Finerenone
- CAS No.
- 1050477-31-0
- Chemical Name:
- Finerenone
- Synonyms
- Finerenone;BAY 94-8862;Finerone;(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide;BAY948862;Fenaridone;Fenalidone;Non Nilidone;Mr Neri ketone;Finerenone Inn
- CBNumber:
- CB72744895
- Molecular Formula:
- C21H22N4O3
- Molecular Weight:
- 378.42
- MDL Number:
- MFCD29047135
- MOL File:
- 1050477-31-0.mol
| Boiling point | 554.7±50.0 °C(Predicted) |
|---|---|
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 10 mg/ml DMSO: 3 mg/ml Ethanol: insol PBS (pH 7.2): insol |
| pka | 14.76±0.40(Predicted) |
| form | solid |
| color | White to off-white |
| λmax | 255 nm |
| InChI | InChI=1S/C21H22N4O3/c1-5-28-21-18-17(14-7-6-13(9-22)8-15(14)27-4)16(20(23)26)12(3)25-19(18)11(2)10-24-21/h6-8,10,17,25H,5H2,1-4H3,(H2,23,26)/t17-/m1/s1 |
| InChIKey | BTBHLEZXCOBLCY-QGZVFWFLSA-N |
| SMILES | N1C2=C(C(OCC)=NC=C2C)[C@H](C2=CC=C(C#N)C=C2OC)C(C(N)=O)=C1C |
| FDA UNII | DE2O63YV8R |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H360-H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| NFPA 704 |
|
Finerenone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0040097 | Finerenone 99.75% | 1050477-31-0 | 5mg | $480 | 2021-12-16 | Buy |
| ChemScene | CS-0040097 | Finerenone 99.75% | 1050477-31-0 | 10mg | $800 | 2021-12-16 | Buy |
| ChemScene | CS-0040097 | Finerenone 99.75% | 1050477-31-0 | 25mg | $1550 | 2021-12-16 | Buy |
| ChemScene | CS-0040097 | Finerenone 99.75% | 1050477-31-0 | 50mg | $2400 | 2021-12-16 | Buy |
| ChemScene | CS-0040097 | Finerenone 99.75% | 1050477-31-0 | 100mg | $3600 | 2021-12-16 | Buy |
Finerenone Chemical Properties,Uses,Production
Description
Finerenone is a novel mineralocorticoid receptor antagonist that has the effect of delaying the progression of chronic kidney disease. Some people may be aware of two other mineralocorticoid receptor antagonists: the diuretic antihypertensive drug spironolactone, and eplerenone.Finerenone is their cognate derivative and is a third-generation mineralocorticoid receptor antagonist. So far, finerenone is the only nonsteroidal mineralocorticoid receptor antagonist to be FDA approved. Finerenone was granted FDA approval on 9 July 2021, followed by the EMA approval on 11 March 2022.
Uses
Finerenone is the first non-steroidal selective mineralocorticoid receptor antagonist, which can be used for the treatment of diabetic nephropathy, chronic kidney disease and end-stage renal disease. It can reduce the proteinuria of patients and improve the glomerular filtration rate.
brand name
Finerenone is sold under the brand name Kerendia and Firialta.
Biological Activity
Finerenone (FIN, BAY 94-8862) is a highly selective, orally active, nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential to study cardio-renal diseases such as type 2 diabetes and chronic kidney disease.
in vivo
Finerenone (BAY 94-8862) lowers albuminuria by >40% and significantly reduces systolic blood pressure (SBP) in Munich Wistar Fr?mter (MWF) rat.
Mode of action
Finerenone is a Nonsteroidal Mineralocorticoid-Receptor Antagonist. The mechanism of action of finerenone is as a Mineralocorticoid Receptor Antagonist. Finerenone inhibits the effects of mineralocorticoids like aldosterone and cortisol when the MR is overactivated, possibly reducing inflammation and fibrosis in the heart and kidney.
References
Kolkhof, P., Hartmann, E., Freyberger, A., et al.Effects of finerenone combined with empagliflozin in a model of hypertension-induced end-organ damage. Am. J. Nephrol. 52(8), 642-652 (2021).
DOI: 10.1159/000516213
Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes.
Finerenone Preparation Products And Raw materials
Raw materials
Preparation Products
Finerenone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Mesochem Technology Co.,Ltd | +8613651027935 | rachel@mesochem.com | China | 191 | 58 |
| Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 | tracy.li@zisonpharm.com | China | 57 | 58 |
| Chengdu Aupone Pharmaceutical Co.Ltd. | +86-28-+86-28-87843998-6060-6060 +8618631098571 | lijiaqi@aupone.com | China | 54 | 58 |
| Auschemicals Pty Ltd | +61406202619 | info@auschemicals.com | Australia | 426 | 58 |
| Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd | +86-02223869539 +86-15560057295 | trade.kilopharma@foxmail.com | China | 27 | 58 |
| Beijing Hope Pharmaceutical Co., Ltd. | +86-010-67886402 +8613611125266 | market@hopelife.cn | China | 72 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 | sales@sdperfect.com | China | 294 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1001 | 58 |
| Zibo Wei Bin Import & Export Trade Co. Ltd. | +86-0533-2091136 +8613864437655 | ziboweibinmaoyi@163.com | China | 100 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
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- Jan 18，2024
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View Lastest Price from Finerenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-18 | Finerenone
1050477-31-0
|
US $0.00-0.00 / kg | 1kg | ＞99% by HPLC | 10kg/month | Zison Pharmaceutical (Shandong) Co., Ltd. | |
 |
2024-11-26 | Finerenone
1050477-31-0
|
US $0.00-0.00 / kg | 1kg | 99%，single impurity＜0.1 | 1 ton | Nanjing Fred Technology Co., Ltd | |
 |
2024-11-19 | Finerenone
1050477-31-0
|
US $0.00 / g | 1g | 98% HPLC | 100g | shandong perfect biotechnology co.ltd |
-
- Finerenone
1050477-31-0
- US $0.00-0.00 / kg
- ＞99% by HPLC
- Zison Pharmaceutical (Shandong) Co., Ltd.
-
- Finerenone
1050477-31-0
- US $0.00-0.00 / kg
- 99%，single impurity＜0.1
- Nanjing Fred Technology Co., Ltd
-
- Finerenone
1050477-31-0
- US $0.00 / g
- 98% HPLC
- shandong perfect biotechnology co.ltd