ChemicalBook >> CAS DataBase List >>Tubulysin B
Tubulysin B
- CAS No.
- 205304-87-6
- Chemical Name:
- Tubulysin B
- Synonyms
- Tubulysin B;(2S,4R)-4-({2-[(1R,3R)-1-(acetyloxy)-3-[(2S,3S)-N-[(butanoyloxy)methyl]-3-methyl-2-{[(2R)-1-methylpiperidin-2-yl]formamido}pentanamido]-4-methylpentyl]-1,3-thiazol-4-yl}formamido)-5-(4-hydroxyphenyl)-2-methylpentanoic acid;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
- CBNumber:
- CB73339922
- Molecular Formula:
- C42H63N5O10S
- Molecular Weight:
- 830.05
- MDL Number:
- MFCD29477701
- MOL File:
- 205304-87-6.mol
Last updated:2024-11-04 08:52:07
| Boiling point | 978.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.204±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 4.52±0.23(Predicted) |
| color | White to off-white |
| InChIKey | HWCIETDQUHYHGQ-OSGLCLOFNA-N |
| FDA UNII | 44D2D2M50T |
Tubulysin B price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| DC Chemicals | DC11284 | TubulysinB >98% | 205304-87-6 | 1mg | $1200 | 2021-12-16 | Buy |
| DC Chemicals | DC11284 | TubulysinB >98% | 205304-87-6 | 5mg | $3600 | 2021-12-16 | Buy |
| DC Chemicals | DC11284 | TubulysinB >98% | 205304-87-6 | 10mg | $6500 | 2021-12-16 | Buy |
Tubulysin B Chemical Properties,Uses,Production
Description
Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agent isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug-resistant properties. It is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.
Definition
ChEBI: Tubulysin B is a butyrate ester.
in vitro
Tubulysin B has IC50s of 0.6 and 0.9 nM against KB and A549 tumors cell lines, respectively.
Tubulysin B Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 15)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accendatech Co., Ltd. | +8613132578992 | yunhao.liu@accendatech.com | China | 251 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4589 | 55 | |
| Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3254 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1990 | 58 |
| Tianjin Shangde Medicine Edge Technology Co., Ltd | 13370460931 | sales@accendatech.com | China | 11 | 58 |
| Hangzhou FuRun Pharmaceutical Technology Co., Ltd | 15658004993 | 1900830611@qq.com | China | 965 | 58 |
Tubulysin B
Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
(2S,4R)-4-({2-[(1R,3R)-1-(acetyloxy)-3-[(2S,3S)-N-[(butanoyloxy)methyl]-3-methyl-2-{[(2R)-1-methylpiperidin-2-yl]formamido}pentanamido]-4-methylpentyl]-1,3-thiazol-4-yl}formamido)-5-(4-hydroxyphenyl)-2-methylpentanoic acid
205304-87-6
C42H63N5O10S