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CH5138303

CH5138303 Structure
CH5138303 structure
CAS No.
959763-06-5
Chemical Name:
CH5138303
Synonyms
CH5138303;CH5138303cas;CH5138303_Hsp90;CH5138303 USP/EP/BP;4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide;4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide;4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid;Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-;4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide
CBNumber:
CB72706190
Molecular Formula:
C19H18ClN5O2S
Molecular Weight:
415.9
MDL Number:
MFCD28099815
MOL File:
959763-06-5.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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CH5138303 Properties

Boiling point 813.1±75.0 °C(Predicted)
Density 1.51±0.1 g/cm3(Predicted)
storage temp. Desiccate at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥19.95 mg/mL in DMSO
form solid
pka 16.39±0.40(Predicted)

CH5138303 price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22417 CH5138303 ≥99% 959763-06-5 1mg $117 2024-03-01 Buy
Cayman Chemical 22417 CH5138303 ≥99% 959763-06-5 5mg $404 2024-03-01 Buy
ApexBio Technology B4571 CH5138303 959763-06-5 1mg $67 2021-12-16 Buy
AK Scientific 2164AH 4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[DE]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamide 959763-06-5 1mg $228 2021-12-16 Buy
ApexBio Technology B4571 CH5138303 959763-06-5 5mg $237 2021-12-16 Buy
Product number Packaging Price Buy
22417 1mg $117 Buy
22417 5mg $404 Buy
B4571 1mg $67 Buy
2164AH 1mg $228 Buy
B4571 5mg $237 Buy

CH5138303 Chemical Properties,Uses,Production

Description

CH5138303 is a triazine Hsp90 inhibitor. CH5138303 binds to the N-terminus of Hsp90α (Kd = 0.52 nM) and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC50s = 89 and 66 nM, respectively). CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts (ED50 = 3.9 mg/kg) and displays high oral bioavailability in mice.

target

Hsp90

References

[1]. suda a, kawasaki k, komiyama s, et al. design and synthesis of 2-amino-6-(1h,3h-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel hsp90 inhibitors. bioorg med chem, 2014, 22(2): 892-905.

CH5138303 Preparation Products And Raw materials

Raw materials

Preparation Products

CH5138303 Suppliers

Global( 53)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 27537 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42057 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4428 55
Supplier Advantage
Hubei xin bonus chemical co. LTD 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Boyle Chemical Co., Ltd. 55
Guangzhou Isun Pharmaceutical Co., Ltd 55

959763-06-5(CH5138303)Related Search:

BIIB-021 Panobinostat 5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methyl-4-piperidinyl)-3-isoxazolecarboxamide NVP-HSP990(HSP990) Luminespib
17-AAG

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CH5138303 Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]- 4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide 4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide 4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid CH5138303_Hsp90 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide CH5138303 USP/EP/BP CH5138303cas 959763-06-5 Inhibitors