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CH5138303

CH5138303 structure

CAS No.: 959763-06-5

Chemical Name:: CH5138303

Synonyms: CH5138303;CH5138303cas;CH5138303_Hsp90;CH5138303 USP/EP/BP;4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide;4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide;4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid;Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-;4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide

CBNumber:: CB72706190

Molecular Formula:: C19H18ClN5O2S

Molecular Weight:: 415.9

MDL Number:: MFCD28099815

MOL File:: 959763-06-5.mol

MSDS File:: SDS

Last updated:2024-07-02 08:55:16

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CH5138303 Properties

Boiling point	813.1±75.0 °C(Predicted)
Density	1.51±0.1 g/cm3(Predicted)
storage temp.	Desiccate at -20°C
solubility	insoluble in H2O; insoluble in EtOH; ≥19.95 mg/mL in DMSO
form	solid
pka	16.39±0.40(Predicted)
color	White to off-white

CH5138303 price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	22417	CH5138303 ≥99%	959763-06-5	1mg	$117	2024-03-01	Buy
Cayman Chemical	22417	CH5138303 ≥99%	959763-06-5	5mg	$404	2024-03-01	Buy
ApexBio Technology	B4571	CH5138303	959763-06-5	1mg	$67	2021-12-16	Buy
AK Scientific	2164AH	4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[DE]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamide	959763-06-5	1mg	$228	2021-12-16	Buy
ApexBio Technology	B4571	CH5138303	959763-06-5	5mg	$237	2021-12-16	Buy

Product number	Packaging	Price	Buy
22417	1mg	$117	Buy
22417	5mg	$404	Buy
B4571	1mg	$67	Buy
2164AH	1mg	$228	Buy
B4571	5mg	$237	Buy

CH5138303 Chemical Properties,Uses,Production

Description

CH5138303 is a triazine Hsp90 inhibitor. CH5138303 binds to the N-terminus of Hsp90α (K_d = 0.52 nM) and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC₅₀s = 89 and 66 nM, respectively). CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts (ED₅₀ = 3.9 mg/kg) and displays high oral bioavailability in mice.

target

Hsp90

References

[1]. suda a, kawasaki k, komiyama s, et al. design and synthesis of 2-amino-6-(1h,3h-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel hsp90 inhibitors. bioorg med chem, 2014, 22(2): 892-905.

CH5138303 Preparation Products And Raw materials

Raw materials

Preparation Products

CH5138303 Suppliers

Global( 48)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22783	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2922	55
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55

Supplier	Advantage
Hubei xin bonus chemical co. LTD	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55
Guangzhou Isun Pharmaceutical Co., Ltd	55

959763-06-5(CH5138303)Related Search:

BIIB-021 Panobinostat 5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methyl-4-piperidinyl)-3-isoxazolecarboxamide NVP-HSP990(HSP990) Luminespib

17-AAG

1of2

CH5138303 Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]- 4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide 4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide 4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid CH5138303_Hsp90 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide CH5138303 USP/EP/BP CH5138303cas 959763-06-5 Inhibitors