ZOTEPINE
- CAS No.
- 26615-21-4
- Chemical Name:
- ZOTEPINE
- Synonyms
- Setous;lodopin;zotepina;ZOTEPINE;Majorpin;Etoxazole Impurity 9;8-Chloro-10-[2-(dimethylamino)ethoxy]dibenzo[b,f]thiepin;f)thiepin,2-chloro-11-(2-(dimethylamino)ethoxy)-dibenzo(;2-chloro-11-(2-dimethylaminoethoxy)-dibenzo(b,f)thiepine;2-chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin
- CBNumber:
- CB7461848
- Molecular Formula:
- C18H18ClNOS
- Molecular Weight:
- 331.86
- MDL Number:
- MFCD00868143
- MOL File:
- 26615-21-4.mol
| Melting point | 90-91° |
|---|---|
| Boiling point | 478.4±45.0 °C(Predicted) |
| Density | 1.0675 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | Store at RT |
| solubility | DMSO: ≥20mg/mL |
| pka | 8.72±0.28(Predicted) |
| form | powder |
| color | white to off-white |
| FDA UNII | U29O83JAZW |
| ATC code | N05AX11 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P310-P391-P405 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-50/53 | |||||||||
| Safety Statements | 45-60-61 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| Toxicity | LD50 in male mice, rats (mg/kg): 108, 458 orally; 43.3, 39.7 i.v.; 40.0, 97.0 i.p.; 84.9, 2080 s.c. (Fukuhara) | |||||||||
| NFPA 704 |
|
ZOTEPINE price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Z0877 | Zotepine >98% (HPLC) | 26615-21-4 | 10mg | $88.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | Z0877 | Zotepine >98% (HPLC) | 26615-21-4 | 50mg | $269 | 2024-03-01 | Buy |
| Cayman Chemical | 23909 | Zotepine ≥98% | 26615-21-4 | 10mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 23909 | Zotepine ≥98% | 26615-21-4 | 25mg | $142 | 2024-03-01 | Buy |
| Cayman Chemical | 23909 | Zotepine ≥98% | 26615-21-4 | 50mg | $270 | 2024-03-01 | Buy |
ZOTEPINE Chemical Properties,Uses,Production
Chemical Properties
White to off white crystalline powder
Originator
Lodopin,Fujisawa Pharmaceutical,Japan,1982
Uses
antipsychotic;Dopamine D2/serotonin 5-HT2 antagonist
Definition
ChEBI: Zotepine is a dibenzothiepine and a tertiary amino compound. It has a role as an alpha-adrenergic drug, a serotonergic drug and a second generation antipsychotic.
Manufacturing Process
A suspension of 30 g of sodium hydride in benzene (30 ml) was added dropwise to 52 g of 8-chlorodibenzo[b,f]thiepin-10(11H)-one dissolved in dimethylformamide (800 ml), and the mixture was heated at 100°C for 2 hours. To this, there were added 68 g of 2-dimethylaminoethyl chloride, and the mixture was heated at 60°C for 39 hours. The reaction mixture, after cooled, was poured into ice-water, and the solution was extracted with ethyl acetate. The ethyl acetate layer, after washed with water, was extracted with 10% hydrochloric acid, when oil was precipitated. The aqueous layer, in which oil was precipitated, was washed with ether, made neutral with concentrated sodium hydroxide solution and then extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over magnesium sulfate, and concentrated to give oil, which was allowed to stand to provide solid. The solid was washed with petroleum ether and recrystallized from cyclohexane to yield 42.5 g of 8-chloro-10-(2-dimethylaminoethyl)-oxydibenzo[b,f]thiepin as crystals, melting point 90°C to 91°C. Maleate as colorless needle, melting point 204°C to 204.5°C.
Therapeutic Function
Tranquilizer
ZOTEPINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| LUYUNJIA CHEMISTRY XIAMEN LIMITED | +86-592-5360779 +86-13055435203 | China | 5988 | 58 |
View Lastest Price from ZOTEPINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Zotepine
26615-21-4
|
US $31.00-106.00 / mg | 99.67% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-04-24 | ZOTEPINE
26615-21-4
|
US $11.00 / kg | 1kg | 99 | 5000 | Jiangsu Bangdeya New Material Technology Co.,Ltd | |
 |
2022-02-18 | ZOTEPINE
26615-21-4
|
US $0.00 / gram | 1gram | 99% | 10kg | Zhejiang J&C Biological Technology Co.,Limited |