N,O-Bis(trimethylsilyl)acetamide
- CAS No.
- 10416-59-8
- Chemical Name:
- N,O-Bis(trimethylsilyl)acetamide
- Synonyms
- BSA;BIS(TRIMETHYLSILYL)ACETAMIDE;TriMethylsilyl N-(triMethylsilyl)acetiMidate;TMS-BA;dynasylan bsa;bis(trimethylsllyl)acetamide;N.O-Bis(trimethylsilyl)acetamide (BSA);(E)-TriMethylsilyl N-(triMethylsilyl)acetiMidate;trimethylsilyl (1E)-N-trimethylsilylethanimidate;BSiA
- CBNumber:
- CB7366985
- Molecular Formula:
- C8H21NOSi2
- Molecular Weight:
- 203.43
- MDL Number:
- MFCD00008270
- MOL File:
- 10416-59-8.mol
- MSDS File:
- SDS
| Melting point | 24 °C |
|---|---|
| Boiling point | 71-73 °C35 mm Hg(lit.) |
| Density | 0.832 g/mL at 20 °C(lit.) |
| vapor pressure | 10 hPa (50 °C) |
| refractive index |
n |
| Flash point | 53 °F |
| storage temp. | Store below +30°C. |
| solubility | Miscible with many nonpolar and polar aprotic solvents. |
| form | Crystalline Powder, Crystals and/or Chunks |
| pka | 5.82±0.50(Predicted) |
| Specific Gravity | 0.832 |
| color | Light yellow or beige to brown |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 1306669 |
| CAS DataBase Reference | 10416-59-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | R14N49I64O |
| NIST Chemistry Reference | Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8) |
| EPA Substance Registry System | Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester (10416-59-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H302-H314 | |||||||||
| Precautionary statements | P210-P233-P280-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | C,Xn,F | |||||||||
| Risk Statements | 10-14-22-34-40-20/21/22-11 | |||||||||
| Safety Statements | 26-36/37/39-45-7/8-43A-36-30-23-16-7/9 | |||||||||
| RIDADR | UN 2920 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AK3000000 | |||||||||
| F | 10-21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29310095 | |||||||||
| Toxicity | LD50 orally in Rabbit: 1580 mg/kg | |||||||||
| NFPA 704 |
|
N,O-Bis(trimethylsilyl)acetamide price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.18727 | N,O-Bis(trimethylsilyl)acetamide for synthesis | 10416-59-8 | 25mL | $65.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.18727 | N,O-Bis(trimethylsilyl)acetamide for synthesis | 10416-59-8 | 100mL | $180 | 2024-03-01 | Buy |
| Sigma-Aldrich | 128910 | N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% | 10416-59-8 | 10ml | $63.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 128910 | N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% | 10416-59-8 | 1l | $639 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1.09649 | N,O-Bis(trimethylsilyl)acetamide for gas chromatography | 10416-59-8 | 25mL | $200 | 2022-05-15 | Buy |
N,O-Bis(trimethylsilyl)acetamide Chemical Properties,Uses,Production
Description
Clear to yellowish clear liquid liquid which is soluble in many nonpolar and polar aprotic solvents.
The trimethylsilyl group is a frequently utilized monofunctional blocking group for protic organic and inorganic materials. As it eliminated during the silylation is neutral acetamide, N,O-Bis(trimethylsilyl)acetamide can be preferably used for substrates which are acid- or base-sensitive.
N,O-bis(trimethylsilyl)-acetamide is an effective silylating agent. It is used in the pharmaceutical and in the chemical industry. Typically the silylating reaction with BSA results in neutral by-products only.
Uses
- Used for blocking and protection of hydroxyl groups in natural products, e.g. amino acids, carbohydrates;
- Used for blocking and protection of functional groups in organic intermediates;
- Used for formation of derivatives of H-acid compounds for analysis;
Physical properties
bp 71–73°C/35 mmHg.
Uses
N,O-bis(trimethylsilyl)-acetamide (BSA) is frequently used with TMCS as a catalyst to modify a variety of functional groups including carboxyl groups. In one novel application, BSA was used to measure carboxypeptidase activity by forming derivatives which could be determined by gas chromatography.BSA has been used to prepare derivatives of steroids and glucocorticoids.
Uses
Powerful silylation reagent for a wide range of functional groups under mild conditions
Uses
N,O-Bis(trimethylsilyl)acetamide is a powerful silylating agent; reacts with a wide range of functional
groups.
BSA was used to
trimethylsilylate the hydroxyl group of 12 selectively to form
in almost quantitative yield (eq 32).The presence of catalytic
amounts (～0.02 equiv) of tetrabutylammonium fluoride (TBAF)
significantly promoted the silylation of alcohols under mild conditions
with high chemoselectivity, i.e., TBAF plays a role as a
smooth silyl transfer catalyst from nitrogen to the hydroxyl group.
Preparation
made by the reaction of acetamide with a large excess of chlorotrimethylsilane in the presence of triethylamine.
General Description
N,O-Bis(trimethylsilyl)acetamide is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions.
Purification Methods
Fractionate it through a spinning band column and collect liquid b 71-73o/35mm, and not higher because the main impurity MeCONHSiMe3 distils at b 105-107o/35mm. It is used for derivatising alcohols and sugars [Klebe et al. J Am Chem Soc 88 3390 1966, see Matsuo et al. Carbohydr Res 241 209 1993, Johnson Carbohydr Res 237 313 1992]. Itis FLAMMABLE and TOXIC.
N,O-Bis(trimethylsilyl)acetamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Medfine Bio-pharmaceutical Co., Ltd | +8619921460217 | tina.lv@bio-medfine.com | China | 287 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12840 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18154 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20287 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18779 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
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- N, O-Bis(trimethylsilyl)acetamide (BSA) is a colourless liquid with a 71–73 °C/35 mmHg boiling point. It is extremely moisture....
- Sep 18，2024
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View Lastest Price from N,O-Bis(trimethylsilyl)acetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-21 | N,O-Bis(trimethylsilyl)acetamide
10416-59-8
|
US $1.00 / KG | 1KG | ≥99% | 2000mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2024-10-30 | N,O-Bis(trimethylsilyl)acetamide
10416-59-8
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-10-25 | N,O-Bis(trimethylsilyl)acetamide
10416-59-8
|
US $40.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- N,O-Bis(trimethylsilyl)acetamide
10416-59-8
- US $1.00 / KG
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- N,O-Bis(trimethylsilyl)acetamide
10416-59-8
- US $0.00-0.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- N,O-Bis(trimethylsilyl)acetamide
10416-59-8
- US $40.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
10416-59-8(N,O-Bis(trimethylsilyl)acetamide)Related Search:
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