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Ibipinabant

CAS No.
464213-10-3
Chemical Name:
Ibipinabant
Synonyms
SLV319;BMS 646256;ibipinabant;(S)-SLV 319;Ibipinabant/SLV319/BMS-646256;Ibipinabant Impurity 1 ((S)-SLV 319);(4S)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide;(4S)-3-(4-Chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide;1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-, (4S)-
CBNumber:
CB7504769
Molecular Formula:
C23H20Cl2N4O2S
Molecular Weight:
487.4
MDL Number:
MFCD07370146
MOL File:
464213-10-3.mol
MSDS File:
SDS
Last updated:2023-06-08 09:01:57

Ibipinabant Properties

Density 1.38
storage temp. Store at -20°C
solubility ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form crystalline solid
FDA UNII O5CSC6WH1T

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H335-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
NFPA 704
0
2 0

Ibipinabant price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10009022 (S)-SLV 319 ≥98% 464213-10-3 1mg $81 2024-03-01 Buy
Cayman Chemical 10009022 (S)-SLV 319 ≥98% 464213-10-3 5mg $317 2024-03-01 Buy
Cayman Chemical 10009022 (S)-SLV 319 ≥98% 464213-10-3 10mg $475 2024-03-01 Buy
TRC S560015 (S)-SLV319 464213-10-3 5mg $875 2021-12-16 Buy
TRC S560015 (S)-SLV319 464213-10-3 10mg $1500 2021-12-16 Buy
Product number Packaging Price Buy
10009022 1mg $81 Buy
10009022 5mg $317 Buy
10009022 10mg $475 Buy
S560015 5mg $875 Buy
S560015 10mg $1500 Buy

Ibipinabant Chemical Properties,Uses,Production

Uses

(S)-SLV 319 is a potent, selective CB1 receptor antagonist.

Biological Activity

ki: 7.8 and 7,9 nm for cb1 and peripheral cannabinoid (cb2), respectively(s)-slv 319 is a cb1 receptor antagonist.it has been reported that central cannabinoid (cb1) receptor antagonists may have potential in the treatment of a variety of diseases including cognitive disorders, neuro-inflammatory disorders, obesity, septic shock, psychosis, addiction, as well as gastrointestinal disorders.

in vitro

previous study found that (s)-slv 319 was a potent and selective cb1 receptor antagonist with ki values of 7.8 and 7,9 nm for cb1 and cb2, respectively. in addition, (s)-slv 319 was found to be less lipophilic and thus more water soluble than other previously identified ligands of cb1 receptor [1].

in vivo

previous animal study showed that in rats exposed to an ambient temperature of 22°c, a moderate dose of lps at 25 - 100 μg/kg could induce a fall in body temperature. such response was not affected by desensitization of intra-abdominal trpv1 receptors with resiniferatoxin at 20 μg/kg, by systemic trpv1 antagonism with capsazepine at 40 mg/kg, or by systemic cb2 receptor antagonism with sr144528 at 1.4 mg/kg. in contrast, cb1 receptor antagonism by slv319 at 15 mg/kg or rimonabant at 4.6 mg/kg was able to block lps caused hypothermia [2].

References

[1] j. h. m. lange, h. h. van stuivenberg, w. veerman, et al. novel 3,4-diarylpyrazolines as potent cannabinoid cb1 receptor antagonists with lower lipophilicity. bioorganic & medicinal chemistry letters 15, 4794-4798 (2005).
[2] steiner aa et al. the hypothermic response to bacterial lipopolysaccharide critically depends on brain cb1, but not cb2 or trpv1, receptors. j physiol. 2011 may 1;589(pt 9):2415-31.

Ibipinabant Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 47)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8617 58
SLV319 ibipinabant (4S)-3-(4-Chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide (S)-SLV 319 BMS 646256 (4S)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide 1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-, (4S)- Ibipinabant Impurity 1 ((S)-SLV 319) Ibipinabant/SLV319/BMS-646256 464213-10-3 1