Anti - P Glycoprotein antibodies
- CAS No.
- Chemical Name:
- Anti - P Glycoprotein antibodies
- Synonyms
- ANTI-PGP;ANTI-MDR;Anti-CLCS;Anti-PGY1;Anti-ABC20;Anti-CD243;Anti-GP170;ANTI-MDR 1;ANTI-ABCB1;Anti-KIAA0882
- CBNumber:
- CB7372056
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00282355
- MOL File:
- Mol file
Anti - P Glycoprotein antibodies price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P7965 | Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse clone F4, ascites fluid | 0.2mL | $250.8 | 2024-03-01 | Buy | |
| Sigma-Aldrich | P7965 | Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse clone F4, ascites fluid | 100μL | $485 | 2024-03-01 | Buy | |
| Sigma-Aldrich | HPA074614 | Anti-ABCB1 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 100μL | $514 | 2024-03-01 | Buy | |
| Sigma-Aldrich | HPA002199 | Anti-ABCB1 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 100μL | $514 | 2024-03-01 | Buy | |
| Sigma-Aldrich | HPA074614 | Anti-ABCB1 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 25μL | $282 | 2023-06-20 | Buy |
Anti - P Glycoprotein antibodies Chemical Properties,Uses,Production
Uses
Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse has been used in western blot analysis and Immunohistochemistry.
General Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. (provided by RefSeq)
Biochem/physiol Actions
Overexpression of ABCB1 (ATP binding cassette subfamily B member 1) gene is a major cause for multi-drug resistance, which makes chemotherapy challenging for the treatment of osteosarcoma. P-glycoprotein (P-gp) mediates the energy-dependent efflux of xenobiotic to the outside of plasma membrane from the inside of the cell , thereby affecting the process of absorption, distribution, and excretion of drugs. Cyclosporine, a calcineurin inhibitor serves as a substrate for P-gp.
Anti - P Glycoprotein antibodies Preparation Products And Raw materials
Raw materials
Preparation Products
Anti - P Glycoprotein antibodies Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |