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PKA Inhibitor Fragment (6-22) amide

PKA Inhibitor Fragment (6-22) amide structure

CAS No.: 121932-06-7

Chemical Name:: PKA Inhibitor Fragment (6-22) amide

Synonyms: PKI (6-22) AMIDE;TYADFIASGRTGRRNAI;PKA Inhibitor Fragme;PKA INHIBITOR PEPTIDE;TYADFIASGRTGRRNAI-NH2;PKA Inhibitor 6-22 Amide;PKI INHIBITOR (6-22), AMIDE;PKI 6-22 AMIDE, PKA INHIBITOR;PKA INHIBITOR FRAGMENT (6-22) AMIDE;PROTEIN KINASE INHIBITOR (6-22) AMIDE

CBNumber:: CB7180365

Molecular Formula:: C80H130N28O24

Molecular Weight:: 1868.06

MDL Number:: MFCD00133792

MOL File:: 121932-06-7.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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PKA Inhibitor Fragment (6-22) amide Properties

storage temp.	−20°C
solubility	≥186.8 mg/mL in DMSO; insoluble in EtOH; ≥44.9 mg/mL in H2O
form	Solid
Water Solubility	Soluble to 1 mg/ml in water

SAFETY

Risk and Safety Statements

WGK Germany	3

PKA Inhibitor Fragment (6-22) amide price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P6062	Protein Kinase A Inhibitor Fragment 6-22 amide ≥97% (HPLC)	121932-06-7	1mg	$271	2024-03-01	Buy
Sigma-Aldrich	539684	PKA Inhibitor 6-22 Amide	121932-06-7	1mg	$201	2024-03-01	Buy
Cayman Chemical	17486	PKA Inhibitor Fragment (6-22) amide	121932-06-7	500μg	$73	2024-03-01	Buy
Cayman Chemical	17486	PKA Inhibitor Fragment (6-22) amide	121932-06-7	1mg	$131	2024-03-01	Buy
Cayman Chemical	17486	PKA Inhibitor Fragment (6-22) amide	121932-06-7	5mg	$502	2024-03-01	Buy

Product number	Packaging	Price	Buy
P6062	1mg	$271	Buy
539684	1mg	$201	Buy
17486	500μg	$73	Buy
17486	1mg	$131	Buy
17486	5mg	$502	Buy

PKA Inhibitor Fragment (6-22) amide Chemical Properties,Uses,Production

Biological Activity

ki: 1.6 nmpka inhibitor fragment (6-22) amide is a pka inhibitor.in cell biology, protein kinase a (pka) is a family of enzymes whose activity is dependent on cellular levels of cyclic amp (camp). pka is also regarded as a camp-dependent protein kinase. pka has various functions in the cell, such as regulation of sugar, glycogen, and lipid metabolism.

in vitro

compared with (ala)kemptide, pka inhibitor fragment (6-22) amide was found to have significant difference in inhibitory potency, likely due to the critical role of several of the nonarginine residues to this difference in potency. the minimal length analog of pka inhibitor fragment (6-22) that inhibited camp-dependent protein kinase with high potency was the 17-residue pki-(6-22)-amide. pka inhibitor fragment (6-22) interacted at the peptide/protein binding portion of the active site in a competitive manner with a low nanomolar ki value. to inhibit camp-dependent protein kinase, pka inhibitor fragment (6-22) required both the pseudosubstrate site (residues 14-22) and additional nh2-terminal determinants within residues 6-13. pka inhibitor fragment (6-22) could clear mimic protein and peptide substrates in interacting with the binding region of the active site particularly in the cooh-terminal pseudosubstrate basic domain. undoubtedly, the overall affinity of pka inhibitor fragment (6-22) was due to the number of hydrogen bonds as well as other bonding interactions with the active site of the camp-dependent protein kinase [1, 2].

storage

-20°C (desiccate)

References

[1] glass et al (1989) primary structural determinants essential for potent inhibition of camp-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. j.biol.chem. 264 8802. pmid: 2722799.
[2] glass et al (1989) protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. j.biol.chem. 264 14579. pmid: 2760075.

PKA Inhibitor Fragment (6-22) amide Preparation Products And Raw materials

Raw materials

Preparation Products

PKA Inhibitor Fragment (6-22) amide Suppliers

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Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10311	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30239	58
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Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
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3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
BOC Sciences	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nanjing TGpeptide	58
Zhejiang Hangyu API Co., Ltd	58
Aladdin Scientific	58
Changsha MOL Changes Biotechnology Co., Ltd.	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69

PKA Inhibitor Fragment (6-22) amide Spectrum

PKA Inhibitor Fragment (6-22) amide(121932-06-7)MS

121932-06-7(PKA Inhibitor Fragment (6-22) amide)Related Search:

Pro-AMC PROTEASE INHIBITOR COCKTAIL, W/EDTA 1 VIAL PROTEASE-INHIBITOR-MIX G (31,2 MG) PROTEASE FROM ASPERGILLUS ORYZEA Ala-AMC

PROTEINASE K EC 3.4.24.4 PROTEASE LACTACYSTIN PROTEASE

EC 3.4.21.14 Proteinase K H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2 CAMP DEPENDENT PK INHIBITOR (5-24) AMIDE PKA Inhibitor Fragment (6-22) amide

H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-HIS-ASP-OH CAMP-DEPENDENT PROTEIN KINASE INHIBITOR (5-24) AMIDE PROTEIN KINASE A INHIBITOR FRAGMENT 5-24 AMIDE TRIFLUOROACETATE SALT

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PKA Inhibitor 6-22 Amide PROTEIN KINASE INHIBITOR (6-22) AMIDE PROTEIN KINASE A INHIBITOR FRAGMENT 6-22 AMIDE PROTEIN KINASE A INHIBITOR 6-22 AMIDE PKA INHIBITOR FRAGMENT (6-22) AMIDE PKA INHIBITOR PEPTIDE PKI INHIBITOR (6-22), AMIDE PKI (6-22) AMIDE PKI 6-22 AMIDE, PKA INHIBITOR THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2 TYADFIASGRTGRRNAI TYADFIASGRTGRRNAI-NH2 H-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2 PKA Inhibitor 6-22 Amide - CAS 121932-06-7 - Calbiochem L-Isoleucinamide, L-threonyl-L-tyrosyl-L-alanyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl- Protein Kinase A Inhibitor Fragment 6-22 amide >=97% (HPLC) PKA Inhibitor Fragment (6-22) amide USP/EP/BP PKA Inhibitor Fragme L-Isoleucinamide, L-threonyl-L-tyrosyl-L-alanyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl- PKA inhibitor fragment (6-22) amide TFA salt 121932-06-7 C80H130N28O24 Kinase/Phosphatase Biology Protein Kinase A (PKA) Serine/Threonine Kinase Inhibitors BioChemical Cell Biology Cell Signaling and Neuroscience SignalTransduction peptide Protein Kinase A (PKA)Cell Signaling and Neuroscience Protein Kinase Inhibitors and Related Products Kinase/Phosphatase Biology Protein Kinase Serine/Threonine Kinase Inhibitors Protein Kinase InhibitorsEnzymes, Inhibitors, and Substrates Protein Kinase InhibitorsPeptides for Cell Biology Protein Kinase Related Peptides Protein Kinases and Phosphatases Serine/Threonine Kinase Biology