Difluoromethyl 2-pyridyl sulfone
- CAS No.
- 1219454-89-3
- Chemical Name:
- Difluoromethyl 2-pyridyl sulfone
- Synonyms
- 2-PySO2CF2H;2-[(DifL;Hu Reagent;DFM-2-pyridyl sulfone;2-Pyridyl difluoromethyl sulfone;DifluoroMethyl 2-Pyridyl Sulfone;2-(Difluoromethanesulfonyl)pyridine;2-[(DifluoroMethyl)sulfonyl]pyridine;Pyridine, 2-[(difluoroMethyl)sulfonyl]-;Difluoromethyl 2-pyridyl sulfone 97% (HPLC)
- CBNumber:
- CB72614473
- Molecular Formula:
- C6H5F2NO2S
- Molecular Weight:
- 193.17
- MDL Number:
- MFCD17010193
- MOL File:
- 1219454-89-3.mol
- MSDS File:
- SDS
Melting point | 47.0 to 51.0 °C |
---|---|
Boiling point | 324.4±42.0 °C(Predicted) |
Density | 1.423±0.06 g/cm3(Predicted) |
storage temp. | -20°C Freezer, Under inert atmosphere |
solubility | Chloroform (Slightly), Methanol (Slightly) |
pka | -2.60±0.19(Predicted) |
form | Solid |
color | Off-White |
BRN | 20317604 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H301-H319 | |||||||||
Precautionary statements | P301+P310-P305+P351+P338 | |||||||||
Hazard Codes | T | |||||||||
Risk Statements | 25-36 | |||||||||
Safety Statements | 26-45-24/25 | |||||||||
RIDADR | UN 2811 6.1 / PGIII | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
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Difluoromethyl 2-pyridyl sulfone price More Price(14)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 746061 | Difluoromethyl 2-pyridyl sulfone 97% (HPLC) | 1219454-89-3 | 1g | $137 | 2024-03-01 | Buy |
Sigma-Aldrich | 746061 | Difluoromethyl 2-pyridyl sulfone 97% (HPLC) | 1219454-89-3 | 5g | $643 | 2024-03-01 | Buy |
TCI Chemical | D5390 | Difluoromethyl 2-Pyridyl Sulfone >98.0%(GC) | 1219454-89-3 | 1g | $117 | 2024-03-01 | Buy |
TRC | D446180 | 2-[(Difluoromethyl)sulfonyl]pyridine | 1219454-89-3 | 1g | $110 | 2021-12-16 | Buy |
TRC | D446180 | 2-[(Difluoromethyl)sulfonyl]pyridine | 1219454-89-3 | 5g | $255 | 2021-12-16 | Buy |
Difluoromethyl 2-pyridyl sulfone Chemical Properties,Uses,Production
Description
Difluoromethyl 2-pyridyl sulfone, also known as Hu reagent, is a novel and efficient gem-difluoroolefination reagent for preparing gem-difluoroalkenes from both aldehydes and ketones. The fluorinated sulfinate intermediates during the gem-difluoroolefination is relatively stable, and can be halogenated in situ to afford bromo- and iododifluoromethyl compounds. It can also act as nucleophilic difluoro(sulfonato)methylation reagent for the synthesis of α,α-difluorosulfonates from aldehydes, and alkyl halides and triflates.
Chemical Properties
Melting point 48-50°C, boiling point 324.4+42°C, relative density 1.423+0.06 g/cm3 , slightly soluble in water, casily soluble in acctonitrile and methanol.
Uses
Reagent is used in the olefination of ketones and aldehydes to form gem-difluoro olefins under basic conditions. Product is also used as a crucial intermediate toward making 1,1-difluorinated alkyl chains for the alkylation of heterocycles.
Uses
2-[(Difluoromethyl)sulfonyl]pyridine is a new novel gem-difluoroolefination reagent for both aldehydes and ketones.
Application
- Difluoromethyl 2-pyridyl sulfone can be used for the introduction of difluoromethylene, as a difluoroalkylation reagent to reacwith aldehydes and ketones to prepare difluoroalkenesIt can be used for the introduction of difluoromethyl, reacting with aryl zine and aryl iodine to preparedifluoromethyl aryl compounds, and conducting free radical addition reactions with olefins.
- It can be used as a nucleophilic difluoro (sulfonation) methylation reagent for synthesis from aldehydes.ketones, alkyl halides, trifluoromethanesulfonic acid esters, etc a,a- Difluoroalkyl sulfinates andsulfonates.
- It can also be used together with electrophilic iodination reagents and bromination reagents for theintroduction ofmonoiododifluoromethyl and monobromodifluoromethyl groups.
- It can also be used as a 2-pyridylation reagent.
Reactions
(1) gem-Difluoroolefination of aldehydes and ketones.
(2) Halodifluoromethylation of aldehydes and ketones.
(3) (Fluorosulfonyl)difluoromethylation of aldehydes and ketones.
(4) Difluoro(sulfonato)methylation of alkyl halides and triflates.
(5) Aromatic difluoromethylation
General Description
Difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) is a reagent used in the gem-difluoroolefination of aldehydes and ketones. It is also used as a reagent in the nucleophilic difluoro(sulfonato)methylation of alcohols, N-sulfinyl imines, and halides.
References
[1] WENJUN MIAO. Nickel-Catalyzed Reductive 2-Pyridination of Aryl Iodides with Difluoromethyl 2-Pyridyl Sulfone[J]. Organic Letters, 2021, 23 3: 711-715. DOI:10.1021/acs.orglett.0c03939.
[2] WENJUN MIAO. Nucleophilic Iododifluoromethylation of Carbonyl Compounds Using Difluoromethyl 2-Pyridyl Sulfone[J]. Organic Letters, 2016, 18 11: 2766-2769. DOI:10.1021/acs.orglett.6b01258.
[3] YANCHUAN ZHAO. Difluoromethyl 2-Pyridyl Sulfone: A New gem-Difluoroolefination Reagent for Aldehydes and Ketones[J]. Organic Letters, 2010, 12 7: 1444-1447. DOI:10.1021/ol100090r.
Difluoromethyl 2-pyridyl sulfone Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10978 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10318 | 58 |
Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29826 | 58 |
Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5791 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
View Lastest Price from Difluoromethyl 2-pyridyl sulfone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-05-10 | Difluoromethyl 2-pyridyl sulfone
1219454-89-3
|
US $0.10-0.10 / kg | 0.0005kg | 99% | 20 tons | Zibo Hangyu Biotechnology Development Co., Ltd | ||
2020-01-17 | Pyridine, 2-[(difluoroMethyl)sulfonyl]-
1219454-89-3
|
US $3.00 / KG | 1KG | 98% | 1kg,5kg,50kg | Career Henan Chemical Co |
- Difluoromethyl 2-pyridyl sulfone
1219454-89-3
- US $0.10-0.10 / kg
- 99%
- Zibo Hangyu Biotechnology Development Co., Ltd
- Pyridine, 2-[(difluoroMethyl)sulfonyl]-
1219454-89-3
- US $3.00 / KG
- 98%
- Career Henan Chemical Co