ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate
- CAS No.
- 371924-24-2
- Chemical Name:
- ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate
- Synonyms
- Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate;ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate;3-Quinolinecarboxylic acid, 4-[[4-(diethylamino)phenyl]amino]-6-methyl-, ethyl ester;C2C12,Inhibitor,mitochondrial,MCU-i-4,Mitochondrial Metabolism,MCU-i4,MCUi4,Ca2+,uptake,inhibit,MCU i4,myoblast
- CBNumber:
- CB74119266
- Molecular Formula:
- C23H27N3O2
- Molecular Weight:
- 377.48
- MDL Number:
- MFCD02730422
- MOL File:
- 371924-24-2.mol
| Boiling point | 513.1±50.0 °C(Predicted) |
|---|---|
| Density | 1.163±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility |
DMSO:18.87(Max Conc. mg/mL);50.0(Max Conc. mM) Ethanol:37.75(Max Conc. mg/mL);100.0(Max Conc. mM) |
| form | Solid |
| pka | 7.21±0.44(Predicted) |
| color | White to yellow |
ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0159538 | MCU-i4 | 371924-24-2 | 10mg | $70 | 2021-12-16 | Buy |
| ChemScene | CS-0159538 | MCU-i4 | 371924-24-2 | 25mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0159538 | MCU-i4 | 371924-24-2 | 50mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0159538 | MCU-i4 | 371924-24-2 | 100mg | $400 | 2021-12-16 | Buy |
| Ambeed | A1445645 | Ethyl4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate 98+% | 371924-24-2 | 250mg | $549 | 2021-12-16 | Buy |
ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Chemical Properties,Uses,Production
Biological Activity
MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2]. MCU-i4 modulates mitochondrial Ca2+ uptake to 1 min of incubation, i.e., exerting a negative modulation, indicating that the primary effect of these compounds is a sudden and direct modulation of MCU complex activity[1].MCU-i4 exerted a negative effect on δψ. MCU-i4 has no effect on cell viability[1]. Cell Differentiation Assay[1] Cell Line: Growing medium of 90% confluent C2C12 myoblasts.
storage
Store at -20°C
References
[1]. Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. [2]. Alessandro Rimessi, et al. Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Front Pharmacol. 2021 Mar 11;12:581645.
ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | chaolaichem@foxmail.com | China | 8971 | 58 |
| Wuhan Shanhai Zhihe Biotechnology Co., Ltd. | 17771424646 | shoubull@126.com | China | 962 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3465 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8005 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2976 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9909 | 58 |