4-Aminoantipyrine
- CAS No.
- 83-07-8
- Chemical Name:
- 4-Aminoantipyrine
- Synonyms
- 4-AAP;AMPYRONE;AMINOANTIPYRINE;4-AMINOPHENAZONE;4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one;4-AMINOANTIPYRIN;4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE;4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE;NSC 60242;Minoazophene
- CBNumber:
- CB7485059
- Molecular Formula:
- C11H13N3O
- Molecular Weight:
- 203.24
- MDL Number:
- MFCD00003145
- MOL File:
- 83-07-8.mol
- MSDS File:
- SDS
Melting point | 105-110 °C(lit.) |
---|---|
Boiling point | 340 C |
Density | 0.8 |
refractive index | 1.4930 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | H2O: 0.1 g/mL, clear |
pka | pK1: 4.94(+1) (25°C) |
form | Powder or Crystals |
color | Yellow to yellow-brown |
PH | 7.1 (100g/l, H2O, 20℃)(slurry) |
Odor | Odorless |
Water Solubility | ca. 500 g/L (20 ºC) |
Merck | 14,591 |
BRN | 181635 |
Stability | Stable. May be light sensitive. |
LogP | -0.257 (est) |
CAS DataBase Reference | 83-07-8(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 0M0B7474RA |
NIST Chemistry Reference | Aminoantipyrene(83-07-8) |
EPA Substance Registry System | 4-Aminoantipyrene (83-07-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22-36/37/38-20/21/22 | |||||||||
Safety Statements | 26-36-36/37/39 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | CD2480000 | |||||||||
F | 8-9-23 | |||||||||
Hazard Note | Harmful | |||||||||
TSCA | Yes | |||||||||
HS Code | 29331190 | |||||||||
Toxicity | LD50 orally in Rabbit: 1700 mg/kg | |||||||||
NFPA 704 |
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4-Aminoantipyrine price More Price(58)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 33528 | 4-Aminoantipyrine puriss. p.a., reag. Ph. Eur., ≥99% | 83-07-8 | 25g | $92.5 | 2024-03-01 | Buy |
Sigma-Aldrich | 33528 | 4-Aminoantipyrine puriss. p.a., reag. Ph. Eur., ≥99% | 83-07-8 | 100g | $99.2 | 2024-03-01 | Buy |
Sigma-Aldrich | 1.07293 | 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one GR for analysis | 83-07-8 | 10g | $108 | 2024-03-01 | Buy |
Sigma-Aldrich | 06800 | 4-Aminoantipyrine for spectrophotometric det. of H2O2 and phenols, ≥98.0% | 83-07-8 | 25g | $46.1 | 2024-03-01 | Buy |
Sigma-Aldrich | 1.07293 | 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one GR for analysis | 83-07-8 | 100g | $406 | 2024-03-01 | Buy |
4-Aminoantipyrine Chemical Properties,Uses,Production
Chemical Properties
Amber crystalline powder
Application
4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is also used as indicator for trace phenol determinations in water.
Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample.
Uses
4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties. It readily forms metal complexes due to its amino nitrogen, a strong coordination site.
4-aminoantipyrine forms Schiff bases when treated with aldehydes/ketones, which are used in chemosensing applications.
Coupling Reagent for Trinder's reagent in colorimetric hydrogen peroxide detectionassays.
Forms highly stable dyes by coupling with Trinder's reagent in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.
Preparation
synthesis of 4-aminoantipyrine: Antipyrine is nitrosated by sodium nitrite, reduced by ammonium bisulfite and ammonium sulfite, hydrolyzed by sulfuric acid, and finally neutralized with liquid ammonia to obtain 4-aminoantipyrine.
Definition
ChEBI: 4-aminoantipyrine is a pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antipyretic, a drug metabolite and a marine xenobiotic metabolite. It is a primary amino compound and a pyrazolone. It derives from an antipyrine.
General Description
4-Aminoantipyrine forms heterocyclic Schiff bases, by reaction with various aldehydes and oximes. These Schiff bases form stable complexes with transition metals.
Purification Methods
It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.]
![519-98-2](/CAS/GIF/519-98-2.gif)
![83-07-8](/CAS/GIF/83-07-8.gif)
4-Aminoantipyrine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 973 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
View Lastest Price from 4-Aminoantipyrine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-22 | 4-Aminoantipyrine
83-07-8
|
US $0.00-0.00 / g | 1g | 98.0% | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2024-08-21 | 4-Aminoantipyrine
83-07-8
|
US $60.00 / kg | 1kg | 99% | 1000 | hebei hongtan Biotechnology Co., Ltd | |
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2024-08-20 | 4-Aminoantipyrine
83-07-8
|
US $128.00 / KG | 25KG | 98% | 1-1000kg | Baoji Guokang Bio-Technology Co., Ltd. |
-
- 4-Aminoantipyrine
83-07-8
- US $0.00-0.00 / g
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-Aminoantipyrine
83-07-8
- US $60.00 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
-
- 4-Aminoantipyrine
83-07-8
- US $128.00 / KG
- 98%
- Baoji Guokang Bio-Technology Co., Ltd.