Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Nav1.7-IN-3

Nav1.7-IN-3

Nav1.7-IN-3 Structure
Nav1.7-IN-3 structure
CAS No.
1788872-06-9
Chemical Name:
Nav1.7-IN-3
Synonyms
Nav1.7-IN-3;Nav-1.7-IN-3,Nav1.7 IN 3,Nav1.7IN3;Benzenesulfonamide, 5-chloro-2-fluoro-4-[[(tetrahydro-1H-pyrrolizin-7a(5H)-yl)methyl]amino]-N-2-thiazolyl-
CBNumber:
CB74845028
Molecular Formula:
C17H20ClFN4O2S2
Molecular Weight:
430.95
MDL Number:
MFCD31813603
MOL File:
1788872-06-9.mol
Last updated:2024-07-02 08:55:17
Request For Quotation

Nav1.7-IN-3 Properties

storage temp. Store at -20°C
solubility DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
form Solid
color White to off-white

Nav1.7-IN-3 Chemical Properties,Uses,Production

Biological Activity

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration[1]. Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes)[1].

References

[1]. Roecker AJ, et al. Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice. Bioorg Med Chem Lett. 2017 May 15;27(10):2087-2093.

Nav1.7-IN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

Nav1.7-IN-3 Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9274 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 025-66061636 18013972705 qqyang@aikonchem.com China 6763 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Fan De(Beijing) Biotechnology Co., Ltd. 58
DC Chemicals 58
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 58
Nav1.7-IN-3 Benzenesulfonamide, 5-chloro-2-fluoro-4-[[(tetrahydro-1H-pyrrolizin-7a(5H)-yl)methyl]amino]-N-2-thiazolyl- Nav-1.7-IN-3,Nav1.7 IN 3,Nav1.7IN3 1788872-06-9 C17H20ClFN4O2S2