BRD6688
- CAS No.
- 1404562-17-9
- Chemical Name:
- BRD6688
- Synonyms
- BRD6688;N-[2-Amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide;1-Pyrrolidinecarboxamide, N-[2-amino-5-(4-pyridinyl)phenyl]-
- CBNumber:
- CB73152567
- Molecular Formula:
- C16H18N4O
- Molecular Weight:
- 282.34
- MDL Number:
- MFCD30719257
- MOL File:
- 1404562-17-9.mol
BRD6688 price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 19836 | BRD6688 ≥98% | 1404562-17-9 | 1mg | $54 | 2024-03-01 | Buy |
Cayman Chemical | 19836 | BRD6688 ≥98% | 1404562-17-9 | 5mg | $231 | 2024-03-01 | Buy |
Cayman Chemical | 19836 | BRD6688 ≥98% | 1404562-17-9 | 10mg | $308 | 2024-03-01 | Buy |
AK Scientific | 9710DS | N-(2-Amino-5-pyridin-4-ylphenyl)pyrrolidine-1-carboxamide | 1404562-17-9 | 5mg | $355 | 2021-12-16 | Buy |
ApexBio Technology | C5334 | BRD6688 | 1404562-17-9 | 10mg | $432 | 2021-12-16 | Buy |
BRD6688 Chemical Properties,Uses,Production
Biological Activity
brd6688 is an hdac inhibitor.a few chromatin modifying enzymes have been implicated in the neurobiology of learning and memory, especially, histone deacetylases (hdacs). hdacs are responsible for catalyzing the posttranslational hydrolysis of acetyl groups from the 3-nitrogen of lysine residues of histone and non-histone proteins.
in vitro
brd6688 was found to demonstrate kinetic selectivity for hdac2 against hdac1, an isoform with 95% similarity within the catalytic binding domain. moreover, brd6688 could increase histone acetylation (h4k12 and h3k9) in primary mouse neuronal cultures [1].
in vivo
mouse in-vivo study showed that brd6688 was able to increase the histone acetylation (h4k12 and h3k9) in hippocampal ca1 neurons of ck-p25 mice. moreove, the increased histone acetylation in brain served as a surrogate pharmacodynamic marker of hdac engagement and was consistent with previously observed brain pharmacokinetic properties. in addition, brd6688 rescued the cognitive deficits in ck-p25 mice, a model of neurodegeneration, in a pavlovian fear conditioning behavioral assay [1].
IC 50
21 nm, 100 nm, and 11.48 μm for hdac1, 2, and 3, respectively
References
[1] wagner, f. f.,zhang, y.-l.,fass, d.m., et al. kinetically selective inhibitors of histone deacetylase 2 (hdac2) as cognition enhancers. chem.sci. 6(1), 804-815 (2015).
BRD6688 Preparation Products And Raw materials
Raw materials
Preparation Products
BRD6688 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5225 | 58 |
Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9664 | 60 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4296 | 55 | |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8014 | 62 |
Shanghai TenSus Biotechnology Co., Ltd. | 021-50895067 18616507272 | tensus@163.com | China | 4207 | 58 |