4-(tert-ButyldiMethylsilyloxy)butanal
- CAS No.
- 87184-81-4
- Chemical Name:
- 4-(tert-ButyldiMethylsilyloxy)butanal
- Synonyms
- 4-(tert-ButyldiMethylsilyloxy)butanal;4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]butanal;Butanal, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
- CBNumber:
- CB72721575
- Molecular Formula:
- C10H22O2Si
- Molecular Weight:
- 202.37
- MDL Number:
- MFCD12025097
- MOL File:
- 87184-81-4.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H335-H319-H315-H227 |
Precautionary statements | P210-P280-P370+P378-P403+P235-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
4-(tert-ButyldiMethylsilyloxy)butanal price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | T205913 | 4-(tert-Butyldimethylsilyloxy)butanal | 87184-81-4 | 10mg | $45 | 2021-12-16 | Buy |
Synthonix | B3803 | 4-(tert-Butyldimethylsilyloxy)butanal 95%+ | 87184-81-4 | 500mg | $150 | 2021-12-16 | Buy |
Synthonix | B3803 | 4-(tert-Butyldimethylsilyloxy)butanal 95%+ | 87184-81-4 | 1g | $275 | 2021-12-16 | Buy |
Matrix Scientific | 115667 | 4-(tert-Butyldimethylsilyloxy)butanal 95+% | 87184-81-4 | 500mg | $607 | 2021-12-16 | Buy |
Matrix Scientific | 115667 | 4-(tert-Butyldimethylsilyloxy)butanal 95+% | 87184-81-4 | 1g | $773 | 2021-12-16 | Buy |
4-(tert-ButyldiMethylsilyloxy)butanal Chemical Properties,Uses,Production
Synthesis
To a solution of oxalyl chloride (2.1 mL, 24 mmol, 1.2 equivalents) in CH2Cl2 (30 mL) cooled at −78 °C was added dropwise a solution of dimethylsulfoxide (DMSO 3.3 mL, 21 mmol, 1.1 equivalents) in CH2Cl2 (32 mL). After 5 min, a solution of 4-(tert-butyldimethylsilanyloxy)butan-1-ol (4.0 g, 20 mmol, 1.0 equivalents) in CH2Cl2 (26 mL) was added. The reaction mixture was then stirred for 15 min at −78 °C and triethylamine (14.0 mL, 100 mmol, 5.00 equivalents) was added in 1 portion. After 10 min at −78 °C, the mixture was allowed to warm to room temperature and diluted with CH2Cl2 (140 mL). The organic layer was successively washed with a saturated aqueous solution of NH4Cl (30 mL) and brine (2 × 30 mL). The combined organic extracts were dried over MgSO4, fifiltered, and concentrated under reduced pressure. Purifification by flflash chromatography on silica gel (petroleum ether/EtOAc: 90/10) afforded 3.88 g (96% yield) of the aldehyde as a colorless oil.
Reference: Taillier, C.; Gille, B.; Bellosta, V.; Cossy, J. J. Org. Chem. 2005, 70, 2097−2108.
4-(tert-ButyldiMethylsilyloxy)butanal Preparation Products And Raw materials
Raw materials
Preparation Products
4-(tert-ButyldiMethylsilyloxy)butanal Suppliers
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