tert-Butyl chloroacetate
- CAS No.
- 107-59-5
- Chemical Name:
- tert-Butyl chloroacetate
- Synonyms
- 153N-6;NSC 87891;ClCH2C(O)OC(CH3)3;(10E)-3-O-De(αtert-Butyl chloroace;T-BUTYL CHLOROACETATE;TERT-BUTYL CHLORACETATE;3-Formyl Tyrosol αreft-Butyl chloroacetate;TERT-BUTYL CHLOROACETATE
- CBNumber:
- CB7749461
- Molecular Formula:
- C6H11ClO2
- Molecular Weight:
- 150.6
- MDL Number:
- MFCD00000930
- MOL File:
- 107-59-5.mol
- MSDS File:
- SDS
Boiling point | 48-49 °C/11 mmHg (lit.) |
---|---|
Density | 1.053 g/mL at 25 °C (lit.) |
refractive index |
n |
Flash point | 116 °F |
storage temp. | Flammables area |
form | Liquid |
color | Clear colorless to yellow |
Specific Gravity | 1.053 |
Water Solubility | <0.1 g/L (20 ºC) |
Merck | 14,1563 |
BRN | 1753006 |
LogP | 2.07 |
CAS DataBase Reference | 107-59-5(CAS DataBase Reference) |
FDA UNII | 05TMW98298 |
NIST Chemistry Reference | Acetic acid, chloro-, 1,1-dimethylethyl ester(107-59-5) |
EPA Substance Registry System | Acetic acid, chloro-, 1,1-dimethylethyl ester (107-59-5) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS02,GHS05,GHS06,GHS09 |
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Signal word | Danger | |||||||||
Hazard statements | H302+H312+H332-H315-H319-H302-H312-H335-H400-H410-H226-H302+H312-H314-H331 | |||||||||
Precautionary statements | P273-P280h-P309-P501a-P261-P280-P305+P351+P338-P310-P210-P233-P240-P241+P242+P243-P264-P270-P271-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P370+P378-P403+P235-P501 | |||||||||
Hazard Codes | C,N,Xn,Xi,F | |||||||||
Risk Statements | 20/21/22-34-50/53-36/37/38-10 | |||||||||
Safety Statements | 26-36/37/39-45-61-60-16-7/9 | |||||||||
RIDADR | UN 2920 8/PG 2 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | AF8985500 | |||||||||
F | 19-21 | |||||||||
TSCA | Yes | |||||||||
HazardClass | 3 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29154000 | |||||||||
Toxicity | rat,LC50,inhalation,4738mg/m3/4H (4738mg/m3),SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTIONLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: TREMOR,International Journal of Toxicology. Vol. 19, Pg. 333, 2000. | |||||||||
NFPA 704 |
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tert-Butyl chloroacetate price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 186791 | tert-Butyl chloroacetate 97% | 107-59-5 | 25g | $46.8 | 2024-03-01 | Buy |
Sigma-Aldrich | 186791 | tert-Butyl chloroacetate 97% | 107-59-5 | 100g | $83.2 | 2024-03-01 | Buy |
TCI Chemical | C1267 | tert-Butyl Chloroacetate >97.0%(GC) | 107-59-5 | 25mL | $33 | 2024-03-01 | Buy |
TCI Chemical | C1267 | tert-Butyl Chloroacetate >97.0%(GC) | 107-59-5 | 500mL | $94 | 2024-03-01 | Buy |
Alfa Aesar | A15833 | tert-Butyl chloroacetate, 98% | 107-59-5 | 25g | $26.65 | 2024-03-01 | Buy |
tert-Butyl chloroacetate Chemical Properties,Uses,Production
Chemical Properties
clear colorless to yellow liquid. Hydrolysis generates tert-butanol and chloroacetic acid.
Uses
tert-Butyl chloroacetate is used in the synthesis of imidazol-1-yl-acetic acid hydrochloride, cis-disubstituted aziridine ester via aza-Darzens reaction and 1,10-diaza-18-crown-6 based sensors bearing a coumarin fluorophore.
Uses
In the glycidic ester condensation.
Preparation
tert-Butyl chloroacetate synthesis: The tert-butanol was added to the mixture of chloroacetyl chloride and N,N-dimethylaniline, and the temperature was kept below 30°C. The reactant was poured into water, washed and dried, and then fractionated under reduced pressure. The fractions at 48-49°C (1.46kPa) were collected to obtain tert-butyl chloroacetate with a yield of 63%.
Safety Profile
A poison by ingestion. Moderately toxic by inhalation skin contact. S severe sluin and moderate eye irritant. When heated to decomposition it emits toxic vapors of Cl-.
Purification Methods
Check the NMR spectrum; if satisfactory then distil in a vacuum; if not then dissolve in Et2O, wash with H2O, 10% H2SO4 until the acid extract does not become cloudy when made alkaline with NaOH. Wash the organic layer again with H2O, then saturated aqueous NaHCO3, dry over Na2SO4, evaporate and fractionate it through a carborundum-packed column or a 6-inch Widmer column (p 11, see tert-butyl ethyl malonate for precautions to avoid decomposition during disillation). [Johnson et al. J Am Chem Soc 75 4995 1953, Baker Org Synth Coll Vol III 144 1944, Beilstein 2 III 444.]
tert-Butyl chloroacetate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Jiangxi Sunway Chemical Co., Ltd. | +86-0794-5259909 +8615888611133 | dave@jxswchem.com | China | 22 | 58 |
Jiangxi Sunway Chemical Co., Ltd. | +86-0794-5259909 +8615888611133 | dave@jxswchem.com | China | 22 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12495 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5895 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21663 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Kingfirst chemical (nanjing) co.,ltd | 86-25-84522992 | marketing@kingfirstchem.com | CHINA | 95 | 58 |
View Lastest Price from tert-Butyl chloroacetate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-30 | tert-Butyl chloroacetate
107-59-5
|
US $0.00 / KG | 1KG | 99% | 1000mt/year | Jinan Finer Chemical Co., Ltd | ||
2024-09-29 | Tert-Butyl Chloroacetate
107-59-5
|
US $19.00-19.00 / KG | 1KG | 99.% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | ||
2024-08-15 | tert-Butyl chloroacetate
107-59-5
|
US $0.00 / kg | 1kg | 0.985 | 20tons | Hebei Yanxi Chemical Co., Ltd. |
- tert-Butyl chloroacetate
107-59-5
- US $0.00 / KG
- 99%
- Jinan Finer Chemical Co., Ltd
- Tert-Butyl Chloroacetate
107-59-5
- US $19.00-19.00 / KG
- 99.%
- Hebei Chuanghai Biotechnology Co,.LTD
- tert-Butyl chloroacetate
107-59-5
- US $0.00 / kg
- 0.985
- Hebei Yanxi Chemical Co., Ltd.