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CAY10683 (SantacruzaMate A)

CAS No.
1477949-42-0
Chemical Name:
CAY10683 (SantacruzaMate A)
Synonyms
SantacruzaMate A;CAY10683;Santacruzamate A (CAY10683);CAY1083;CS-1702;8-Trihydroxyflavone;CAY 10683;CAY-10683;Santacruzamate A, >98%;CAY10683 (SantacruzaMate A);SantacruzaMate A, 10 mM in DMSO
CBNumber:
CB72716623
Molecular Formula:
C15H22N2O3
Molecular Weight:
278.35
MDL Number:
MFCD28348356
MOL File:
1477949-42-0.mol
Last updated:2025-01-27 09:38:02

CAY10683 (SantacruzaMate A) Properties

Boiling point 508.1±43.0 °C(Predicted)
Density 1.087±0.06 g/cm3(Predicted)
storage temp. -20°
solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
form solid
pka 12.68±0.46(Predicted)
color Off-white
Stability Stable for 2 years from date of purchse as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

CAY10683 (SantacruzaMate A) price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15403 CAY10683 ≥95% 1477949-42-0 5mg $47 2024-03-01 Buy
Cayman Chemical 15403 CAY10683 ≥95% 1477949-42-0 10mg $73 2024-03-01 Buy
Cayman Chemical 15403 CAY10683 ≥95% 1477949-42-0 25mg $171 2024-03-01 Buy
Cayman Chemical 15403 CAY10683 ≥95% 1477949-42-0 50mg $315 2024-03-01 Buy
Tocris 7191 SantacruzamateA ≥98%(HPLC) 1477949-42-0 10 $69 2021-12-16 Buy
Product number Packaging Price Buy
15403 5mg $47 Buy
15403 10mg $73 Buy
15403 25mg $171 Buy
15403 50mg $315 Buy
7191 10 $69 Buy

CAY10683 (SantacruzaMate A) Chemical Properties,Uses,Production

Description

Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4

Uses

Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.

Definition

ChEBI: Santacruzamate A is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.

storage

Store at -20°C

References

1) Pavlik?et al.?(2013),?Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.; J. Nat. Prod.,?76?2026 2) Zhou?et al.?(2018),?Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma; Cell Prolif.,?51(3)?e12447 3) Damaskos?et al.?(2017),?Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer;?Anticancer Res.,?37?35 4) Chen?et al.?(2019),?Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro;?Front. Cell. Neurosci.,?13?61

CAY10683 (SantacruzaMate A) Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 95)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29863 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific
tp@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58

View Lastest Price from CAY10683 (SantacruzaMate A) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SantacruzaMate A pictures 2024-11-19 SantacruzaMate A
1477949-42-0
US $30.00-53.00 / mg 99.55% 10g TargetMol Chemicals Inc.
CAY10683 (SantacruzaMate A) pictures 2019-09-06 CAY10683 (SantacruzaMate A)
1477949-42-0
US $1.00 / KG 1KG 95%~99% per week 100kg Career Henan Chemical Co

CAY10683 (SantacruzaMate A) Spectrum

CAY10683 (SantacruzaMate A) ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid ethyl ester CAY1083 Carbamic acid, N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-, ethyl ester Santacruzamate A, >98% CAY 10683;CAY-10683 CS-1702 8-Trihydroxyflavone Santacruzamate A (CAY10683) SantacruzaMate A CAY10683 SantacruzaMate A, 10 mM in DMSO 1477949-42-0 Inhibitors