Diphosgene
- CAS No.
- 503-38-8
- Chemical Name:
- Diphosgene
- Synonyms
- DP;TRICHLOROMETHYL CHLOROFORMATE;ASP-PRO;Difosgen;Perstoff;Diphosgen;DIPHOSGENE;Disphosgene;Diphosgene,99%;perchloromethylformate
- CBNumber:
- CB7332155
- Molecular Formula:
- C2Cl4O2
- Molecular Weight:
- 197.83
- MDL Number:
- MFCD00015553
- MOL File:
- 503-38-8.mol
- MSDS File:
- SDS
| Melting point | -57 °C |
|---|---|
| Boiling point | 20 °C10 mm Hg(lit.) |
| Density | 1.64 |
| refractive index |
n |
| Flash point | >110°C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Soluble), Ethyl Acetate (Sparingly) |
| form | Liquid |
| color | Clear colorless |
| Water Solubility | may decompose |
| Sensitive | Moisture Sensitive |
| Merck | 14,3334 |
| BRN | 970225 |
| Stability | Hygroscopic, Moisture Sensitive |
| CAS DataBase Reference | 503-38-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | PO4Q4R80LV |
| NIST Chemistry Reference | Trichloromethyl chloroformate(503-38-8) |
| EPA Substance Registry System | Carbonochloridic acid, trichloromethyl ester (503-38-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H314-H330 |
| Precautionary statements | P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | T+,Xi |
| Risk Statements | 26/28-34-26/27/28-36/37/38 |
| Safety Statements | 26-28-36/37/39-45-28A-36 |
| RIDADR | UN 3277 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | LQ7350000 |
| F | 8-10-19 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29159000 |
| Toxicity | LC100 in rabbits (10-20 minutes exposure to vapor): 0.9 mg/l air (Klika, Mysliveckova) |
Diphosgene price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 23261 | Trichloromethyl chloroformate ≥97.0% (GC) | 503-38-8 | 10ml | $135 | 2024-03-01 | Buy |
| Sigma-Aldrich | 23261 | Trichloromethyl chloroformate ≥97.0% (GC) | 503-38-8 | 50ml | $625 | 2024-03-01 | Buy |
| Alfa Aesar | A17444 | Trichloromethyl chloroformate, 98% | 503-38-8 | 10g | $53.65 | 2024-03-01 | Buy |
| Alfa Aesar | A17444 | Trichloromethyl chloroformate, 98% | 503-38-8 | 50g | $229 | 2024-03-01 | Buy |
| Alfa Aesar | A17444 | Trichloromethyl chloroformate, 98% | 503-38-8 | 250g | $778 | 2024-03-01 | Buy |
Diphosgene Chemical Properties,Uses,Production
Description
Diphosgene (DP), trichloromethyl chloroformate, is a clear, colorless liquid with an odor similar to phosgene. It is noncombustible, a strong irritant to the eyes and tissues, and is toxic by inhalation and ingestion. DP has a boiling point of 127°C–128°C (263°F) and a vapor pressure of 4.2 at 68°F (20°C). The liquid density is 1.65, which is heavier than water, and a melting/freezing point of 314°F (157°C). Inhalation LC50 is 3600 mg/m3 for 10 min. Effects of exposure are quite similar to phosgene gas. Its molecular formula is ClCOOCCl3, and the structure and molecular formula are shown in Figure 8.38. The DOT lists diphosgene as a 6.1 poison liquid. The NFPA 704 designation for CG is estimated to be health 4, flammability 0, reactivity 1, and special 0. It has a four-digit UN identification number of 2972.
Chemical Properties
clear colorless liquid
Uses
Reactant for preparation of:
- Cyclic carbamimidates using a monophosphine gold(i) catalyst
- N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands
- Prostate-specific membrane antigen-targeted anticancer prodrugs
- Potential west nile virus protease inhibitors
- Antibody-drug conjugates (ADCs)
- Erythromycin A derivatives
Uses
Trichloromethyl chloroformate is used as a reagent in the synthesis of organic compounds. It serves as a source of phosgene used in some laboratory preparations. Also, it is used as a reactant for the synthesis of cyclic carbamimidates, N-alkenyl and cycloalkyl carbamates and prostate-specific membrane antigen-targeted anticancer prodrugs. In addition, it is involved in the preparation of an erythromycin A derivatives and antibody-drug conjugates. It is utilized in the conversion of amines, carboxylic acids, formamides in to isocyanates, acid chlorides and isocyanides respectively.
Uses
In organic synthesis; as war gas.
Definition
diphosgene: A colourless liquid,ClCO.O.CCl3, originally used in 1916by Germany in World War I as achemical warfare agent. It is nowused as a reagent in organic synthesis.See also carbonyl chloride.
General Description
Colorless liquid, odorless to fruity.
Air & Water Reactions
Decomposes slowly in water or moist air (or when inhaled) to form very corrosive hydrogen chloride gas (hydrochloric acid) and carbon monoxide.
Hazard
Toxic by inhalation and ingestion, strong irritant to tissue.
Fire Hazard
Some may burn but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.
Safety Profile
Low toxicity by inhalation. A corrosive liquid. When heated to decomposition it emits toxic vapors of Cl-.
Diphosgene Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29882 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | +8615377521700 | wangwendy93@gmail.com | China | 868 | 58 |
| Shanghai Yudiao Chemistry Technology Co.,Ltd | 02137285211 18964703211 | info@yudiaochem.com | CHINA | 238 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34553 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 | sales1@gotopbio.com | CHINA | 2609 | 58 |
View Lastest Price from Diphosgene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-16 | DP | US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | |
 |
2019-07-06 | Diphosgene
503-38-8
|
US $1.00 / kg | 1kg | 99% | 100KG | Career Henan Chemical Co |
-
- DP
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
-
- Diphosgene
503-38-8
- US $1.00 / kg
- 99%
- Career Henan Chemical Co
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