ChemicalBook >> CAS DataBase List >>JKE-1716
JKE-1716
- CAS No.
- 2421118-05-8
- Chemical Name:
- JKE-1716
- Synonyms
- JKE-1716;JKE 1716,JKE1716;3-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-1-nitro-1,3-propanedione, 1-oxime;1,3-Propanedione, 3-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-1-nitro-, 1-oxime
- CBNumber:
- CB76197998
- Molecular Formula:
- C20H20Cl2N4O4
- Molecular Weight:
- 451.3
- MDL Number:
- MFCD34474031
- MOL File:
- 2421118-05-8.mol
Last updated:2024-07-02 08:55:17
JKE-1716 Chemical Properties,Uses,Production
Biological Activity
JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1 JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .
References
1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)
JKE-1716 Preparation Products And Raw materials
Raw materials
Preparation Products
JKE-1716 Suppliers
Global( 5)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| ChemeGen 中国 | 58 |
| TargetMol Chemicals Inc. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
JKE-1716
JKE 1716,JKE1716
1,3-Propanedione, 3-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-1-nitro-, 1-oxime
3-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-1-nitro-1,3-propanedione, 1-oxime
2421118-05-8