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MK-2206 2HCl

MK-2206 2HCl structure

CAS No.: 1032350-13-2

Chemical Name:: MK-2206 2HCl

Synonyms: MK-2206;CS-260;MK-2206 2HCl;MK-2206 HCl salt;MK-2206 2HCL;MK2206;Benodanil Impurity 9;MK-2206 2HCl USP/EP/BP;MK-2206 Dihydrochloride;MK 2206 (hydrochloride);MK 2206 2HCL;MK2206 2HCL

CBNumber:: CB72489901

Molecular Formula:: C25H22ClN5O

Molecular Weight:: 443.94

MDL Number:: MFCD14584463

MOL File:: 1032350-13-2.mol

Last updated:2024-11-19 20:33:22

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MK-2206 2HCl Properties

Melting point	>255°C (dec.)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 10 mg/ml with warming)
form	Yellow powder.
color	Yellow
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
FDA UNII	Q34I3E28IO

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

HS Code

2933998090

NFPA 704

	0
2		0

MK-2206 2HCl price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	11593	MK-2206 (hydrochloride) ≥98%	1032350-13-2	1mg	$43	2024-03-01	Buy
Cayman Chemical	11593	MK-2206 (hydrochloride) ≥98%	1032350-13-2	5mg	$85	2024-03-01	Buy
Cayman Chemical	11593	MK-2206 (hydrochloride) ≥98%	1032350-13-2	10mg	$106	2024-03-01	Buy
Cayman Chemical	11593	MK-2206 (hydrochloride) ≥98%	1032350-13-2	25mg	$137	2024-03-01	Buy
Usbiological	M4095-40	MK-2206	1032350-13-2	500ug	$316	2021-12-16	Buy

Product number	Packaging	Price	Buy
11593	1mg	$43	Buy
11593	5mg	$85	Buy
11593	10mg	$106	Buy
11593	25mg	$137	Buy
M4095-40	500ug	$316	Buy

MK-2206 2HCl Chemical Properties,Uses,Production

Description

MK-2206 (CAS 1032350-13-2) is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the?in vitro?and?in vivo?antitumor efficacy of several standard chemotherapeutic agents.1?It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2?MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3

Uses

AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. Potent AKT inhibitor.

Uses

A highly selective inhibitor of Akt. Akt1, IC50=8 nM; Akt2, IC50=12 nM; Akt3, IC50=65 nM.

target

Akt1

storage

-20°C

References

1) Hirai?et al.?(2010),?MK-2206, an Allosteric Akt inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular targeted Drugs In vitro and In vivo; Mol. Cancer Ther.?9?1956 2) Lai?et al.?(2012),?A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle; Biochem. J.?447?137 3) Jiao?et al.?(2013),?MK-2206 induces cell cycle arrest and apoptosis in HepG2 cells and sensitizes TRAIL-mediated cell death; Mol. Cell Biochem.?382?217

MK-2206 2HCl Preparation Products And Raw materials

Raw materials

Preparation Products

MK-2206 2HCl Suppliers

Global( 202)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12840	58

Supplier	Advantage
Anhui Ruihan Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Hebei Mojin Biotechnology Co., Ltd	58

View Lastest Price from MK-2206 2HCl manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	MK-2206 dihydrochloride 1032350-13-2	US $30.00-64.00 / mg		99.91%	10g	TargetMol Chemicals Inc.
2023-09-07	MK-2206 2HCl 1032350-13-2	US $30.00 / kg	1kg	99%	1000t/year	Anhui Ruihan Technology Co., Ltd
2023-01-31	MK-2206 2HCl 1032350-13-2	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

MK-2206 dihydrochloride
1032350-13-2
US $30.00-64.00 / mg
99.91%
TargetMol Chemicals Inc.

MK-2206 2HCl
1032350-13-2
US $30.00 / kg
99%
Anhui Ruihan Technology Co., Ltd

MK-2206 2HCl
1032350-13-2
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

MK-2206 2HCl Spectrum

MK-2206 2HCl(1032350-13-2)¹HNMR

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MK-2206 Dihydrochloride 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride 8-[4-(1-AMinocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one Hydrochloride 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride MK-2206 MK-2206 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride MK 2206 (hydrochloride) MK-2206 dihydrochloride, >=98% MK-2206 2HCL;MK2206 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochlorideMK-2206 Dihydrochloride MK-2206 HCl salt 1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-, hydrochloride (1:2) MK-2206 2HCl MK 2206 2HCL;MK2206 2HCL CS-260 MK2206; MK-2206; MK 2206; MK2206 DIHYDROCHLORIDE; MK2206 HCL. (8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one) dihydrochloride MK 2206 dihydrochloride, 98%, an allosteric Akt inhibitor 8-[4-(1-AMINOCYCLOBUTYL)PHENYL]-9-PHENYL-1,2,4-TRIAZOLO[3,4-F][1,6]NAPHTHYRIDIN-3(2H)-ONE 2HCL MK 2206 2HCL;MK2206 2HCL;MK-2206 DIHYDROCHLORIDE;MK2206 DIHYDROCHLORIDE MK-2206 2HCl USP/EP/BP MK-2206 MK-2206 2HCl/MK-2206 dihydrochloride MK-2206 dihydrochloride MK2206 MK-2206 DIHYDROCHLORIDE SALT (2XHCL SALT) Benodanil Impurity 9 1032350-13-2 C25H21N5O2HCl C25H23Cl2N5O C25H21N5O2ClH Inhibitor PI3K/Akt/mTOR Inhibitors Akt mTOR PI3K Amines Heterocycles Intermediates & Fine Chemicals Pharmaceuticals