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(-)-Viriditoxin

CAS No.
1381782-08-6
Chemical Name:
(-)-Viriditoxin
Synonyms
(-)-Viriditoxin;(?)-Viriditoxin;[6,6'-Bi-1H-naphtho[2,3-c]pyran]-3,3'-diacetic acid, 3,3',4,4'-tetrahydro-9,9',10,10'-tetrahydroxy-7,7'-dimethoxy-1,1'-dioxo-, 3,3'-dimethyl ester, (3S,3'S,6R)-
CBNumber:
CB73950277
Molecular Formula:
C34H30O14
Molecular Weight:
662.59
MDL Number:
MOL File:
1381782-08-6.mol
Last updated:2023-06-08 09:03:09

(-)-Viriditoxin Properties

Boiling point 904.6±65.0 °C(Predicted)
Density 1.477±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: soluble; Ethanol: soluble
form A solid
pka 3.89±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P330-P305+P351+P338-P337+P313-P501
NFPA 704
0
2 0

(-)-Viriditoxin price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 26601 (−)-Viriditoxin 1381782-08-6 500μg $158 2024-03-01 Buy
Adipogen Life Sciences AG-CN2-0471-C500 (-)-Viriditoxin ≥98%(HPLC) 1381782-08-6 500μg $130 2021-12-16 Buy
Product number Packaging Price Buy
26601 500μg $158 Buy
AG-CN2-0471-C500 500μg $130 Buy

(-)-Viriditoxin Chemical Properties,Uses,Production

Description

(−)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans that has antibacterial and antiproliferative activity. It is active against methicillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 μg/ml). (−)-Viriditoxin is also active against fish pathogens, including S. iniae and S. parauberis (MICs = 0.16-0.21 μg/ml). It inhibits polymerization and the GTPase activity of E. coli FtsZ, a tubulin-like GTPase involved in bacterial cell division (IC50s = 8.2 and 7 μg/ml, respectively). (−)-Viriditoxin inhibits proliferation of human DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5.36, 0.63, and 7.6 μM, respectively) . It is also toxic to mice (LD50 = 2.8 mg/kg, i.p.).

Definition

ChEBI: (M)-viriditoxin is a dimethyl 2,2'-(9,9',10,10'-tetrahydroxy-7,7'-dimethoxy-1,1'-dioxo-3,3',4,4'-tetrahydro-[6,6'-binaphtho[2,3-c]pyran]-3,3'-diyl)diacetate in which the the 3 and 3' positions (bearing the 2-methoxy-2-oxoethyl (CH2CO2Me) groups) both have S configuration, while the 6 and 6' positions (where the binaphthopyran units are linked) have Ra configuration (the M atropisomer). It has been isolated from the fungi Aspergillus viridinutans and the fungus Paecilomyces variotii derived from the inner tissues of the giant jellyfish Nemopilema nomurai. It has a role as a mycotoxin, an Aspergillus metabolite and an antibacterial agent. It is functionally related to a semiviriditoxin.

(-)-Viriditoxin Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-Viriditoxin Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14059 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9707 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 28118 58
[6,6'-Bi-1H-naphtho[2,3-c]pyran]-3,3'-diacetic acid, 3,3',4,4'-tetrahydro-9,9',10,10'-tetrahydroxy-7,7'-dimethoxy-1,1'-dioxo-, 3,3'-dimethyl ester, (3S,3'S,6R)- (?)-Viriditoxin (-)-Viriditoxin 1381782-08-6 C34H30O14