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GSK 2830371

GSK 2830371 structure

CAS No.: 1404456-53-6

Chemical Name:: GSK 2830371

Synonyms: GSK 2830371;GSK 2830371 USP/EP/BP;GSK 2830371, 10 mM in DMSO;(S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophenecarboxamide;2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-;GSK 2830371 (S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino) -1-oxopropan-2-yl)thiophene-2-carboxamide

CBNumber:: CB72682001

Molecular Formula:: C23H29ClN4O2S

Molecular Weight:: 461.02

MDL Number:: MFCD28009442

MOL File:: 1404456-53-6.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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GSK 2830371 Properties

Boiling point	704.1±60.0 °C(Predicted)
Density	1.30±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble20mg/mL, clear
pka	13.29±0.46(Predicted)
form	powder
color	white to beige
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	3

GSK 2830371 price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1048	GSK2830371 ≥98% (HPLC)	1404456-53-6	5mg	$123	2024-03-01	Buy
Sigma-Aldrich	SML1048	GSK2830371 ≥98% (HPLC)	1404456-53-6	25mg	$476	2024-03-01	Buy
Cayman Chemical	16973	GSK2830371 ≥98%	1404456-53-6	1mg	$32	2024-03-01	Buy
Cayman Chemical	16973	GSK2830371 ≥98%	1404456-53-6	5mg	$100	2024-03-01	Buy
Cayman Chemical	16973	GSK2830371 ≥98%	1404456-53-6	10mg	$184	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1048	5mg	$123	Buy
SML1048	25mg	$476	Buy
16973	1mg	$32	Buy
16973	5mg	$100	Buy
16973	10mg	$184	Buy

GSK 2830371 Chemical Properties,Uses,Production

Uses

GSK 2830371 is used in biological studies as allosteric Wip1(wild-type p54-induced phosphatase) inhibition through flap-subdomain interaction.

Biochem/physiol Actions

GSK2830371 is an orally active allosteric inhibitor of wild-type p53-induced phosphatase (Wip1, also known as PPM1D/ PP2Cδ), an oncogenic type 2C serine/threonine phosphatase that negatively regulates key proteins in the DNA damage–response pathway. GSK2830371 is selective for Wip1 with an IC50 of 6 nM against Wip1 compared to >10 μM IC50 for PPM1A & PPM1K, and >30 μM IC50 for 22 other phosphatases tested. GSK2830371 is believed to interact with the flap subdomain located near the Wip1 catalytic site, a feature that distinguishes Wip1 from other members of the protein phosphatase 2C (PP2C) family. GSK2830371 increased phosphorylation of Wip1 substrates and caused growth inhibition in both hematopoietic tumor cell lines and Wip1-amplified breast tumor cells harboring wild-type TP53.

storage

Store at -20°C

GSK 2830371 synthesis

Synthesis of GSK 2830371 from 2,5-Dichloro-3-nitropyridine

GSK 2830371 Preparation Products And Raw materials

Raw materials

2,5-Dichloro-3-nitropyridine 2-Thiophenecarboxylic acid, 5-[[(5-chloro-2-Methyl-3-pyridinyl)aMino]Methyl]- 3-Amino-5-chloropicoline (S)-tert-butyl (3-cyclopentyl-1-(cyclopropylaMino)-1-oxopropan-2-yl)carbaMate 5-Chloro-2-methyl-3-nitropyridine

Preparation Products

GSK 2830371 Suppliers

Global( 119)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22787	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10986	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58

Supplier	Advantage
Hubei Jusheng Technology Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Aladdin Scientific	58

View Lastest Price from GSK 2830371 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	GSK 2830371 1404456-53-6	US $48.00-153.00 / mg		99.3%	10g	TargetMol Chemicals Inc.

GSK 2830371
1404456-53-6
US $48.00-153.00 / mg
99.3%
TargetMol Chemicals Inc.

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GSK 2830371 5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophenecarboxamide (S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide GSK 2830371 USP/EP/BP 2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]- 5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide GSK 2830371 (S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino) -1-oxopropan-2-yl)thiophene-2-carboxamide GSK 2830371, 10 mM in DMSO 1404456-53-6 C23H29ClN4O2S Inhibitors