LDK-378 dihydrochloride
- CAS No.
- 1380575-43-8
- Chemical Name:
- LDK-378 dihydrochloride
- Synonyms
- LDK378 2Hcl;5-Chloro-N4-[;Ceritinib 2hcl;Ceritinib diHCl;Ceritinib intermediate;Ceritinib Hydrochloride;LDK 378 dihydrochloride;LDK-378 dihydrochloride;LDK378 2HCl (Ceritinib);LDK378 (dihydrochloride)
- CBNumber:
- CB72666649
- Molecular Formula:
- C28H37Cl2N5O3S
- Molecular Weight:
- 594.6
- MDL Number:
- MFCD26142928
- MOL File:
- 1380575-43-8.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | ≥12.38 mg/mL in EtOH with ultrasonic; ≥13.7 mg/mL in H2O; ≥29.65 mg/mL in DMSO |
| form | Powder |
| color | Light yellow to yellow |
| FDA UNII | 08381UU98P |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
LDK-378 dihydrochloride price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1407 | Ceritinibdihydrochloride 99.83% | 1380575-43-8 | 5mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-1407 | Ceritinibdihydrochloride 99.83% | 1380575-43-8 | 10mg | $70 | 2021-12-16 | Buy |
| ChemScene | CS-1407 | Ceritinibdihydrochloride 99.83% | 1380575-43-8 | 50mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | A3544 | LDK378dihydrochloride | 1380575-43-8 | 5mg | $103 | 2021-12-16 | Buy |
| ChemScene | CS-1407 | Ceritinibdihydrochloride 99.83% | 1380575-43-8 | 100mg | $150 | 2021-12-16 | Buy |
LDK-378 dihydrochloride Chemical Properties,Uses,Production
Biological Activity
ldk378 is a highly potent inhibitor of anaplastic lymphoma kinase (alk), which is a receptor tyrosine kinase belonging to the superfamily of insulin receptor, with half maximal inhibitory concentration ic50 of 200 pm. ldk378 also exhibits modest to high inhibition against a panel of other kinases, in which only three kinases with ic50 below 100 nm includes igf-1r (8 nm), insr (7 nm) and stk22d (23 nm). in previous studies, ldk378 has been found to inhibit the proliferation of ba/f3 cells transfected with the npm-alk fusion gene and karpas 299 human non-hodgkin’s ki-positivr large cell lymphoma harboring the npm-alk fusion gene with ic50 of 22.8 nm and 26 nm.
References
[1]chen j, jiang c, wang s. ldk378: a promising anaplastic lymphoma kinase (alk) inhibitor. j med chem. 2013 jul 25;56(14):5673-4. doi: 10.1021/jm401005u. epub 2013 jul 9.
[2]marsilje th, pei w, chen b, lu w, uno t, jin y, jiang t, kim s, li n, warmuth m, sarkisova y, sun f, steffy a, pferdekamper ac, li ag, joseph sb, kim y, liu b, tuntland t, cui x, gray ns, steensma r, wan y, jiang j, chopiuk g, li j, gordon wp, richmond w, johnson k, chang j, groessl t, he yq, phimister a, aycinena a, lee cc, bursulaya b, karanewsky ds, seidel hm, harris jl, michellys py. synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (alk) inhibitor 5-chloro-n2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-n4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (ldk378) currently in phase 1 and phase 2
LDK-378 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 | sales04@yibaibiotech.com | CHINA | 419 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13415 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
View Lastest Price from LDK-378 dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-26 | Ceritinib dihydrochloride
1380575-43-8
|
US $0.00-0.00 / kg | 0.1kg | 99.5%(HPLC); Each single impurity<0.1% | 1500kg/Year | Nanjing Fred Technology Co., Ltd | |
 |
2024-11-19 | Ceritinib dihydrochloride
1380575-43-8
|
US $43.00-71.00 / mg | 99.99% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-07-22 | Ceritinib dihydrochloride
1380575-43-8
|
US $0.00-0.00 / KG | 1g | 99.0% | 500kg/month | Beijing Yibai Biotechnology Co., Ltd |
-
- Ceritinib dihydrochloride
1380575-43-8
- US $0.00-0.00 / kg
- 99.5%(HPLC); Each single impurity<0.1%
- Nanjing Fred Technology Co., Ltd
-
- Ceritinib dihydrochloride
1380575-43-8
- US $43.00-71.00 / mg
- 99.99%
- TargetMol Chemicals Inc.
-
- Ceritinib dihydrochloride
1380575-43-8
- US $0.00-0.00 / KG
- 99.0%
- Beijing Yibai Biotechnology Co., Ltd
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