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4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide structure

CAS No.: 16673-34-0

Chemical Name:: 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

Synonyms: 5-Chloro-2-Methoxy-N-(4-sulfaMoylphenethyl)benzaMide;NLRP3i;NLRP3-IN-2;Einecs 240-722-5;16673-34-0 NLRP3i;Glyburide USP RC A;Glibenclamide Impurity 7;Glibenclamide EP Impurity A;Glyburide Related CoMpound A;NLRP3 Inflammasome InhibitorⅠ

CBNumber:: CB7278059

Molecular Formula:: C16H17ClN2O4S

Molecular Weight:: 368.84

MDL Number:: MFCD00193756

MOL File:: 16673-34-0.mol

MSDS File:: SDS

Last updated:2024-11-17 16:00:36

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4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Properties

Melting point	209-214 °C
Density	1.356±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in DMSO (up to 45 mg/ml).
form	Solid
pka	10.14±0.10(Predicted)
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI	InChI=1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)
InChIKey	KVWWTCSJLGHLRM-UHFFFAOYSA-N
SMILES	C(NCCC1=CC=C(S(N)(=O)=O)C=C1)(=O)C1=CC(Cl)=CC=C1OC
CAS DataBase Reference	16673-34-0(CAS DataBase Reference)
FDA UNII	8TF6P2NUB5

SAFETY

Risk and Safety Statements

Hazard Codes	T
Risk Statements	23-24-25
Safety Statements	24/25
WGK Germany	1
HS Code	2935909550

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2414	Glyburide Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material	16673-34-0	50MG	$534	2024-03-01	Buy
Sigma-Aldrich	BP071	4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonamide British Pharmacopoeia (BP) Reference Standard	16673-34-0	25MG	$266	2024-03-01	Buy
Sigma-Aldrich	463442	5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide 95%	16673-34-0	5g	$66	2024-03-01	Buy
Sigma-Aldrich	1295516	Glyburide Related Compound A United States Pharmacopeia (USP) Reference Standard	16673-34-0	25mg	$1490	2024-03-01	Buy
Cayman Chemical	30895	NLRP3i	16673-34-0	1g	$62	2024-03-01	Buy

Product number	Packaging	Price	Buy
PHR2414	50MG	$534	Buy
BP071	25MG	$266	Buy
463442	5g	$66	Buy
1295516	25mg	$1490	Buy
30895	1g	$62	Buy

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Chemical Properties,Uses,Production

Description

NLRP3i (16673-34-0) is an NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising?in vivo?protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2?Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2

Chemical Properties

Light Yellow Solid

Uses

An impurity arising in the synthesis of Glyburide (G598350).

General Description

5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide is an organic building block. It has been reported as an intermediate in the synthesis of glyburide. Synthesis of 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide has been reported.

storage

Store at +4°C

References

1) Fulp?et al.?(2018),?Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization; J. Med. Chem.,?61?5412 2) Marchetti?et al.?(2014),?A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse; J. Cardiovas. Pharmacol.,?63?316

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Preparation Products And Raw materials

Raw materials

5-CHLORO-2-METHOXYBENZOYL CHLORIDE 2-METHOXYBENZAMIDE 5-Chloro-2-hydroxybenzoic acid Thionyl chloride 5-Chloro-2-methoxybenzoic acid

Dimethyl sulfate

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Preparation Products

Glibenclamide

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Suppliers

Global( 199)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xiamen Shindano Biotechnology Co.,ltd	0592-6266840 15750707980	sales@chemsdano.com	China	291	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18777	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17365	58

Supplier	Advantage
Xiamen Shindano Biotechnology Co.,ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58

View Lastest Price from 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-17	NLRP3-IN-2 16673-34-0	US $53.00-41.00 / mg		98.98%	10g	TargetMol Chemicals Inc.
	2019-07-06	4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide 16673-34-0	US $1.00 / KG	1KG	95%-99%	1000kg	Career Henan Chemical Co

NLRP3-IN-2
16673-34-0
US $53.00-41.00 / mg
98.98%
TargetMol Chemicals Inc.

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
16673-34-0
US $1.00 / KG
95%-99%
Career Henan Chemical Co

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Spectrum

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide(16673-34-0)IR

16673-34-0(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide)Related Search:

Ethyl pyruvate P-AMINOBENZAMIDE GLUTAMIC ACID 2-(2-Aminoethylamino)ethanol Ethylparaben Ethyl acetate

Ethyl formate Ethyl cyanoacetate Ethanol Ethyl acrylate Sulfanilamide

Benzamide Diphenyl ether ISOXADIFEN-ETHYL PHENYL VALERATE PHENYL RESIN

Phenylacetic acid Difluorochloromethane Glibenclamide

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4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Glyburide Related Compound A (25 mg) (5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide) 4-[2-(2-Methoxy-5-chlorobenzene-1-carboxaMido)ethyl]benzenesulfonaMide 5-Chloro-N-(p-sulfaMoylphenethyl)-o-anisaMide GlibenclaMide (Glyburide) IMpurity A Glyburide Related CoMpound A Glyburide Related Compound A (25 mg) (4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide) Glyburide USP RC A 5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide 95% NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome InhibitorⅠ 5-chloro-2-methoxy-n-(2-(4-sulfamoyl-phenyl)ethyl N-(2-(4-(Aminosulfonyl)phenyl)ethyl)-5-chloro-2-methoxybenzamide 4-(5-CHLORO-2-METHOXYBENZAMIDOETHYL)BENZENESULFONAMIDE 4-[2-(5-CHLORO-2-METHOXY-BENZAMIDE)ETHYL]-BENZENESULPHONAMIDE 4-(2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL)PHENYLSULFONAMIDE 4-[2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL]PHENYLSULPHONAMIDE 4-[2-(2-METHOXY-5-CHLOROBENZAMIDO)ETHYL]BENZENESULFONAMIDE 5-CHLORO-2-METHOXY-N-[2-(P-SULFAMOYLPHENYL)ETHYL]BENZAMIDE 5-CHLORO-2-METHOXY-N-[2-(4-SULFAMOYLPHENYL)ETHYL]BENZAMIDE N-(2-(4-sulfamoyl)phenyl)ethyl-5-chloro-2-methoxybenzamide N-[2-[4-(aminosulphonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide 4-[2-(2-Methoxy-5-Chloro Benzamido)Ethyl]Sulphonamide [2-(5-Chloro-2.methoxybenzamido)-ethyl]-phenylsulfonamide 4-Ethyl-3-(2-methoxy-5-chlorbenzamido)-benzolsulfonamid 4-2-(5-CHLORO-2-METHOXYBENZAMIDO)-ETHYL BENZENSULFONAMIDE BENZAMIDE, N-[2-[4-(AMINOSULFONYL) PHENYL]ETHYL]-5-CHLORO-2-METHOXY (GLYBIN SULFONAMIDE) Einecs 240-722-5 N-[4-(Aminosulfonyl)phenethyl]-2-methoxy-5-chlorobenzamide 5-Chloro-2- methoxy-N-[2-(4-sulphamoylphenyl Glibenclamide Impurity 1(Glibenclamide EP Impurity A) NLRP3i Glyburide USP Related Compound A Glibenclamide (Glyburide) EP Impurity A Glibenclamide ImpurityⅠ:5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide 5-chloro-2-methoxy-N-[2-(4-sulphamoylphenyl)ethyl]benzamide Glibenclamide EP Impurity A 5-Chloro-2-methoxy-N-[2-(4-sulfamoy 16673-34-0 NLRP3i Benzamide, N-[2-[4-(aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxy- NLRP3-IN-2 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide ISO 9001：2015 REACH Glibenclamide EP Impurity A/ Glyburide Related Compound A Glibenclamide EP Impurity AQ: What is Glibenclamide EP Impurity A Q: What is the CAS Number of Glibenclamide EP Impurity A Q: What is the storage condition of Glibenclamide EP Impurity A Q: What are the applications of Glibenclamide EP Impurity A Glibenclamide ImpurityⅠ:5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide Glyburide Related Compound A (4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide) (1295516) Glibenclamide Impurity 7 5-Chloro-2-Methoxy-N-(4-sulfaMoylphenethyl)benzaMide Sulphonamide of Glibenclamide Glibenclamide (Glyburide) EP Impurity A (Glibenclamide (Glyburide) USP Related Compound A) 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide|||NLRP3 Inflammasome Inhibitor I Glibenclamide Impurity Ⅰ(4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide) 16673-34-0 C16H17ClN2O4S ClC6H3OCH3CONHCH2C6H4SO2NH2 C16H17N2O4ClS 36884 Sulfur Compounds