EA4
- CAS No.
- 389614-94-2
- Chemical Name:
- EA4
- Synonyms
- EA4;7-chloro-6-[4-(diethylamino)phenyl]quinoline-5,8-dione;5,8-Quinolinedione, 7-chloro-6-[4-(diethylamino)phenyl]-
- CBNumber:
- CB7697201
- Molecular Formula:
- C19H17ClN2O2
- Molecular Weight:
- 340.8
- MDL Number:
- MFCD08457916
- MOL File:
- 389614-94-2.mol
- MSDS File:
- SDS
EA4 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CB_96073116 | Ea.4 96073116 | 96073116-DNA-5UG | $390 | 2024-03-01 | Buy | |
| Sigma-Aldrich | CB_96073116 | Ea.4 96073116 | 1VIAL | $951 | 2024-03-01 | Buy | |
| Cayman Chemical | 10111 | EA4 ≥95% | 389614-94-2 | 5mg | $90 | 2024-03-01 | Buy |
| Cayman Chemical | 10111 | EA4 ≥95% | 389614-94-2 | 10mg | $171 | 2024-03-01 | Buy |
| Cayman Chemical | 10111 | EA4 ≥95% | 389614-94-2 | 50mg | $710 | 2024-03-01 | Buy |
EA4 Chemical Properties,Uses,Production
Biological Activity
ki: 130 μmea4 is a rpla2 inhibitor.rpla2, a calcium-dependent cytosolic phospholipase a2 (cpla2), was initially isolated and characterized from bovine and human red blood cells. with a molecular mass of 42 kda, cpla2 shows biochemical properties similar to cpla2 type iv.
in vitro
it was found that ea4 was able to inhibit a ca(2+) ionophore-induced arachidonic acid release from both human and bovine red blood cells, demonstrating that this enzyme was responsible for the ca(2+)-dependent arachidonic acid release from mammalian red blood cells [1]. another study found that in mouse hepatoma hepa-1c1c7 cells, ea4 could cause a significant induction of the cyp1a1-mediated ethoxyresorufin o-deethylase activity time- and concentration-dependently, and such induction was accompanied by an increase of the cyp1a1 mrna transcription. morevoer, in human cells including mcf-7 (human breast adenocarcinoma cell line), hepg2 (human hepatocarcinoma), and hl-60 (human promyelocytic cell line), the expression of cyp1a1 mrna could be also induced by ea4 treatment. in addition, cyp1b1 mrna was increased by ea4 in mcf-7 cells [2].
References
1. shin, h.s.,chin, m.r.,kim, j.s., et al. purification and characterization of a cytosolic, 42-kda and ca2+-dependent phospholipase a2 from bovine red blood cells. the journal of biological chemisty 277, 21086-21094 (2002).2. chun, y.j.,lee, b.y.,yang, s.a., et al. induction of cytochrome p450 1a1 gene expression by a vitamin k3 analog in mouse hepatoma hepa-1c1c7 cells. molecules and cells 12, 190-196 (2001).
EA4 Preparation Products And Raw materials
Raw materials
Preparation Products
EA4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6753 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 6813 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9266 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6251 | 58 |