2-IMINOTHIOLANE
- CAS No.
- 4781-83-3
- Chemical Name:
- 2-IMINOTHIOLANE
- Synonyms
- 2-IMINOTHIOLANE HYDROCHLORIDE;TRAUT'S REAGENT;Nsc340007;2-Iminothiolane ,98%;dihydrothiophen-2(3H)-iMine;2-IMINOTHIOLANE;thiolan-2-iMine;2-IMINOTHIOLANE HCL;IMinothiolane hydrochlorid;2-THIOLANIMINE HYDROCHLORIDE
- CBNumber:
- CB7373482
- Molecular Formula:
- C4H7NS.ClH
- Molecular Weight:
- 137.63
- MDL Number:
- MFCD00039013
- MOL File:
- 4781-83-3.mol
| Melting point | 198-201 °C(lit.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 100 mg/mL |
| form | powder |
| color | White to Off-White |
| Water Solubility | Freely soluble in water |
| BRN | 3620079 |
| CAS DataBase Reference | 4781-83-3(CAS DataBase Reference) |
| FDA UNII | W688HZV733 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 1-3-10 |
| HS Code | 29349990 |
2-IMINOTHIOLANE price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I6256 | 2-Iminothiolane hydrochloride ≥98% (TLC), powder | 4781-83-3 | 100mg | $68.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | I6256 | 2-Iminothiolane hydrochloride ≥98% (TLC), powder | 4781-83-3 | 1g | $212.8 | 2024-03-01 | Buy |
| Alfa Aesar | J60131 | 2-Iminothiolane hydrochloride | 4781-83-3 | 250mg | $178 | 2024-03-01 | Buy |
| Alfa Aesar | J60131 | 2-Iminothiolane hydrochloride | 4781-83-3 | 1g | $267 | 2024-03-01 | Buy |
| Sigma-Aldrich | I6256 | 2-Iminothiolane hydrochloride ≥98% (TLC), powder | 4781-83-3 | 500mg | $256 | 2024-03-01 | Buy |
2-IMINOTHIOLANE Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Uses
2-Iminothiolane hydrochloride is predominantly used as an amine reactive at pH 7-10 and is also an effective thiolation reagent for polysaccharides. It is also used as a RNA-protein crosslinking reagent as well as useful in cross-linking proteins..
Uses
Cross-linking reagent cleavable by thiols.
Uses
2-Iminothiolane hydrochloride is a valuable tool in studies of cellular organelles and oligomeric enzymes, using the techniques of protein-protein cross-linking. It may also be used to introduce reactive sulfhydryl groups into proteins for subsequent reaction with alkylating agents or heavy metal compounds.
General Description
2-Iminothiolane hydrochloride (2-IT.HCl), a protein modification reagent, is commonly employed to attach thiol groups to proteins and peptides. Raman spectroscopic analysis of hair keratin fibers modified with 2-IT.HCl showed the formation of new disulfide groups.
Purification Methods
Recrystallise the hydrochloride from MeOH/Et2O (m 187-192o) or (MeOH/Me2CO), but after sublimation at ~180o/0.2mm the melting point rises to 202-203o. It has 1HNMR with 2.27 (2H, t), 3.25 (2H, t) and 3.52 (2H, t) in (CD3)2SO. [King et al. Biochemistry 17 1499 1978.] The free base is purifed by vacuum distillation (b 71-72o/6mm) with IR (film) with 1700 (C=N)cm-1 and 1HNMR (CDCl3) with at 3.58 (2H, t) and max 2.10-2.8 (4H, m). The free base is stable on storage but slowly hydrolyses in aqueous solutions with half-lives at 25o of 390hours at pH 9.1, 210hours at pH 10 and 18hours at pH 11. [Traut et al. Biochemistry 12 3266 1973, Biochemistry 17 399 1978, Alagon & King Biochemistry 19 4343 1980, Beilstein 17/9 V 12.]
2-IMINOTHIOLANE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3002 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| Henan Alfa Chemical Co., Ltd | China | 13225 | 58 | ||
| VladaChem GmbH | +49-7246-3082843 | info@vladachem.de | Germany | 1859 | 58 |
| PT CHEM GROUP LIMITED | peter68@ptchemgroup.com | China | 35425 | 58 |
View Lastest Price from 2-IMINOTHIOLANE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 2-Iminothiolane HCl
4781-83-3
|
US $48.00-41.00 / mg | ≥98% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-07-18 | 2-Iminothiolane hydrochloride
4781-83-3
|
US $1.00-22.00 / KG | 1KG | 99% | 100000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- 2-Iminothiolane HCl
4781-83-3
- US $48.00-41.00 / mg
- ≥98%
- TargetMol Chemicals Inc.
-
- 2-Iminothiolane hydrochloride
4781-83-3
- US $1.00-22.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd