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CAY10683 (SantacruzaMate A)

CAS No.
1477949-42-0
Chemical Name:
CAY10683 (SantacruzaMate A)
Synonyms
SantacruzaMate A;CAY10683;Santacruzamate A (CAY10683);CAY1083;CS-1702;8-Trihydroxyflavone;CAY 10683;CAY-10683;Santacruzamate A, >98%;CAY10683 (SantacruzaMate A);ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE
CBNumber:
CB72716623
Molecular Formula:
C15H22N2O3
Molecular Weight:
278.35
MDL Number:
MFCD28348356
MOL File:
1477949-42-0.mol
Last updated:2024-11-19 23:02:33

CAY10683 (SantacruzaMate A) Properties

Boiling point 508.1±43.0 °C(Predicted)
Density 1.087±0.06 g/cm3(Predicted)
storage temp. -20°
solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
form solid
pka 12.68±0.46(Predicted)
color Off-white
Stability Stable for 2 years from date of purchse as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

SAFETY

Risk and Safety Statements

CAY10683 (SantacruzaMate A) price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15403 CAY10683 ≥95% 1477949-42-0 5mg $47 2024-03-01 Buy
Cayman Chemical 15403 CAY10683 ≥95% 1477949-42-0 10mg $73 2024-03-01 Buy
Cayman Chemical 15403 CAY10683 ≥95% 1477949-42-0 25mg $171 2024-03-01 Buy
Cayman Chemical 15403 CAY10683 ≥95% 1477949-42-0 50mg $315 2024-03-01 Buy
Tocris 7191 SantacruzamateA ≥98%(HPLC) 1477949-42-0 10 $69 2021-12-16 Buy
Product number Packaging Price Buy
15403 5mg $47 Buy
15403 10mg $73 Buy
15403 25mg $171 Buy
15403 50mg $315 Buy
7191 10 $69 Buy

CAY10683 (SantacruzaMate A) Chemical Properties,Uses,Production

Description

Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4

Uses

Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.

Definition

ChEBI: Santacruzamate A is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.

storage

Store at -20°C

References

1) Pavlik?et al.?(2013),?Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.; J. Nat. Prod.,?76?2026 2) Zhou?et al.?(2018),?Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma; Cell Prolif.,?51(3)?e12447 3) Damaskos?et al.?(2017),?Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer;?Anticancer Res.,?37?35 4) Chen?et al.?(2019),?Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro;?Front. Cell. Neurosci.,?13?61

CAY10683 (SantacruzaMate A) Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 83)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58

View Lastest Price from CAY10683 (SantacruzaMate A) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SantacruzaMate A pictures 2024-11-19 SantacruzaMate A
1477949-42-0
US $30.00-53.00 / mg 99.55% 10g TargetMol Chemicals Inc.
CAY10683 (SantacruzaMate A) pictures 2019-09-06 CAY10683 (SantacruzaMate A)
1477949-42-0
US $1.00 / KG 1KG 95%~99% per week 100kg Career Henan Chemical Co

CAY10683 (SantacruzaMate A) Spectrum

CAY10683 (SantacruzaMate A) ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid ethyl ester CAY1083 Carbamic acid, N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-, ethyl ester Santacruzamate A, >98% CAY 10683;CAY-10683 CS-1702 8-Trihydroxyflavone Santacruzamate A (CAY10683) SantacruzaMate A CAY10683 1477949-42-0 Inhibitors