Molidustat(BAY 85-3934)
- CAS No.
- 1154028-82-6
- Chemical Name:
- Molidustat(BAY 85-3934)
- Synonyms
- CS-1728;Somatoprim;MOLIDUSTAT;BAY 85-3934;Molidustat(BAY 85-3934);BAY 85-3934;BAY-85-3934;2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(triazol-1-yl)-1H-pyrazol-3-one;2-(6-morpholinopyrimidin-4-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-3(2H)-one;1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one;2-[6-(4-Morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one
- CBNumber:
- CB72729607
- Molecular Formula:
- C13H14N8O2
- Molecular Weight:
- 314.3
- MDL Number:
- MFCD28411428
- MOL File:
- 1154028-82-6.mol
| Boiling point | 589.2±60.0 °C(Predicted) |
|---|---|
| Density | 1.67±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in EtOH; insoluble in H2O; ≥5.68 mg/mL in DMF |
| form | solid |
| pka | 5.38±0.37(Predicted) |
| color | White to off-white |
| FDA UNII | 9JH486CZ13 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H372-H360-H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P260-P264-P270-P314-P501 | |||||||||
| NFPA 704 |
|
Molidustat(BAY 85-3934) price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15297 | BAY 85-3934 ≥95% | 1154028-82-6 | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 15297 | BAY 85-3934 ≥95% | 1154028-82-6 | 5mg | $137 | 2024-03-01 | Buy |
| Cayman Chemical | 15297 | BAY 85-3934 ≥95% | 1154028-82-6 | 10mg | $223 | 2024-03-01 | Buy |
| Cayman Chemical | 15297 | BAY 85-3934 ≥95% | 1154028-82-6 | 25mg | $396 | 2024-03-01 | Buy |
| ChemScene | CS-4046 | Molidustat 99.26% | 1154028-82-6 | 50mg | $400 | 2021-12-16 | Buy |
Molidustat(BAY 85-3934) Chemical Properties,Uses,Production
Description
Hypoxia-inducible factor (HIF) is the major transcription factor involved in erythropoietin gene expression. Because oxygen-
Uses
Molidustat (BAY 85-3934) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat can be utilized in the research of renal anemia[1][2].
in vitro
the ic50 values were found to be dependent on the 2-oxoglutarate concentration in the reaction buffer. by lowering the 2-oxoglutarate concentration from 20 μm to 0.3 μm, the potency of the test compound increased up to 10-fold. variation of the concentrations of fe2+ and ascorbate in the reaction buffer by factors of 30 and 200, respectively, did not alter the potency of the inhibitor by more than 2-fold [1].
in vivo
in repeat dosing of bay 85-3934, hemoglobin levels were increased compared with animals in vehicle group, while endogenous epo remained within the normal physiological range. bay 85-3934 therapy was also effective in the treatment of renal anemia in rats with impaired kidney function and, unlike treatment with rhepo, resulted in normalization of hypertensive blood pressure in a rat model of ckd [1].
IC 50
480 nm, 280 nm, and 450 nm for phd1, phd2, and phd3, respectively.
References
[1] flamme i, oehme f, ellinghaus p, jeske m, keldenich j, thuss u. mimicking hypoxia to treat anemia: hif-stabilizer bay 85-3934 (molidustat) stimulates erythropoietin production without hypertensive effects. plos one. 2014 nov 13;9(11):e111838.
Molidustat(BAY 85-3934) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
View Lastest Price from Molidustat(BAY 85-3934) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-01 | Molidustat ;BAY85-3934
1154028-82-6
|
US $0.00-0.00 / g | 1g | 98% | 100kgs | Wuhan Nutra Biotechnology Co.,Ltd | |
 |
2019-12-24 | Molidustat
1154028-82-6
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- Molidustat ;BAY85-3934
1154028-82-6
- US $0.00-0.00 / g
- 98%
- Wuhan Nutra Biotechnology Co.,Ltd
-
- Molidustat
1154028-82-6
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co