Palmitoyl Serotonin
- CAS No.
- 212707-51-2
- Chemical Name:
- Palmitoyl Serotonin
- Synonyms
- Palmitoyl Serotonin;Palmitoyl Serotonin Exclusive;N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]hexadecanamide;Hexadecanamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-
- CBNumber:
- CB72591952
- Molecular Formula:
- C26H42N2O2
- Molecular Weight:
- 414.62
- MDL Number:
- MFCD18382130
- MOL File:
- 212707-51-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Palmitoyl Serotonin price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9000630 | Palmitoyl Serotonin ≥98% | 212707-51-2 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 9000630 | Palmitoyl Serotonin ≥98% | 212707-51-2 | 50mg | $310 | 2024-03-01 | Buy |
| Cayman Chemical | 9000630 | Palmitoyl Serotonin ≥98% | 212707-51-2 | 100mg | $570 | 2024-03-01 | Buy |
| Cayman Chemical | 9000630 | Palmitoyl Serotonin ≥98% | 212707-51-2 | 1mg | $53 | 2021-12-16 | Buy |
| Cayman Chemical | 9000630 | Palmitoyl Serotonin ≥98% | 212707-51-2 | 10mg | $82 | 2024-03-01 | Buy |
Palmitoyl Serotonin Chemical Properties,Uses,Production
Definition
ChEBI: N-palmitoylserotonin is an N-acylserotonin obtained by formal condensation of the carboxy group of hexadecanoic acid with the primary amino group of serotonin. It is functionally related to a hexadecanoic acid.
Biological Activity
palmitoyl serotonin is a trpv1 antagonist with ic50 value of 0.76 μm for human trpv1 [1].the transient receptor potential vanilloid-type 1 (trpv1) channel is a nonselective cation channel that may be activated by a variety of exogenous and endogenous physical and chemical stimuli. trpv1 is decreased in the injured nerve fibers but increased in those proximal to the site damage. trpv1 is a potential new target for the development of analgesic and anti-inflammatory drugs [1].palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. arachidonoyl serotonin is a dual antagonist of trpv1 and fatty acid amide hydrolase (faah) with ic50 values of 0.27 and 8 μm, respectively. arachidonoyl serotonin was highly effective against both acute and chronic peripheral pain [1][2]. in trpv1 and faah assays, palmitoyl serotonin inhibited anandamide hydrolysis mediated by faah and capsaicin-induced intracellular ca2+ elevation in hek293 cells overexpressing the human recombinant trpv1 receptor with ic50 values of > 50 μm and 0.76 μm, respectively. however, the effects of replacing the arachidonoyl portion with the saturated 16-carbon palmitoyl moiety had not been studied [1].
References
[1]. ortar g, cascio mg, de petrocellis l, et al. new n-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. j med chem. 2007 dec 27;50(26):6554-69.
[2]. maione s, de petrocellis l, de novellis v, et al. analgesic actions of n-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid trpv1 receptors. br j pharmacol. 2007 mar;150(6):766-81.
Palmitoyl Serotonin Preparation Products And Raw materials
Raw materials
Preparation Products
Palmitoyl Serotonin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| SHANGHAI ZZBIO CO., LTD. | 13916577892 19921389125 | tech@zzbioco.com | China | 12063 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
| Supplier | Advantage |
|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| MedBioPharmaceutical Technology Inc | 58 |
| SHANGHAI ZZBIO CO., LTD. | 58 |
| ApexBio Technology | 58 |