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4-Aminoantipyrine

4-Aminoantipyrine structure

CAS No.: 83-07-8

Chemical Name:: 4-Aminoantipyrine

Synonyms: 4-AAP;AMPYRONE;AMINOANTIPYRINE;4-AMINOPHENAZONE;4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one;4-AMINOANTIPYRIN;4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE;4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE;NSC 60242;Minoazophene

CBNumber:: CB7485059

Molecular Formula:: C11H13N3O

Molecular Weight:: 203.24

MDL Number:: MFCD00003145

MOL File:: 83-07-8.mol

MSDS File:: SDS

Last updated:2024-12-18 14:08:57

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4-Aminoantipyrine Properties

Melting point	105-110 °C(lit.)
Boiling point	340 C
Density	0.8
refractive index	1.4930 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	H₂O: 0.1 g/mL, clear
pka	pK1: 4.94(+1) (25°C)
form	Powder or Crystals
color	Yellow to yellow-brown
PH	7.1 (100g/l, H2O, 20℃)(slurry)
Odor	Odorless
Water Solubility	ca. 500 g/L (20 ºC)
Merck	14,591
BRN	181635
Stability	Stable. May be light sensitive.
LogP	-0.257 (est)
CAS DataBase Reference	83-07-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	0M0B7474RA
NIST Chemistry Reference	Aminoantipyrene(83-07-8)
EPA Substance Registry System	4-Aminoantipyrene (83-07-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Risk Statements

22-36/37/38-20/21/22

Safety Statements

26-36-36/37/39

WGK Germany

RTECS

CD2480000

8-9-23

Hazard Note

Harmful

TSCA

Yes

HS Code

29331190

Toxicity

LD50 orally in Rabbit: 1700 mg/kg

NFPA 704

	1
2		1

4-Aminoantipyrine price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	33528	4-Aminoantipyrine puriss. p.a., reag. Ph. Eur., ≥99%	83-07-8	25g	$92.5	2024-03-01	Buy
Sigma-Aldrich	33528	4-Aminoantipyrine puriss. p.a., reag. Ph. Eur., ≥99%	83-07-8	100g	$99.2	2024-03-01	Buy
Sigma-Aldrich	1.07293	4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one GR for analysis	83-07-8	10g	$108	2024-03-01	Buy
Sigma-Aldrich	06800	4-Aminoantipyrine for spectrophotometric det. of H2O2 and phenols, ≥98.0%	83-07-8	25g	$46.1	2024-03-01	Buy
Sigma-Aldrich	1.07293	4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one GR for analysis	83-07-8	100g	$406	2024-03-01	Buy

Product number	Packaging	Price	Buy
33528	25g	$92.5	Buy
33528	100g	$99.2	Buy
1.07293	10g	$108	Buy
06800	25g	$46.1	Buy
1.07293	100g	$406	Buy

4-Aminoantipyrine Chemical Properties,Uses,Production

Chemical Properties

Amber crystalline powder

Uses

4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties. It readily forms metal complexes due to its amino nitrogen, a strong coordination site.
4-aminoantipyrine forms Schiff bases when treated with aldehydes/ketones, which are used in chemosensing applications.
Coupling Reagent for Trinder's reagent in colorimetric hydrogen peroxide detectionassays.
Forms highly stable dyes by coupling with Trinder's reagent in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.

Application

4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is also used as indicator for trace phenol determinations in water.
Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample.

Definition

ChEBI: 4-aminoantipyrine is a pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antipyretic, a drug metabolite and a marine xenobiotic metabolite. It is a primary amino compound and a pyrazolone. It derives from an antipyrine.

Preparation

synthesis of 4-aminoantipyrine: Antipyrine is nitrosated by sodium nitrite, reduced by ammonium bisulfite and ammonium sulfite, hydrolyzed by sulfuric acid, and finally neutralized with liquid ammonia to obtain 4-aminoantipyrine.

General Description

4-Aminoantipyrine forms heterocyclic Schiff bases, by reaction with various aldehydes and oximes. These Schiff bases form stable complexes with transition metals.

Purification Methods

It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.]

4-Aminoantipyrine synthesis

Synthesis of 4-Aminoantipyrine from 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one

4-Aminoantipyrine Preparation Products And Raw materials

Raw materials

Ammonium bisulfite Iodine solution Sodium nitrite Antipyrine Starch paper

Sulfuric acid 2,3-dimethyl-4-nitroso-1-phenyl-3-pyrazolin-5-one

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Preparation Products

Aminopyrine N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)formamide 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one AMMONIUM ALGINATE Ramifenazone

N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methoxybenzamide 2-CYANO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-ACETAMIDE 3-CHLORO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)PROPANAMIDE AMINOPROPYLON

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4-Aminoantipyrine Suppliers

Global( 420)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12830	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18148	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	970	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18941	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	8771	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29879	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58

Supplier	Advantage
LEAP CHEM CO., LTD.	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hebei Weibang Biotechnology Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from 4-Aminoantipyrine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-01-17	4-Aminoantipyrine 83-07-8	US $0.00-0.00 / g	1g	98.0%	10kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-01-16	4-Aminoantipyrine 83-07-8	US $60.00 / kg	1kg	99%	1000	hebei hongtan Biotechnology Co., Ltd
2025-01-06	4-Aminoantipyrine 83-07-8	US $128.00 / KG	25KG	98%	1-1000kg	Baoji Guokang Bio-Technology Co., Ltd.

4-Aminoantipyrine
83-07-8
US $0.00-0.00 / g
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

4-Aminoantipyrine
83-07-8
US $60.00 / kg
99%
hebei hongtan Biotechnology Co., Ltd

4-Aminoantipyrine
83-07-8
US $128.00 / KG
98%
Baoji Guokang Bio-Technology Co., Ltd.

4-Aminoantipyrine Spectrum

4-Aminoantipyrine(83-07-8)MS 4-Aminoantipyrine(83-07-8)¹HNMR 4-Aminoantipyrine(83-07-8)¹³CNMR 4-Aminoantipyrine(83-07-8)IR1 4-Aminoantipyrine(83-07-8)IR2

83-07-8(4-Aminoantipyrine)Related Search:

Cefazolin sodium salt Cefazolin Chlorodimethylphenylsilane Dimethyl ether Dimethyl fumarate

Dimethyl carbonate N,N-Dimethyl-1,4-phenylenediamine Antipyrine Dimethyl sebacate Dimethyl sulfoxide

Propyphenazone 4,4'-Diaminodiphenylsulfone N,N-Dimethylformamide Acetaminophen Glucosamine

3,4'-DIAMINODIPHENYLMETHANE DIANTIPYRYLMETHANE EC 2.6.1.2

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Metamizole EP Impurity B 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one Metamizole Sodium Impurity 2（Minocycline EP Impurity B） 4-aminoantipirine 4-Amine-2,3-dimethyl-lphenyl-5-pyrazolone-[5],Ampyrone 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on AKOS BBS-00007964 AMINOANTIPYRINE AMINOANTIPYRINE, 4- AMINOANTIPYRINE REAGENT AMINOPHENYZONE AMPYRONE 1-PHENYL-2,3-DIMETHYL-4-AMINOPYRAZOLONE 1,5-DIMETHYL-2-PHENYL-4-AMINOPYRAZOLONE 4-AMINOPHENAZONE 4-AMINOANTIPYRENE 4-AMINOANTIPYRIN 4-AMINOANTIPYRINE 4-AMINOANTIPYRINE REAGENT 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLINE-5-ONE 4-AMINO-1,3-DIMETHYL-2-PHENYL-3-PYRAZOLONE 4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE 4-AMINO-1,5-DIMETHYL-2-PHENYL-3H-PYRAZOL-3-ONE 4-Amino-1,5-dimethyl-2-phenyl-3-pyrazolone 1,5-dimethyl-2-phenyl-4-aminopyrazolin 4-AMINOANTIPYRINE [4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE] 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Ampyrone 1,2-Dihydro-1,5-dimethyl-2-phenyl-4-amino-3H-pyrazol-3-one 1-Phenyl-2,3-dimethyl-4-amino-5-pyrazolone 4-Amino-2,3-dimethyl-1-phenyl-5-pyrazolone 4-Aminoantipyrine [for Biochemical Research] 4-Aminoantipyrine,98% 4-Aminoantipyrine;4-aminophenazone 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYR-AZOL IN-5-ON R. G., REAG. PH. EUR. I 4-AMINOANTIPYRINE FREE BASE 4-AminoantipyrinePuriss 4-AminoantipyrinePuriss(4-Aminophenazone) 4-AMINOBENZENE SULFONIC ACID( Sulphanilic Acid) 4-Amino-1,5-dimethyl-2-phenyl-4-pyrazolin-3-one Aminoantipyrene 4-amino antipyirine 4-AMINOANTIPYRIDINE (AMPYRONE) AMINOANTIPYRINE, 4-(RG) 4-Aminoantipyrine,4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Ampyrone 4-Aminoantipyrine p.a. AMINOANTIPYRINE, 4-(AMPYRONE)(RG) 4-AMINOANTIPYRINERESEARCH GRADE 1,5-Dimethyl-2-phenyl-4-aminopyrazoline 1-Phenyl-2,3-dimethyl-4-aminopyrazloone-[5] 3H-Pyrazol-3-one, 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl- 3-Pyrazolin-5-one, 4-amino-2,3-dimethyl-1-phenyl- 4-AAP 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, 4-Aminophenazone (2,3-Dihydro-1,5-diMethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)aMine Minoazophene NSC 60242 (2,3-Dihydro-1,5-(diMethyl-d3)-3-oxo-2-phenyl-1H-pyrazol- 4-yl)aMine