DS-437
- CAS No.
- 1674364-87-4
- Chemical Name:
- DS-437
- Synonyms
- DS-437;DS-437 (DS437;DS-437 >=98% (HPLC);Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-
- CBNumber:
- CB74669958
- Molecular Formula:
- C15H23N7O4S
- Molecular Weight:
- 397.45
- MDL Number:
- MFCD32661891
- MOL File:
- 1674364-87-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301 | |||||||||
Precautionary statements | P301+P330+P331+P310 | |||||||||
RIDADR | UN 2811 6.1 / PGIII | |||||||||
NFPA 704 |
|
DS-437 price More Price(12)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1516 | DS-437 ≥98% (HPLC) | 1674364-87-4 | 5MG | $105 | 2023-06-20 | Buy |
Sigma-Aldrich | SML1516 | DS-437 ≥98% (HPLC) | 1674364-87-4 | 25MG | $424 | 2023-06-20 | Buy |
Cayman Chemical | 29476 | DS-437 | 1674364-87-4 | 1mg | $36 | 2024-03-01 | Buy |
Cayman Chemical | 29476 | DS-437 | 1674364-87-4 | 5mg | $105 | 2024-03-01 | Buy |
Cayman Chemical | 29476 | DS-437 | 1674364-87-4 | 10mg | $188 | 2024-03-01 | Buy |
DS-437 Chemical Properties,Uses,Production
Description
DS-437 is a dual inhibitor of protein arginine methyltransferase 5 (PRMT5) and PRMT7 (IC50s = 5.9 and 6 μM, respectively). It is selective for PRMT5 and PRMT7 over a panel of 29 additional protein, DNA, and RNA methyltransferases at 50 μM, but also inhibits DNMT3A and DNMT3B (IC50s = 52 and 62 μM, respectively). DS-437 (2.5 and 10 μM) inhibits symmetrical arginine dimethylation of FOXP3 in HEK293T cells, as well as symmetrical arginine dimethylation of p60 and the ribonucleoproteins SmD1/D3 and SmB/B’ in MDA-MB-231 cells in a concentration-dependent manner. It inhibits the ability of regulatory T cells (Tregs) to suppress effector T cell (Teff) proliferation in vitro in human and murine Treg suppression assays. DS-437 (10 mg/kg five times per week) reduces tumor growth in a CT26Her2 murine colon cancer model when administered in combination with the anti-p185erbB2/neu antibody 4D5.
Uses
DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells.
Biochem/physiol Actions
DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.
DS-437 Preparation Products And Raw materials
Raw materials
Preparation Products
DS-437 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44844 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
InvivoChem | 13549236410 | sales@invivochem.cn | China | 6755 | 58 |