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AMG-3969

AMG-3969 Structure
AMG-3969 structure
CAS No.
1361224-53-4
Chemical Name:
AMG-3969
Synonyms
CS-2503;AMG-3969;AMG-3969, 10 mM in DMSO;AMG-3969; AMG 3969; AMG3969;Hexokinase IV,AMG 3969,Hexokinase D,Glucokinase,Inhibitor,AMG3969,AMG-3969,inhibit;2-[4-[(2S)-4-[(6-amino-3-pyridyl)sulfonyl]-2-prop-1-ynyl-piperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol;Benzenemethanol, 4-[(2S)-4-[(6-amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]-α,α-bis(trifluoromethyl)-;(S)-2-(4-(4-((6-Aminopyridin-3-yl)sulfonyl)-2-(prop-1-yn-1-yl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
CBNumber:
CB73166063
Molecular Formula:
C21H20F6N4O3S
Molecular Weight:
522.46
MDL Number:
MFCD28386194
MOL File:
1361224-53-4.mol
Last updated:2025-04-17 18:22:24
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AMG-3969 Properties

Boiling point 648.8±65.0 °C(Predicted)
Density 1.56±0.1 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility DMSO:100.0(Max Conc. mg/mL);191.4(Max Conc. mM)
pka 10.12±0.15(Predicted)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2935909099

AMG-3969 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-6243 AMG-3969 99.74% 1361224-53-4 5mg $420 2021-12-16 Buy
Apolloscientific BISN0048 AMG-3969 99% 1361224-53-4 5mg $522 2021-12-16 Buy
ChemScene CS-6243 AMG-3969 99.74% 1361224-53-4 10mg $600 2021-12-16 Buy
Apolloscientific BISN0048 AMG-3969 99% 1361224-53-4 10mg $747 2021-12-16 Buy
ChemScene CS-6243 AMG-3969 99.74% 1361224-53-4 1mg $180 2021-12-16 Buy
Product number Packaging Price Buy
CS-6243 5mg $420 Buy
BISN0048 5mg $522 Buy
CS-6243 10mg $600 Buy
BISN0048 10mg $747 Buy
CS-6243 1mg $180 Buy

AMG-3969 Chemical Properties,Uses,Production

Description

AMG-3969is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor. Itcan strongly boost the dissociation of the GK-GKRP complex and promote GK translocation in-vivo. In rodent model of diabetes, AMG-3969 reduces blood glucose levels without affecting euglycemic animals. It is a promising drug for the treatment of type II diabetes through lowering blood glucose levels with reduced potential for hypoglycaemic risk.

Uses

AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM.

in vivo

AMG-3969 has good in vivo pharmacokinetic (PK) properties in rats (75%) and significantly lowers blood glucose levels in a dose-dependent manner db/db mice[1]. AMG-3969 (100 mg/kg) demonstrates significant reductions in blood glucose with robust efficacy (56% reduction) observed at the 8 h time point[2]. AMG-3969 demonstrates dose-dependent efficacy in three models of diabetes: diet induced obese (DIO), ob/ob and db/db mice; however,AMG-3969 is ineffective in lowering blood glucose in normoglycaemic C57BL/6 (B6) mice. AMG-3969 is highly effective in promoting carbohydrate substrate. AMG-3969 exhibits extended changes to carbohydrate oxidation as observed by increased respiratory exchange ratio into the next night and day after a single dose[3].

References

Lloyd, David J., et al. "Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors." Nature 504.7480(2013):437-40.
Bourbeau, M. P., et al. "Nonracemic synthesis of GK-GKRP disruptor AMG-3969. " Synfacts 79.8(2014):3684.
http://www.metonchem.com/products/amg-3969-cas1361224-53-4/

AMG-3969 Preparation Products And Raw materials

Raw materials

Preparation Products

AMG-3969 Suppliers

Global( 71)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39003 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58

View Lastest Price from AMG-3969 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AMG-3969 pictures 2025-04-27 AMG-3969
1361224-53-4
 US $123.00-388.00 / mg 99.65% 10g TargetMol Chemicals Inc.
  • AMG-3969 pictures
  • AMG-3969
    1361224-53-4
  • US $123.00-388.00 / mg
  • 99.65%
  • TargetMol Chemicals Inc.
AMG-3969 CS-2503 AMG-3969; AMG 3969; AMG3969 Benzenemethanol, 4-[(2S)-4-[(6-amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]-α,α-bis(trifluoromethyl)- (S)-2-(4-(4-((6-Aminopyridin-3-yl)sulfonyl)-2-(prop-1-yn-1-yl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol Hexokinase IV,AMG 3969,Hexokinase D,Glucokinase,Inhibitor,AMG3969,AMG-3969,inhibit 2-[4-[(2S)-4-[(6-amino-3-pyridyl)sulfonyl]-2-prop-1-ynyl-piperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol AMG-3969, 10 mM in DMSO 1361224-53-4 C21H20F6N4O3S