Ethyl N-(4-methylphenyl)sulfonylcarbamate
- CAS No.
- 5577-13-9
- Chemical Name:
- Ethyl N-(4-methylphenyl)sulfonylcarbamate
- Synonyms
- Tosylurethane;ethyl tosylcarbaMate;Gliclazide IMpurity C;Gliclazide EP Impurity C;Tosylcarbamic acid ethyl ester;Ethyl [(4-Methylphenyl)sulphonyl]ca;ethyl n-(4-methylphenyl)sulfonylcarbamate;Ethyl [(4-methylphenyl)sulfonyl]-carbamate;Ethyl [(4-methylphenyl)sulphonyl]carbamate;Ethyl N-(4-methylbenzenesulfonyl)carbamate
- CBNumber:
- CB7512137
- Molecular Formula:
- C10H13NO4S
- Molecular Weight:
- 243.28
- MDL Number:
- MFCD00797861
- MOL File:
- 5577-13-9.mol
- MSDS File:
- SDS
| Melting point | 82-84oC |
|---|---|
| Boiling point | 272℃ at 100.8-101kPa |
| Density | 1.38 at 20℃ |
| vapor pressure | 1.8-7.9Pa at 20-25℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| color | White |
| LogP | 0.73-1.7 at 23℃ and pH2-7 |
| Surface tension | 63.8mN/m at 1g/L and 20℃ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| REACH Registrations | Active |
Ethyl N-(4-methylphenyl)sulfonylcarbamate price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-T686900-1G | Tosylurethane | 5577-13-9 | 1g | $211 | 2026-06-03 | Buy |
| TRC | TRC-T686900-10G | Tosylurethane | 5577-13-9 | 10g | $1575 | 2026-06-03 | Buy |
| ChemScene | CS-0111672 | Ethyl tosylcarbamate ≥98% | 5577-13-9 | 500g | $1363 | 2026-06-04 | Buy |
| Synthonix | E52995 | Ethyl tosylcarbamate 95+% | 5577-13-9 | 100mg | $13 | 2026-05-06 | Buy |
| Synthonix | E52995 | Ethyl tosylcarbamate 95+% | 5577-13-9 | 250mg | $60 | 2026-05-06 | Buy |
Ethyl N-(4-methylphenyl)sulfonylcarbamate Chemical Properties, Uses, Production
Uses
Tosylurethane (Gliclazide EP Impurity C) is an intermediate in the synthesis of Gliclazide (G409877), a sulfonylurea hypoglycemic agent. Used as an antidiabetic.
Synthesis
64-17-5
![Carbamic acid, N-[(4-methylphenyl)sulfonyl]-, butyl ester](/CAS/20210305/GIF/31224-37-0.gif)
31224-37-0
5577-13-9
GENERAL STEPS: Dissolve 4-methylphenylsulfonylcarbamate (Compound, CAS:31224-37-0) in selected alcohol (ethanol, 2 mL) in a microwaveable reaction vial. The reaction vial was sealed using an aluminum cap with a PTFE-faced septum. The reaction mixture was placed in a microwave reactor and radiantly heated at 100-120°C for 20-60 min. Upon completion of the reaction, the crude product was concentrated under reduced pressure and the residue was subsequently purified by silica gel column chromatography to finally obtain the target product, ethyl N-(4-methylphenyl)sulfonylcarbamate.
References
[1] Tetrahedron Letters, 2016, vol. 57, # 13, p. 1476 - 1478
Ethyl N-(4-methylphenyl)sulfonylcarbamate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9334 | 55 |
| Cantotech Chemicals, Ltd. | 86-0755-86635001 | cantotech@126.com | China | 4554 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Beijing FYF Chemicals Co., Ltd | 010-57903446 15869909019 | 168931144@qq.com | China | 2912 | 58 |
