Previridicatumtoxin
- CAS No.
- 1379585-81-5
- Chemical Name:
- Previridicatumtoxin
- Synonyms
- Previridicatumtoxin;(4aS,5S,12aS)-6-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-1,4,4a,5,12,12a-hexahydro-3,4a,5,10,11,12a-hexahydroxy-8-methoxy-1,12-dioxo-2-naphthacenecarboxamide
- CBNumber:
- CB76197761
- Molecular Formula:
- C30H33NO10
- Molecular Weight:
- 567.59
- MDL Number:
- MOL File:
- 1379585-81-5.mol
Previridicatumtoxin Chemical Properties,Uses,Production
Biological Activity
Previridicatumtoxin is a fungal metabolite that has been found in P. aethiopicum and has diverse biological activities.1,2 It is an intermediate in the biosynthesis of the mycotoxin viridicatumtoxin . Previridicatumtoxin is active against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis (IC50s = 4.4 and 4.8 μM, respectively), as well as C. albicans and S. cerevisiae (MIC = 32 μg/ml for both).2,1 It is cytotoxic to NCI H460, KB-3-1, and SW620 cancer cells (IC50s = 5.3, 4.1, and 6 μM, respectively).2
References
1.Chooi, Y.H., Wang, P., Fang, J., et al.Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferasesJ. Am. Chem. Soc.134(22)9428-9437(2012) 2.Shang, Z., Salim, A.A., Khalil, Z., et al.Viridicatumtoxins: Expanding on a rare tetracycline antibiotic scaffoldJ. Org. Chem.80(24)12501-12508(2015)
Previridicatumtoxin Preparation Products And Raw materials
Raw materials
Preparation Products
Previridicatumtoxin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Supplier | Advantage |
|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |