2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide
![2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide Structure](CAS/20180703/GIF/415687-81-9.gif)
- CAS No.
- 415687-81-9
- Chemical Name:
- 2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide
- Synonyms
- EGA;EGA >=98% (HPLC);2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide;Hydrazinecarboxamide, 2-[(4-bromophenyl)methylene]-N-(2,6-dimethylphenyl)-
- CBNumber:
- CB72750522
- Molecular Formula:
- C16H16BrN3O
- Molecular Weight:
- 346.22
- MDL Number:
- MFCD28118904
- MOL File:
- 415687-81-9.mol
| Density | 1.35±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/vial, clear (warmed) |
| form | powder |
| pka | 11.10±0.46(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H410-H315-H335 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P273-P391-P501 | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 36/37/38-50/53 | |||||||||
| Safety Statements | 26-36/37/39-60-61 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1006 | EGA ≥98% (HPLC) | 415687-81-9 | 5mg | $120 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1006 | EGA ≥98% (HPLC) | 415687-81-9 | 25mg | $476 | 2024-03-01 | Buy |
| Cayman Chemical | 21882 | EGA | 415687-81-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21882 | EGA | 415687-81-9 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 21882 | EGA | 415687-81-9 | 10mg | $153 | 2024-03-01 | Buy |
2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide Chemical Properties,Uses,Production
Description
EGA (415687-81-9) is a novel selective inhibitor of endosomal trafficking which blocks cellular entry of lethal toxin and other acid-dependent bacterial toxins and viruses into mammalian cells.1?Inhibits Anthrax lethal toxin-induced RAW264.7 cell death, IC50=1.7 mM.1 Delays lysosomal targeting and degradation of the EGF receptor indicating that it targets host membrane trafficking.1 Does not block endosomal recycling of transferrin, retrograde trafficking of ricin, phagolysosomal trafficking or phagosome permeabilization by Franciscella tularensis, nor does it neutralize acidic organelles.1 Protects mammalian cells from Clostridium difficile CDT, Clostridium perfringens Iota toxin and Clostridium botulinum C2 toxin.2 A useful tool for exploring subcellular trafficking of various bacterial toxins.3
Uses
EGA is a selective inhibitor of endosomol trafficking pathways exploited by multiple toxins and viruses.
References
Gillespie et al. (2013), Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses; Proc. Natl. Acad. Sci. USA, 110 E4904 Schnell et al. (2016), EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin; Toxins (Basel), 8 101 Dixon et al. (2015), Distinct Roles for CdtA and CdtC during Intoxication by Cytolethal Distending Toxins; PLoS One, 10 e0143977
2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32072 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30241 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | Sales@ATKchemical.com | China | 7045 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
