N-Acetylpuromycin
- CAS No.
- 22852-13-7
- Chemical Name:
- N-Acetylpuromycin
- Synonyms
- N-Acetylpuromycin;3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine;Adenosine, 3'-[[(2S)-2-(acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-
- CBNumber:
- CB74666508
- Molecular Formula:
- C24H31N7O6
- Molecular Weight:
- 513.55
- MDL Number:
- MFCD30182346
- MOL File:
- 22852-13-7.mol
| Density | 1.47±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 70 mg/ml) or in DMF (up to 55 mg/ml) |
| form | solid |
| pka | 12.98±0.70(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 2 months. |
N-Acetylpuromycin price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25335 | N-Acetylpuromycin ≥98% | 22852-13-7 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 25335 | N-Acetylpuromycin ≥98% | 22852-13-7 | 5mg | $134 | 2024-03-01 | Buy |
| Cayman Chemical | 25335 | N-Acetylpuromycin ≥98% | 22852-13-7 | 10mg | $213 | 2024-03-01 | Buy |
| Cayman Chemical | 25335 | N-Acetylpuromycin ≥98% | 22852-13-7 | 25mg | $442 | 2024-03-01 | Buy |
| Tocris | 5679 | N-Acetylpuromycin ≥98%(HPLC) | 22852-13-7 | 10 | $195 | 2021-12-16 | Buy |
N-Acetylpuromycin Chemical Properties,Uses,Production
Description
N-Acetylpuromycin is a non-ribotoxic form of the antibiotic puromycin that is formed in puromycin-resistant S. alboniger that endogenously express puromycin-acetyltransferase. In AD293(Pr) cells that express puromycin-N-acetyltransferase, the enzyme responsible for the biosynthesis of N-acetylpuromycin, puromycin application induces downregulation of the negative regulators of TGF-β signalling SnoN and Ski without activating MAPK or inhibition of protein synthesis.
Uses
N-Acetylpurinomycin downregulates SnoN and Ski protein expression and promotes TGF-β signaling, independently of MAPK activation.
storage
Store at -20°C
References
1) Hernandez-Damian?et al. (2013),?Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals; Biochim. Biophys. Acta,?1830?5049
N-Acetylpuromycin Preparation Products And Raw materials
Raw materials
Preparation Products
N-Acetylpuromycin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |