dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate
- CAS No.
- 61330-09-4
- Chemical Name:
- dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate
- Synonyms
- dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate;Heptanedioic acid, 4-cyano-4-(3,4-dimethoxyphenyl)-, 1,7-dimethyl ester
- CBNumber:
- CB71949060
- Molecular Formula:
- C18H23NO6
- Molecular Weight:
- 349.38
- MDL Number:
- MFCD00110734
- MOL File:
- 61330-09-4.mol
dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate Chemical Properties,Uses,Production
Preparation
Dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate can be prepared by the following steps:A mixture of finely powdered 3,4- dimethoxyphenylacetonitrile 45 (5 g, 28.25 mmol) and TBAHSO4 (0.096 g, 0.28 mmol) in 10% aq. NaOH solution (20 ml) was stirred for 30 minutes at room temperature. A dark red colour appeared. The mixture was then cooled in an ice-bath. Methyl acrylate 239 was slowly added dropwise at 0 o C, (12.65 ml, 138.95 mmol). After 1 hour a colourless solid was formed, which was filtered and crystallized from EtOAc (7.49 g, 76% yield). Alternatively, dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate was prepared by refluxing a mixture of 3,4- dimethoxyphenylacetonitrile (100 g, 0.564 mol) and methyl acrylate (253 ml, 2.82 mol) in the presence of Triton-B (2.35 ml, 0.006 mol, 40% solution in MeOH) in CH3CN for overnight in almost quantitative yields (197 g).
dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate Preparation Products And Raw materials
Raw materials
Preparation Products
dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate Suppliers
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Interbioscreen Ltd. | -- | screen@ibscreen.chg.ru | Finland | 6178 | 60 |
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Interbioscreen Ltd. | 60 |
Specs | 70 |