UNC-2170 maleate
- CAS No.
- 2173992-60-2
- Chemical Name:
- UNC-2170 maleate
- Synonyms
- 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-benzamide,2Z-butenedioate
- CBNumber:
- CB75867487
- Molecular Formula:
- C18H25BrN2O5
- Molecular Weight:
- 429.31
- MDL Number:
- MOL File:
- 2173992-60-2.mol
UNC-2170 maleate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17374 | UNC2170 (maleate) ≥95% | 2173992-60-2 | 1 mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 17374 | UNC2170 (maleate) ≥95% | 2173992-60-2 | 5 mg | $186 | 2024-03-01 | Buy |
| Cayman Chemical | 17374 | UNC2170 (maleate) ≥95% | 2173992-60-2 | 10 mg | $347 | 2024-03-01 | Buy |
| Cayman Chemical | 17374 | UNC2170 (maleate) ≥95% | 2173992-60-2 | 25 mg | $750 | 2024-03-01 | Buy |
UNC-2170 maleate Chemical Properties,Uses,Production
Description
p53-Binding protein 1 (53BP1) binds to dimethylated lysine 20 on histone 4 (H4K20me2) via tandem tudor domains on a 53BP1 homodimer.1 This interaction is an important part of the DNA damage response.1 UNC2170 is a micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains.2 It displays at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins.2 UNC2170 functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain.2
References
1. Botuyan, M.V., Lee, J., Ward, I.M., et al. Structural basis for the methylation state-
2. Perfetti, M.T., Baughman, B.M., Dickson, B.M., et al. Identification of a fragment-
UNC-2170 maleate Preparation Products And Raw materials
Raw materials
Preparation Products
UNC-2170 maleate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4996 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19699 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12000 | 58 |