ChemicalBook >> CAS DataBase List >>NDI-010976
NDI-010976
- CAS No.
- 1434635-54-7
- Chemical Name:
- NDI-010976
- Synonyms
- ND-630;GS0976;CS-2609;CS-2632;CPDB5078;EOS-61252;NDI-010976;Firsocostat;GS0976,ND-630;ND-630（GS0976）
- CBNumber:
- CB73133386
- Molecular Formula:
- C28H31N3O8S
- Molecular Weight:
- 569.63
- MDL Number:
- MFCD28963986
- MOL File:
- 1434635-54-7.mol
Last updated:2024-11-19 20:33:22
| Boiling point | 779.0±70.0 °C(Predicted) |
|---|---|
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM) Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM) |
| form | A crystalline solid |
| pka | 3.66±0.10(Predicted) |
| color | White to light yellow |
| FDA UNII | XE10NJQ95M |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
NDI-010976 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23961 | ND-630 ≥98% | 1434635-54-7 | 1mg | $364 | 2024-03-01 | Buy |
| Cayman Chemical | 23961 | ND-630 ≥98% | 1434635-54-7 | 5mg | $1181 | 2024-03-01 | Buy |
| AK Scientific | 9222DU | Firsocostat | 1434635-54-7 | 5mg | $1412 | 2021-12-16 | Buy |
| ChemScene | CS-6509 | Firsocostat 99.48% | 1434635-54-7 | 10mg | $450 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005695 | (R)-2-(1-(2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-5-METHYL-6-(OXAZOL-2-YL)-2,4-DIOXO-1,2-DIHYDROTHIENO[2,3-D]PYRIMIDIN-3(4H)-YL)-2-METHYLPROPANOIC ACID 95.00% | 1434635-54-7 | 5MG | $497.67 | 2021-12-16 | Buy |
NDI-010976 Chemical Properties,Uses,Production
Description
ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.
Uses
Firsocostat or ND-630 (CAS# 1434635-54-7) is an inhibitor of acetyl-coA carboxylase and may favorably affect the morbidity and mortality associated with obesity, diabetes, and fatty liver disease from reduced hepatic steatosis, improved insulin sensitivity, and modulation of dyslipidemia.
NDI-010976 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 97)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9639 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
View Lastest Price from NDI-010976 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Firsocostat
1434635-54-7
|
US $88.00-222.00 / mg | 98.46% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-01-14 | NDI-010976
1434635-54-7
|
US $0.00 / KG | 1KG | 97.4% | 100 tons | Honest Joy Holdings Limited
|
|
 |
2019-07-06 | NDI-010976
1434635-54-7
|
US $7.00 / KG | 1KG | 99% | 100kG | Career Henan Chemical Co |
-
- Firsocostat
1434635-54-7
- US $88.00-222.00 / mg
- 98.46%
- TargetMol Chemicals Inc.
-
- NDI-010976
1434635-54-7
- US $0.00 / KG
- 97.4%
- Honest Joy Holdings Limited
-
- NDI-010976
1434635-54-7
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
1434635-54-7(NDI-010976)Related Search:
NDI-010976
(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoicacid
ND-630
(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid
EOS-61252
GS0976
CPDB5078
(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-
GS0976,ND-630
1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid
ND-630,NDI-010976
Firsocostat
Firsocostat(ND-630,GS-0976)
CS-2609
CS-2632
ND 630; ND630;GS-0976;GS 0976;GS0976;FIRSOCOSTAT
Firsocostat (GS-0976,NDI-010976,ND-630)
ND630;FIRSOCOSTAT
Firsocostat (ND-630
Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-
ND-630（GS0976）
Firsocostat (GS-0976)
ND-630|||NDI-010976|||GS-0976
1434635-54-7
API