Vilazodone Hydrochloride
- CAS No.
- 163521-08-2
- Chemical Name:
- Vilazodone Hydrochloride
- Synonyms
- CS-796;EMD 68843;SB 659746A;Vilazodone HCl, >=98%;4-Methylenedioxyphenol;Vilazodone hydrochloride;Vilazodone HCl (EMD 68843;Vilazodone hydrochloride API;Vera trazodone hydrochloride;Vilazodone hydrochloride salt
- CBNumber:
- CB72521214
- Molecular Formula:
- C26H28ClN5O2
- Molecular Weight:
- 477.98582
- MDL Number:
- MFCD00940014
- MOL File:
- 163521-08-2.mol
- MSDS File:
- SDS
| Melting point | 279°C(lit.) |
|---|---|
| Flash point | 9℃ |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| Stability | Hygroscopic |
| FDA UNII | U8HTX2GK8J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361d | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25 | |||||||||
| Safety Statements | 7-16-36/37-45 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
Vilazodone Hydrochloride price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1098 | Vilazodone hydrochloride ≥98% (HPLC) | 163521-08-2 | 10mg | $70.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1098 | Vilazodone hydrochloride ≥98% (HPLC) | 163521-08-2 | 50mg | $289 | 2024-03-01 | Buy |
| TCI Chemical | V0149 | Vilazodone Hydrochloride >98.0%(HPLC) | 163521-08-2 | 50mg | $236 | 2024-03-01 | Buy |
| TCI Chemical | V0149 | Vilazodone Hydrochloride >98.0%(HPLC) | 163521-08-2 | 200mg | $657 | 2024-03-01 | Buy |
| Cayman Chemical | 21547 | Vilazodone (hydrochloride) ≥95% | 163521-08-2 | 50mg | $93 | 2024-03-01 | Buy |
Vilazodone Hydrochloride Chemical Properties,Uses,Production
Description
Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50s = 0.2 and 0.5 nM, respectively). It increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex when administered intraperitoneally at doses of 1 and 3 mg/kg. Vilazodone (1 mg/kg, i.p.) decreases immobility in the forced swim test in both rats and mice. Formulations containing vilazodone have been used in the treatment of depression.
Uses
Vilazodone Hydrochloride, is the salt form of Vilazodone (V265000), which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. Antidepressant.
Definition
ChEBI: A hydrochloride obtained by reaction of vilazodone with one equivalent of hydrochloric acid. Used for the treatment of major depressive disorder.
Clinical Use
Althoughseveral synthetic approaches have beenreported,a process-scale synthesis of vilazodone consists of the union of an indole-containing butyl tosylate 284 with a benzofuranyl piperazine whose synthesis is described in the scheme below. Piperazine 280 arises from a Buchwald coupling of commercially available benzofuranyl bromide 279 with piperazine through the use of a unique catalyst system employing the DavePhos ligand. This single coupling step, which has been executed on multigram scale in 70% yield,210 circumvented the need for any protecting group chemistry for either the primary amide within 279 or the piperazine amine functionality. For the preparation of the key indole subunit, Friedel-Crafts acylation of commercially available 5-cyanoindole (281) proceeded in good yield at the 3-position of the indole with 4-chlorobutanoyl chloride in 82% yield. Treatment of the resulting chloroketone with sodium borohydride in refluxing isopropanol converted 282 to the corresponding terminal alcohol 283. Tosylation of this alcohol was followed by displacement with piperazine 280 to give vilazodone hydrochloride (XXV) after acidification.
Synthesis
Vilazodone hydrochloride is a combined serotonin reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist marketed under the trade name Viibryd.202 Viibryd was developed by Merck KGaA (Germany) and approved for the treatment of depression by the U.S. FDA on January 21st, 2011. Vilazodone has been shown to be well-tolerated at higher dosage levels, specifically by not causing significant weight gain or decreased sexual desire or function, which are improvements over existing antidepressant treatments.
storage
Store at -20°C
Vilazodone Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 | sales001@rokechem.com | China | 255 | 58 |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 444 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9210 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
View Lastest Price from Vilazodone Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-22 | Vilazodone Hydrochloride
163521-08-2
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-19 | Vilazodone Hydrochloride
163521-08-2
|
US $40.00-83.00 / mg | 99.92% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-18 | Vilazodone Hydrochloride
163521-08-2
|
US $0.00 / g | 1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. |
-
- Vilazodone Hydrochloride
163521-08-2
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Vilazodone Hydrochloride
163521-08-2
- US $40.00-83.00 / mg
- 99.92%
- TargetMol Chemicals Inc.
-
- Vilazodone Hydrochloride
163521-08-2
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.