aesar | J63886 | 2'-Deoxyadenosine 99% | 958-09-8 | 25g | $151 | 2024-03-01 | Buy |
2'-Deoxyadenosine Chemical Properties,Uses,Production
Description
2'-Deoxyadenosine is a natural deoxyribonucleoside, which is a structural fragment of deoxyribonucleic acid DNA. It is a purine nucleoside component of DNA comprised of adenosine linked by its N9 nitrogen to the C1 carbon of deoxyribose. Like other natural nucleosides, it is involved in the transmission of genetic information in almost all biological cells, affecting protein synthesis and polysaccharide. It plays a very important role in regulating the growth, proliferation, differentiation and inhibition of cells in vivo.
Uses
2'-Deoxyadenosine is used in paradoxical stimulation study of human sperm motility. It plays an essential role as sperm motility stimulants used in sperm micro-injection on mouse and human embryo development. It finds an application in some cells as an energy source under energy stress conditions. It is involved in various biological processes to compare the functions of adenosine analogues.
Definition
ChEBI: 2'-deoxyadenosine is a purine 2'-deoxyribonucleoside having adenine as the nucleobase. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside.
Preparation
2'-deoxyadenosine synthesis: esterification of adenosine, acylation of an acylating agent and an acid binding agent to obtain an acylate; the obtained acylate is then subjected to reduction and purification to obtain 2'-deoxyadenosine. The esterification agent used in the esterification process is dialkyl tin oxide, 2'-O-p-toluenesulfonyladenosine is synthesized from adenosine, and 2'-deoxyadenosine is synthesized from 2'-O-p-toluenesulfonyladenosine glycosides.
Biological Functions
2'-Deoxyadenosine (Deoxyadenosine) is a critical component of DNA. When present in sufficiently high levels, deoxyadensoine can act as an immunotoxin and a metabotoxin. An immunotoxin disrupts, limits the function, or destroys immune cells. A metabotoxin is an endogenous metabolite that causes adverse health effects at chronically high levels.
Biological Activity
2'-Deoxyadenosine is a deoxyribonucleoside and an intermediate in the purine nucleotide degradation pathway. It is transported into cells via facilitated diffusion or formed within cells by degradation of S-adenosylhomocysteine or AMP and is removed from cells by purine metabolism or is converted into adenine nucleotides. 2'-Deoxyadenosine has been used in the characterization of DNA conformations and the synthesis of nucleoside analogs as antiviral agents.
Source
2'-Deoxyadenosine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). 2'-Deoxyadenosine is a natural product found in Streptomyces jiujiangensis, Fritillaria przewalskii, and other organisms with data available.
2'-Deoxyadenosine Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +undefined17756524438 | sales1@nuowei-chem.com | China | 1638 | 58 |
| Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
| SHANGHAI NOVRIBO BIOTECH | 17821030819 | June.Liu@Desano.com | China | 73 | 58 |
| Hangzhou Measure Life Technology Co., LTD | +8613343730176 | 2924244016@qq.com | China | 83 | 58 |
| Allbiosyn Biotechnology Co.,Ltd. | +8618666985712 | info@allbiosyn.com | China | 286 | 58 |
| Xinxiang Aurora Biotechnology Co.,Ltd. | +86-0086-0373-3088722 +8618637352520 | info@aurora-biotech.com | China | 89 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12837 | 58 |
| HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 | sales2@runyanpharma.com | China | 302 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21639 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32820 | 60 |
Related articles
- Synthesis and Bioactivity of 2'-Deoxyadenosine
- 2'-Deoxyadenosine can also be used as an important intermediate for antiviral, anticancer and anti-AIDS drugs.
- Sep 26，2022
View Lastest Price from 2'-Deoxyadenosine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-03 | 2'-Deoxyadenosine
958-09-8
|
US $0.00-0.00 / g | 10g | 99% HPLC | 10000 | HangZhou RunYan Pharma Technology Co.,LTD. | |
 |
2024-11-02 | 2'-Deoxyadenosine
958-09-8
|
US $1.00 / g | 10g | ≥98% | 10kgs/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-10-31 | 2'-Deoxyadenosine
958-09-8
|
US $55.00-39.00 / mg | 99.85% | 10g | TargetMol Chemicals Inc. |
-
- 2'-Deoxyadenosine
958-09-8
- US $0.00-0.00 / g
- 99% HPLC
- HangZhou RunYan Pharma Technology Co.,LTD.
-
- 2'-Deoxyadenosine
958-09-8
- US $1.00 / g
- ≥98%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2'-Deoxyadenosine
958-09-8
- US $55.00-39.00 / mg
- 99.85%
- TargetMol Chemicals Inc.
958-09-8(2'-Deoxyadenosine )Related Search:
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