CAY10683 (SantacruzaMate A)
- CAS No.
- 1477949-42-0
- Chemical Name:
- CAY10683 (SantacruzaMate A)
- Synonyms
- SantacruzaMate A;CAY10683;Santacruzamate A (CAY10683);CAY1083;CS-1702;8-Trihydroxyflavone;CAY 10683;CAY-10683;Santacruzamate A, >98%;CAY10683 (SantacruzaMate A);SantacruzaMate A, 10 mM in DMSO
- CBNumber:
- CB72716623
- Molecular Formula:
- C15H22N2O3
- Molecular Weight:
- 278.35
- MDL Number:
- MFCD28348356
- MOL File:
- 1477949-42-0.mol
| Boiling point | 508.1±43.0 °C(Predicted) |
|---|---|
| Density | 1.087±0.06 g/cm3(Predicted) |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml). |
| form | solid |
| pka | 12.68±0.46(Predicted) |
| color | Off-white |
| Stability | Stable for 2 years from date of purchse as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
CAY10683 (SantacruzaMate A) price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15403 | CAY10683 ≥95% | 1477949-42-0 | 5mg | $47 | 2024-03-01 | Buy |
| Cayman Chemical | 15403 | CAY10683 ≥95% | 1477949-42-0 | 10mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 15403 | CAY10683 ≥95% | 1477949-42-0 | 25mg | $171 | 2024-03-01 | Buy |
| Cayman Chemical | 15403 | CAY10683 ≥95% | 1477949-42-0 | 50mg | $315 | 2024-03-01 | Buy |
| Tocris | 7191 | SantacruzamateA ≥98%(HPLC) | 1477949-42-0 | 10 | $69 | 2021-12-16 | Buy |
CAY10683 (SantacruzaMate A) Chemical Properties,Uses,Production
Description
Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4
Uses
Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.
Definition
ChEBI: Santacruzamate A is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.
IC 50
HDAC2: 119 pM (IC50); HDAC6: 434 nM (IC50)
storage
Store at -20°C
References
1) Pavlik?et al.?(2013),?Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.; J. Nat. Prod.,?76?2026 2) Zhou?et al.?(2018),?Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma; Cell Prolif.,?51(3)?e12447 3) Damaskos?et al.?(2017),?Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer;?Anticancer Res.,?37?35 4) Chen?et al.?(2019),?Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro;?Front. Cell. Neurosci.,?13?61
CAY10683 (SantacruzaMate A) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from CAY10683 (SantacruzaMate A) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | SantacruzaMate A
1477949-42-0
|
US $30.00-53.00 / mg | 99.55% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-09-06 | CAY10683 (SantacruzaMate A)
1477949-42-0
|
US $1.00 / KG | 1KG | 95%~99% | per week 100kg | Career Henan Chemical Co |
-
- SantacruzaMate A
1477949-42-0
- US $30.00-53.00 / mg
- 99.55%
- TargetMol Chemicals Inc.
-
- CAY10683 (SantacruzaMate A)
1477949-42-0
- US $1.00 / KG
- 95%~99%
- Career Henan Chemical Co