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BIX01294 (hydrochloride hydrate)

BIX01294 (hydrochloride hydrate) Structure
BIX01294 (hydrochloride hydrate) structure
CAS No.
1808255-64-2
Chemical Name:
BIX01294 (hydrochloride hydrate)
Synonyms
BIX01294 (hydrochloride hydrate);BIX01294 (hydrochloride hydrate),BIX-01294 (hydrochloride hydrate);2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine,trihydrochloride,hydrate
CBNumber:
CB72590339
Molecular Formula:
C28H41ClN6O3
Molecular Weight:
545.13
MDL Number:
MOL File:
1808255-64-2.mol
Last updated:2023-05-21 10:59:17
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BIX01294 (hydrochloride hydrate) Properties

storage temp. Store at -20°C
solubility DMSO: 5 mg/ml; Water: 10 mg/ml
form A crystalline solid

BIX01294 (hydrochloride hydrate) price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13124 BIX01294 (hydrochloride hydrate) ≥98% 1808255-64-2 1mg $30 2024-03-01 Buy
Cayman Chemical 13124 BIX01294 (hydrochloride hydrate) ≥98% 1808255-64-2 5mg $113 2024-03-01 Buy
Cayman Chemical 13124 BIX01294 (hydrochloride hydrate) ≥98% 1808255-64-2 10mg $169 2024-03-01 Buy
Cayman Chemical 13124 BIX01294 (hydrochloride hydrate) ≥98% 1808255-64-2 50mg $558 2024-03-01 Buy
Product number Packaging Price Buy
13124 1mg $30 Buy
13124 5mg $113 Buy
13124 10mg $169 Buy
13124 50mg $558 Buy

BIX01294 (hydrochloride hydrate) Chemical Properties,Uses,Production

Description

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development.1,2,3 BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM).4 It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known HMTases.4 BIX01294 has been used in combination with the calcium channel activator BayK8644 to facilitate the generation of induced pluripotent stem cells from somatic cells in vitro.5

References

1. Tachibana, M., Sugimoto, K., Nozaki, M., et al. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis Genes Dev. 16(14),1779-1791(2002).
2. Wagschal, A., Sutherland, H.G., Woodfine, K., et al. G9a histone methyltransferase contributes to imprinting in the mouse placenta Mol. Cell Biol. 28(3),1104-1113(2008).
3. Thomas, L.R., Miyashita, H., Cobb, R.M., et al. Functional analysis of histone methyltransferase G9a in B and T lymphocytes J. Immunol. 181(1),485-493(2008).
4. Kubicek, S., O'Sullivan, R.J., August, E.M., et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase Mol. Cell 25,473-481(2007).
5. Shi, Y., Desponts, C., Do, J.T., et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds Cell Stem Cell 3(5),568-574(2008).

BIX01294 (hydrochloride hydrate) Preparation Products And Raw materials

Raw materials

Preparation Products

BIX01294 (hydrochloride hydrate) Suppliers

Global( 22)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd 15658004993 1900830611@qq.com China 956 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
LEAPCHEM CO., LTD. 		58
BOC Sciences 65
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
BIX01294 (hydrochloride hydrate) BIX01294 (hydrochloride hydrate),BIX-01294 (hydrochloride hydrate) 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine,trihydrochloride,hydrate 1808255-64-2