Fenspiride hydrochloride
- CAS No.
- 5053-08-7
- Chemical Name:
- Fenspiride hydrochloride
- Synonyms
- jp428;Erespal;NAT 333;espiran;fluiden;Tegencia;Decaspir;pneumorel;Viarespan;NDR 5998A
- CBNumber:
- CB7295887
- Molecular Formula:
- C15H21ClN2O2
- Molecular Weight:
- 296.8
- MDL Number:
- MFCD00133315
- MOL File:
- 5053-08-7.mol
| Melting point | 235-238°C (dec.) |
|---|---|
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | powder |
| color | white |
| FDA UNII | 832NBX878V |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H332-H312 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RO0375000 | |||||||||
| HS Code | 2934.99.3000 | |||||||||
| Toxicity | LD50 i.v. in mice: 106 mg/kg; orally in rats: 437 mg/kg (LeDouarec) | |||||||||
| NFPA 704 |
|
Fenspiride hydrochloride price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F1211 | Fenspiride Hydrochloride | 5053-08-7 | 1G | $61 | 2024-03-01 | Buy |
| TCI Chemical | F1211 | Fenspiride Hydrochloride | 5053-08-7 | 5G | $171 | 2024-03-01 | Buy |
| Cayman Chemical | 25512 | Fenspiride (hydrochloride) ≥95% | 5053-08-7 | 5g | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 25512 | Fenspiride (hydrochloride) ≥95% | 5053-08-7 | 10g | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 25512 | Fenspiride (hydrochloride) ≥95% | 5053-08-7 | 25g | $216 | 2024-03-01 | Buy |
Fenspiride hydrochloride Chemical Properties,Uses,Production
Pharmacological effects
As an α adrenergic and H1 histamine receptor antagonist, Fenspiride has been shown to be antiinflammatory, anti-allergic and antioxidant. Fenspiride inhibited SO2-induced goblet cell hyperplasia in rats, with concomitant inhibition of increased hexose and fucose, indicative of mucus hypersecretion, in lavage fluid. Fenspiride also exhibits neuronal inhibitory activity. For example, in guinea pigs, it reverses capsaicin-induced and citric acid-induced bronchoconstriction and cough, and inhibits cholinergic and non-adrenergic, non-cholinergic (NANC) neural contraction of isolated bronchi.
Indications
Fenspiride hydrochloride is a bronchodilator, which was used as a drug in the treatment of certain respiratory diseases. Finsecbili hydrochloride against serotonin, dilating bronchial smooth muscle, the intensity of action is between isoproterenol and theophylline, in addition to reducing the resistance of air movement in the lungs, experiments have shown that this product has dilated bronchial smooth muscle, antitussive, antipyretic and analgesic effects. Suitable for chronic bronchitis, bronchial asthma and chronic respiratory insufficiency. In Russia it was approved for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract, as well as for maintenance treatment of asthma (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis).
Chemical Properties
Pale Yellow Solid
Originator
Viarespan,Servier,France,1969
Uses
Antiinflammatory;Bradykinin antagonist
Uses
Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenergic and H1 histamine receptors.
Manufacturing Process
A solution of 192 g of 1-phenethyl-4-hydroxy-4-aminomethyl piperidine in 800
cc of diethylcarbonate is heated for 2? hours to reflux at about 80°C in the
presence of sodium methylate (prepared for immediate use from 2 g of
sodium). After this time, the ethyl alcohol formed during the reaction is slowly
distilled while the maximum temperature is reached. The excess ethyl
carbonate is distilled under reduced pressure. A crystallized residue is then
obtained, which is stirred with 400 cc of water and 400 cc of ether. The
solution is filtered and 125 g (77.6%) of practically pure product melting at
232°C to 233°C, are obtained.
The starting material was prepared in a yield of 58% by reduction of the
corresponding cyanohydrin. It in turn was prepared from 1-(2-phenylethyl)-4-
piperidone and potassium cyanide to give the cyanohydrin which was reduced
by lithium aluminum hydride.
Therapeutic Function
Bronchodilator
Fenspiride hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 | CHINA | 115 | 55 | |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9214 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| Jinan Chenghui-Shuangda Chemical Co.,Ltd | +86-531-58897082 | ericqiao@jnchsd.com | CHINA | 158 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2529 | 58 |
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View Lastest Price from Fenspiride hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Fenspiride hydrochloride
5053-08-7
|
US $30.00-95.00 / mg | 99.78% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Fenspiride hydrochloride
5053-08-7
|
US $30.00-95.00 / mg | 99.78% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-08-18 | Fenspiride hydrochloride
5053-08-7
|
US $1.00 / g | 1g | 99% | 10tons | Hebei Binshare New Material Co. Ltd |
-
- Fenspiride hydrochloride
5053-08-7
- US $30.00-95.00 / mg
- 99.78%
- TargetMol Chemicals Inc.
-
- Fenspiride hydrochloride
5053-08-7
- US $30.00-95.00 / mg
- 99.78%
- TargetMol Chemicals Inc.
-
- Fenspiride hydrochloride
5053-08-7
- US $1.00 / g
- 99%
- Hebei Binshare New Material Co. Ltd
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