ChemicalBook >> CAS DataBase List >>GNE-6640
GNE-6640
- CAS No.
- 2009273-60-1
- Chemical Name:
- GNE-6640
- Synonyms
- GNE-6640;USP7-IN-8;GNE-6776 HCl;Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl-;inhibit,USP7,Inhibitor,USP-7-IN-8,Deubiquitinase,DUBs,USP7IN8,anticancer,USP7 IN 8
- CBNumber:
- CB74667954
- Molecular Formula:
- C21H21N3O2
- Molecular Weight:
- 347.41
- MDL Number:
- MFCD34167533
- MOL File:
- 2009273-60-1.mol
Last updated:2024-07-02 08:55:16
GNE-6640 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0159190 | USP7-IN-8 ≥98.0% | 2009273-60-1 | 5mg | $350 | 2021-12-16 | Buy |
Biorbyt Ltd | orb573139 | GNE-6640 >98% | 2009273-60-1 | 100mg | $1133.9 | 2021-12-16 | Buy |
Biorbyt Ltd | orb573139 | GNE-6640 >98% | 2009273-60-1 | 250mg | $1802 | 2021-12-16 | Buy |
Biorbyt Ltd | orb573139 | GNE-6640 >98% | 2009273-60-1 | 1g | $3655 | 2021-12-16 | Buy |
GNE-6640 Chemical Properties,Uses,Production
Biological Activity
USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1]. USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].
References
[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.
GNE-6640 Preparation Products And Raw materials
Raw materials
Preparation Products
GNE-6640 Suppliers
Global( 13)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 384 | 55 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8017 | 62 |
Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1991 | 58 |
Taizhou Crene Biotechnology Co. Ltd. | 0576-88813233 13396860566 | sales@pharm-intermediates.com | China | 2000 | 58 |
Chunchuang (Wuhan) Technology Co., Ltd | 15342225168 | yutianchun2007@126.com | China | 10007 | 58 |
InvivoChem | 13549236410 | sales@invivochem.cn | China | 6755 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
GNE-6640
Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl-
GNE-6776 HCl
USP7-IN-8
inhibit,USP7,Inhibitor,USP-7-IN-8,Deubiquitinase,DUBs,USP7IN8,anticancer,USP7 IN 8
2009273-60-1