5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
- CAS No.
- 1189987-23-2
- Chemical Name:
- 5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
- Synonyms
- 5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide;Leflunomide-d4Q: What is Leflunomide-d4 Q: What is the CAS Number of Leflunomide-d4 Q: What is the storage condition of Leflunomide-d4 Q: What are the applications of Leflunomide-d4
- CBNumber:
- CB73595607
- Molecular Formula:
- C12H9F3N2O2
- Molecular Weight:
- 270.21
- MDL Number:
- MFCD06658907
- MOL File:
- 1189987-23-2.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302+H312+H332-H315-H319 | |||||||||
Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501 | |||||||||
NFPA 704 |
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5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 26448 | Leflunomide-d4 | 1189987-23-2 | 500μg | $139 | 2024-03-01 | Buy |
Cayman Chemical | 26448 | Leflunomide-d4 | 1189987-23-2 | 1mg | $278 | 2024-03-01 | Buy |
TRC | L322752 | Leflunomide-d4 | 1189987-23-2 | 10mg | $1110 | 2021-12-16 | Buy |
AK Scientific | 5550DF | Leflunomide-d4 | 1189987-23-2 | 1mg | $441 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | D3769 | Leflunomide-d4 | 1189987-23-2 | 0.01g | $840 | 2021-12-16 | Buy |
5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide Chemical Properties,Uses,Production
Uses
An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases.This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.
Biological Activity
Leflunomide-d4 is intended for use as an internal standard for the quantification of leflunomide by GC- or LC-MS. Leflunomide is a synthetic isoxazol and a prodrug form of A-771726 , a dihydroorotate dehydrogenase inhibitor.1 Leflunomide inhibits de novo pyrimidine synthesis to regulate T lymphocyte progression through the cell cycle. It inhibits proliferation and activation of T cells when used at concentrations of 25 and 100 μM, respectively, for na?ve and memory CD4+ T cells.2 It also reduces the production of Th1 effector cells and increases differentiation of Th2 cells in vitro and in splenocytes isolated from KLH-immunized mice. Leflunomide (35 mg/kg per day) reduces and prevents inflammation in a proteoglycan-induced mouse model of rheumatoid arthritis.3 Formulations containing leflunomide have been used in the treatment of active rheumatoid arthritis.
References
1.Breedveld, F.C., and Dayer, J.-M.Leflunomide: Mode of action in the treatment of rheumatoid arthritisAnn. Rheum. Dis.59(11)841-849(2000) 2.Dimitrova, P., Skapenko, A., Herrmann, M.L., et al.Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiationJ. Immunol.169(6)3392-3399(2002) 3.Glant, T.T., Mikecz, K., Bartlett, R.R., et al.Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomideImmunopharmacology23(2)105-116(1992)
5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Nanjing Haolv Biotechnology Co.,Ltd | 025-84622273 02584622273; | kexin.zhou@haolvbiotech.com | China | 3022 | 58 |
Hefei Molake Biotechnology Co., Ltd. | 0551-66336380 18956014586 | 983438788@qq.com | China | 2103 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
ChengDu SinoStandards Bio-Tech Co.,Ltd. , | 028-83243028 19136088901 | sinostandards@163.com | China | 5359 | 58 |
Yancheng Tongming Biotechnology Co., Ltd. | 15195160625 | 2863565288@qq.com | China | 5194 | 58 |
Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12584 | 58 |
SHANGHAI ZZBIO CO., LTD. | 19921389125 19921389125 | tech@zzbioco.com | China | 12065 | 58 |