ChemicalBook >> CAS DataBase List >>N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- structure

CAS No.: 1263369-28-3

Chemical Name:: N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-

Synonyms: CDK9-IN-2;CDK9 inhibitor 2;inhibit,Inhibitor,Cyclin dependent kinase,CDK,CDK9IN2,CDK9 IN 2,CDK-9-IN-2;N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine;N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine;N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-;N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-[(3-fluorophenyl)methyl]-[2,4'-bipyridine]-2',6-diamine;[2,4'-Bipyridine]-2',6-diamine, N2'-(trans-4-aminocyclohexyl)-5'-chloro-N6-[(3-fluorophenyl)methyl]-

CBNumber:: CB72666609

Molecular Formula:: C23H25ClFN5

Molecular Weight:: 425.93

MDL Number:: MFCD25562908

MOL File:: 1263369-28-3.mol

Last updated:2024-10-30 18:52:02

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N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Properties

Boiling point	603.1±55.0 °C(Predicted)
Density	1.302±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 50 mg/mL (117.39 mM; Need ultrasonic)
form	Powder
pka	10.40±0.70(Predicted)
color	Light yellow to yellow

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-1252	CDK9-IN-2 99.84%	1263369-28-3	5mg	$240	2021-12-16	Buy
ChemScene	CS-1252	CDK9-IN-2 99.84%	1263369-28-3	10mg	$360	2021-12-16	Buy
ApexBio Technology	A3295	CDK9inhibitor2	1263369-28-3	5mg	$419	2021-12-16	Buy
ApexBio Technology	A3295	CDK9inhibitor2	1263369-28-3	10mg	$541	2021-12-16	Buy
ChemScene	CS-1252	CDK9-IN-2 99.84%	1263369-28-3	50mg	$960	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-1252	5mg	$240	Buy
CS-1252	10mg	$360	Buy
A3295	5mg	$419	Buy
A3295	10mg	$541	Buy
CS-1252	50mg	$960	Buy

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Chemical Properties,Uses,Production

Description

CDK9-IN-2 is a special cyclin-dependent kinase 9 (CDK9) inhibitor, extracted from patent WO/2012131594A1, compound CDKI(8), has an IC50 of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively.

in vitro

In Vitro:CDK9-IN-2 (200 nM) reduces the expression of MEPCE indicating that MEPCE is a pharmacodynamic (PD) marker for any CDK9 inhibitor. The expression of MCL1 protein is reduced 2 hours after treatment and is further reduced after 16 hour exposure to CDK9-IN-2 (500 nM)[1].

References

References:[1]. Michel Faure, et al. Pharmacodynamic markers associated with cyclin-dependent kinase inhibitors. From PCT Int. Appl. (2012), WO 2012131594A1.

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Preparation Products And Raw materials

Raw materials

Preparation Products

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Suppliers

Global( 48)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32024	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30241	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38463	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49979	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Hefei Hirisun Pharmatech Co., Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58

View Lastest Price from N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-30	CDK9-IN-2 1263369-28-3	US $48.00-178.00 / mg		99%	10g	TargetMol Chemicals Inc.
	2024-10-30	CDK9-IN-2 1263369-28-3	US $48.00-178.00 / mg		99%	10g	TargetMol Chemicals Inc.

CDK9-IN-2
1263369-28-3
US $48.00-178.00 / mg
99%
TargetMol Chemicals Inc.

CDK9-IN-2
1263369-28-3
US $48.00-178.00 / mg
99%
TargetMol Chemicals Inc.

CDK9 inhibitor 2 N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- CDK9-IN-2 N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-[(3-fluorophenyl)methyl]-[2,4'-bipyridine]-2',6-diamine [2,4'-Bipyridine]-2',6-diamine, N2'-(trans-4-aminocyclohexyl)-5'-chloro-N6-[(3-fluorophenyl)methyl]- inhibit,Inhibitor,Cyclin dependent kinase,CDK,CDK9IN2,CDK9 IN 2,CDK-9-IN-2 N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine 1263369-28-3 C23H25ClFN5