NHI 2
- CAS No.
- 1269802-97-2
- Chemical Name:
- NHI 2
- Synonyms
- NHI 2;NHI-2 >=98% (HPLC);Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate;1H-Indole-2-carboxylic acid, 1-hydroxy-6-phenyl-4-(trifluoromethyl)-, methyl ester
- CBNumber:
- CB73146340
- Molecular Formula:
- C17H12F3NO3
- Molecular Weight:
- 335.28
- MDL Number:
- MFCD20264847
- MOL File:
- 1269802-97-2.mol
| Boiling point | 495.7±55.0 °C(Predicted) |
|---|---|
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | solid |
| pka | 10?+-.0.58(Predicted) |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
NHI 2 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30201 | NHI 2 | 1269802-97-2 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 30201 | NHI 2 | 1269802-97-2 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 30201 | NHI 2 | 1269802-97-2 | 10mg | $122 | 2024-03-01 | Buy |
| Tocris | 5363 | NHI2 ≥98%(HPLC) | 1269802-97-2 | 10 | $210 | 2021-12-16 | Buy |
| Tocris | 5363 | NHI2 ≥98%(HPLC) | 1269802-97-2 | 50 | $852 | 2021-12-16 | Buy |
NHI 2 Chemical Properties,Uses,Production
Description
NHI 2 is an inhibitor of lactate dehydrogenase A (LDHA; IC50 = 14.7 μM). It is selective for LDHA over LDHB (IC50 = 55.8 μM). It inhibits lactate production in HeLa cells when used at concentrations of 100 and 200 μM. NHI 2 is cytotoxic to HeLa cells (IC50 = 33.4 μM).
storage
Store at +4°C
References
1) Granchi?et al., (2013),?Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (MaI) scaffolds; Org. Biomol. Chem.,?11?6588 2) Maftouh?et al. (2014), Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia; Br. J. Cancer,?110?172 3) Granchi?et al. (2011),?Discovery of N-Hydroxyindole-based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells; J. Med. Chem.,?54?1599 4) Allison?et al. (2014),?Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p-53-independent pathways; Oncogenesis,?3?e102 5) Lea?et al. (2016)?Inhibition of growth by combined treatment with inhibitors of Lactate Dehydrogenase and either Phenformin of Inhibitors of 6-Phosphofructo-2-kinase / Fructose-2,6-bisphosphatase 3; Anticancer Research,?36?1479 [Focus Biomolecules Citation]
NHI 2 Preparation Products And Raw materials
NHI 2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3067 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6755 | 58 |