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Cefazedone

Cefazedone structure

CAS No.: 56187-47-4

Chemical Name:: Cefazedone

Synonyms: REFOSPORIN;cefazedone;Refosporen;Cefoxitone;Ceftazidone;Cefazedone acid;(6r-trans)--8-oxo;CEFAZEDONE SODIUM;Cefazedone USP/EP/BP;(6R-trans)-Cefazedone

CBNumber:: CB7227198

Molecular Formula:: C18H15Cl2N5O5S3

Molecular Weight:: 548.44

MDL Number:: MFCD00864865

MOL File:: 56187-47-4.mol

Last updated:2024-11-19 23:02:33

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Cefazedone Properties

Melting point	157 - 160°C
Density	1.78±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	2.61±0.50(Predicted)
form	Solid
color	White to Off-White
CAS DataBase Reference	56187-47-4(CAS DataBase Reference)
FDA UNII	7Y86X0D799
ATC code	J01DB06

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS07
Signal word	Danger
Hazard statements	H361-H302-H372-H412
Precautionary statements	P264-P270-P301+P312-P330-P501-P273-P501-P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P314-P501

Cefazedone price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C241500	Cefazedone	56187-47-4	10mg	$145	2021-12-16	Buy
Usbiological	005849	Cefazedone	56187-47-4	10mg	$418	2021-12-16	Buy
Biosynth Carbosynth	FC19847	Cefazedone	56187-47-4	2g	$80	2021-12-16	Buy
ChemScene	CS-0079538	Cefazedone ≥98.0%	56187-47-4	25mg	$85	2021-12-16	Buy
Biosynth Carbosynth	FC19847	Cefazedone	56187-47-4	5G	$140	2021-12-16	Buy

Product number	Packaging	Price	Buy
C241500	10mg	$145	Buy
005849	10mg	$418	Buy
FC19847	2g	$80	Buy
CS-0079538	25mg	$85	Buy
FC19847	5G	$140	Buy

Cefazedone Chemical Properties,Uses,Production

Originator

Cefazedone Sodium,Arocor Holdings Inc.

Uses

Semi-synthetic cephalosporin antibiotic. Antibacterial.

Definition

ChEBI: A cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and [(3,5-dichloro-4-oxopyridin-1(4H)-yl)acetamido side-groups.

Manufacturing Process

A solution of 1 eq. of the tert-butyl ester of 7-aminocephalosporanic acid and 1 eq. of dicyclohexylcarbodiimide in 100 ml of methylene chloride/DMF (1:1) is cooled to 0°C. The mixture is combined with 1 eq. of 3,5-dichloro-4- pyridone-1-acetic acid; after 5 min the ice bath is removed and the mixture agitated for another 30 min at 25°C. The thus-formed urea is filtered off and the filtrate filtered over silica gel (eluent: ethyl acetate/1% methanol). The solvent is concentrated by evaporation, and the thus-obtained tert-butyl ester of 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid is crystallized from ether.
1 eq. of the tert-butyl ester is dissolved in 30 ml of trifluoroacetic acid. After 30 minutes, the solution is evaporated and the thus-produced 7-(3,5-dichloro- 1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid crystallized from ether.
1 eq. of the obtained 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido) cephalosporanic acid is dissolved in 60 ml of saturated aqueous sodium bicarbonate solution at a pH of below 7 and combined with 1 eq. of 5-methyl- 1,3,4-thiadiazole-2-thiol in 20 ml of acetone. The reaction solution is agitated for 2 hours at 80°C and at a pH of 6.3 under a nitrogen atmosphere. The acetone is thereupon removed, the solution is washed with ether and acidified to pH 2. The thus-obtained 3-(1-methyltetrazolyl-5-mercaptomethyl)-7-(3,5- dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)-3-cephem-4-carboxylic acid is filtered off and dried. IR spectrum confirmed the structure of cefazedone.
In practice it is usually used as sodium salt.

Therapeutic Function

Antibiotic

Cefazedone Preparation Products And Raw materials

Raw materials

Dicyclohexylcarbodiimide Trifluoroacetic acid 5-Methyl-1,3-benzenediacetonitrile 3,5-Dichloro-4-pyridone-N-acetic acid 2-Mercapto-5-methyl-1,3,4-thiadiazole

Preparation Products

Cefazedone Suppliers

Global( 193)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+8615350851019	admin@86-ss.com	China	1001	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8838	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12839	58

Supplier	Advantage
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
Shenzhen Excellent Biotech Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58

View Lastest Price from Cefazedone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-28	CEFAZEDONE SODIUM 56187-47-4	US $999.00-666.00 / kg	1kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2024-11-27	Cefazedone 56187-47-4	US $0.00-0.00 / kg	1kg	98%	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-19	Cefazedone 56187-47-4	US $50.00 / mg		99.39%	10g	TargetMol Chemicals Inc.

CEFAZEDONE SODIUM
56187-47-4
US $999.00-666.00 / kg
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Cefazedone
56187-47-4
US $0.00-0.00 / kg
98%
WUHAN FORTUNA CHEMICAL CO., LTD

Cefazedone
56187-47-4
US $50.00 / mg
99.39%
TargetMol Chemicals Inc.

56187-47-4(Cefazedone)Related Search:

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(6R,7R)-7-[[2-(3,5-Dichloro-4-oxo-1(4H)-pyridinyl)acetyl]aMino]-3-[[(5-Methyl-1,3,4- thiadiazol-2-yl)thio]Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid (6R-trans)-Cefazedone Cefazedone acid (6R,7R)-7-[[2-(3,5-dichloro-4-oxopyridin-1-yl)acetyl]amino]-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, (6R,7R)- (6r-trans)--8-oxo 1(4h)-pyridinyl)acetyl)amino)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl) 7-(((3,5-dichloro-4-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicaci cefazedone REFOSPORIN SODIUM-7-[3,5-DICHLORO-4-DIHYDROPYRIDYLACETYLAMINO]-3-[[(5-METHYL-1,3,4-THIADIAZOLYL)-THIO]METHYL]-3-CEPHEM-4-CARBOXYLATE CEFAZEDONE SODIUM REFOSPORIN[SODIUM-7-[3,5-DICHLORO-4-DIHYDROPYRIDYLACETYLAMINO]-3-[[(5-METHYL-1,3,4-THIADIAZOLYL)-THIO]METHYL]-3-CEPHEM-4-CARBOXYLATE] (6R,7R)-7-[(3,5-Dichloro-4-oxo-1(4H)-pyridyl)acetylamino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]octan-2-ene-2-carboxylic acid (6R,7R)-7-[2-(3,5-Dichloro-4-oxo-1(4H)-pyridyl)acetylamino]-3-[(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Refosporen (6R,7R)-7-(2-(3,5-Dichloro-4-oxo-1(4H)-pyridyl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Ceftazidone Cefoxitone (6R,7R)-7-(2-(3,5-dichloro-4-oxopyridin-1(4H)-yl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Cefazedone USP/EP/BP 3,5-Dichloro-4-hydroxypyridine，Cefazedone (6R,7R)-7-(2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Cefazedone Impurity) 56187-47-4 C18H15Cl2N5O5S3 C18H14N5O5Cl2NaS3 C18H19Cl2N5O5S3 Bases & Related Reagents Heterocycles Intermediates & Fine Chemicals Nucleotides Pharmaceuticals Sulfur & Selenium Compounds